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The flow convergence method includes calculation of the proximal isovelocity surface area (PISA) and is widely used to classify mitral regurgitation (MR) with echocardiography. It constitutes a primary decision factor for determination of…

We measure different contributions to entropy production in a living functional epithelial tissue. We do this by extracting the functional dynamics of development while at the same time quantifying fluctuations. Using the translucent…

Soft Condensed Matter · Physics 2023-01-25 Mark Olenik , Jake Turley , Stephen Cross , Helen Weavers , Paul Martin , Isaac Chenchiah , Tanniemola Liverpool

Coding information is the main source of heterogeneity (non-randomness) in the sequences of bacterial genomes. This information can be naturally modeled by analysing cluster structures in the "in-phase" triplet distributions of relatively…

Genomics · Quantitative Biology 2011-11-09 A. N. Gorban , T. G. Popova , A. Yu. Zinovyev

Microrheology, the study of fluids on micron length-scales, promises to reveal insights into cellular biology, including mechanical biomarkers of disease and the interplay between biomechanics and cellular function. Here a…

Microorganisms are ubiquitous in nature and technology. They inhabit diverse environments ranging from small river tributaries and lakes to oceans, as well as wastewater treatment plants and food manufacturing. In many of these…

A systematic study is carried out on a fully resolved fluid-particle model which couples the Lattice Boltzmann Method (LBM) and the Discrete Element Method (DEM) using an immersed moving boundary technique. Similar algorithms have been…

Computational Physics · Physics 2019-06-21 G. C. Yang , L. Jing , C. Y. Kwok , Y. D. Sobral

Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions. While the topological…

Molecular Networks · Quantitative Biology 2015-06-26 E. Almaas , B. Kovacs , T. Vicsek , Z. N. Oltvai , A. -L. Barabasi

A comparative study on mesh-based and mesh-less Computational Fluid Dynamics (CFD) approaches coupled with the Discrete Element Method (DEM) is presented. As the mesh-based CFD approach a Finite Volume Method (FVM) is used. A Smoothed…

Fluid Dynamics · Physics 2016-09-28 D. Markauskas , H. Kruggel-Emden , R. Sivanesapillai , H. Steeb

Bacterial suspensions--a premier example of active fluids--show an unusual response to shear stresses. Instead of increasing the viscosity of the suspending fluid, the emergent collective motions of swimming bacteria can turn a suspension…

Soft Condensed Matter · Physics 2018-09-05 Shuo Guo , Devranjan Samanta , Yi Peng , Xinliang Xu , Xiang Cheng

In the present work we simulate the basic two-dimensional dynamics of swarming E. coli bacteria on the surface of a moderately soft agar plate. Individual bacteria are modelled by self-propelled ridged bodies (agents), which interact with…

Soft Condensed Matter · Physics 2016-12-31 David Hansmann , Guido Fier , Rubén Carlos Buceta

Small - but finite - fluid inertia can be leveraged to generate steady flows out of liquid vibrations around an immersed interface. In engineering, external high-frequency drivers (10$^2$-10$^5$ Hz) allow this inertial rectification…

Non-particulate continuum descriptions allow for computationally efficient modeling of suspension flows at scales that are inaccessible to more detailed particulate approaches. It is well known that the presence of particles influences the…

Soft Condensed Matter · Physics 2013-11-13 Florian Janoschek , Jens Harting , Federico Toschi

We study the mechanics of evaporation and precipitate formation in pure and bacteria-laden sessile whole blood droplets in the context of disease diagnostics. Using experimental and theoretical analysis, we show evaporation process has…

High-resolution and anatomically realistic computer models of biological soft tissues play a significant role in the understanding of the function of cardiovascular components in health and disease. However, the computational effort to…

Medical Physics · Physics 2015-08-12 Christoph M. Augustin , Gerhard A. Holzapfel , Olaf Steinbach

The mechanism of bacterial cell size control has been a mystery for decades, which involves the well-coordinated growth and division in the cell cycle. The revolutionary modern techniques of microfluidics and the advanced live imaging…

Statistical Mechanics · Physics 2021-08-30 Liang Luo , Yang Bai , Xiongfei Fu

Accelerating imaging speed in optical microscopy is often realized at the expense of image contrast, image resolution, and detection sensitivity- a common predicament for advancing high-speed and high-throughput cellular imaging. We here…

Analysing the haemodynamics of flow in carotid artery disease serves as a means to better understand the development and progression of associated complex diseases. Carotid artery disease can predispose people to major adverse…

Bacteria living on surfaces are often confined to droplets. When these droplets evaporate, the motion of the liquid-air interface and the associated internal capillary flow confine the bacteria. Here we study how \emph{E. coli} bacteria…

Objective: Exploit accelerometry data for an automatic, reliable, and prompt detection of spontaneous circulation during cardiac arrest, as this is both vital for patient survival and practically challenging. Methods: We developed a machine…

Signal Processing · Electrical Eng. & Systems 2023-02-13 Wolfgang J. Kern , Simon Orlob , Andreas Bohn , Wolfgang Toller , Jan Wnent , Jan-Thorsten Gräsner , Martin Holler

An upgrade to the ATLAS silicon tracker cooling control system may require a change from C3F8 (octafluoro-propane) to a blend containing 10-30% of C2F6 (hexafluoro-ethane) to reduce the evaporation temperature and better protect the silicon…

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