Four basic symmetry types in the universal 7-cluster structure of 143 complete bacterial genomic sequences
Abstract
Coding information is the main source of heterogeneity (non-randomness) in the sequences of bacterial genomes. This information can be naturally modeled by analysing cluster structures in the "in-phase" triplet distributions of relatively short genomic fragments (200-400bp). We found a universal 7-cluster structure in bacterial genomic sequences and explained its properties. We show that codon usage of bacterial genomes is a multi-linear function of their genomic G+C-content with high accuracy. Based on the analysis of 143 completely sequenced bacterial genomes available in Genbank in August 2004, we show that there are four "pure" types of the 7-cluster structure observed. All 143 cluster animated 3D-scatters are collected in a database and is made available on our web-site: http://www.ihes.fr/~zinovyev/7clusters The finding can be readily introduced into any software for gene prediction, sequence alignment or bacterial genomes classification.
Keywords
Cite
@article{arxiv.q-bio/0410033,
title = {Four basic symmetry types in the universal 7-cluster structure of 143 complete bacterial genomic sequences},
author = {A. N. Gorban and T. G. Popova and A. Yu. Zinovyev},
journal= {arXiv preprint arXiv:q-bio/0410033},
year = {2011}
}
Comments
13 pages, 4 figures