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Simulation is a powerful tool for exploring uncertainty. Its potential in clinical medicine is transformative and includes personalized treatment planning and virtual clinical trials. However, simulating patient trajectories is challenging…

Artificial Intelligence · Computer Science 2026-01-27 Yu Akagi , Tomohisa Seki , Hiromasa Ito , Toru Takiguchi , Kazuhiko Ohe , Yoshimasa Kawazoe

Objective: To transform heterogeneous clinical data from electronic health records into clinically meaningful constructed features using data driven method that rely, in part, on temporal relations among data. Materials and Methods: The…

Machine Learning · Computer Science 2017-06-22 Edward Choi , Andy Schuetz , Walter F. Stewart , Jimeng Sun

Due to the limited accuracy of 4D Magnetic Resonance Imaging (MRI) in identifying hemodynamics in cardiovascular diseases, the challenges in obtaining patient-specific flow boundary conditions, and the computationally demanding and…

Machine Learning · Computer Science 2025-03-25 Oscar L. Cruz-González , Valérie Deplano , Badih Ghattas

In recent years, human in silico trials have gained significant traction as a powerful approach to evaluate the effects of drugs, clinical interventions, and medical devices. In silico trials not only minimise patient risks but also reduce…

Computational Engineering, Finance, and Science · Computer Science 2025-03-06 Ruben Doste , Julia Camps , Zhinuo Jenny Wang , Lucas Arantes Berg , Maxx Holmes , Hannah Smith , Marcel Beetz , Lei Li , Abhirup Banerjee , Vicente Grau , Blanca Rodriguez

Agent-based simulation (ABS) models are potent tools for analyzing complex systems. However, understanding and validating ABS models can be a significant challenge. To address this challenge, cutting-edge data-driven techniques offer…

Multiagent Systems · Computer Science 2025-07-11 Rob H. Bemthuis , Ruben R. Govers , Amin Asadi

Background: Most acute stroke (AS) patients in the United States are initially evaluated at a primary stroke center (PSC) and a significant proportion requires transfer to a comprehensive stroke center (CSC) for advanced treatment. A CSC…

Quantitative Methods · Quantitative Biology 2022-02-16 Hojun Choi , Ohad Perry , Jane Holl , Shyam Prabhakaran

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and…

Quantitative Methods · Quantitative Biology 2024-04-25 Alan D. Kaplan , Priyadip Ray , John D. Greene , Vincent X. Liu

The optimisation in the ambulance dispatching process is significant for patients who need early treatments. However, the problem of dynamic ambulance redeployment for destination hospital selection has rarely been investigated. The paper…

Computers and Society · Computer Science 2022-01-07 Xinyu Fu , Valeria Krzhizhanovskaya , Alexey Yakovlev , Sergey Kovalchuk

Patient safety training is essential for preparing healthcare professionals to identify, investigate, and prevent adverse events. However, conventional simulation-based approaches often require substantial faculty time, physical resources,…

Human-Computer Interaction · Computer Science 2026-03-20 Yuqi Hu , Qiwen Xiong , Zhenzhen Qin , Brandon Watanabe , Yujing Wang , Mirjana Prpa , Ilmi Yoon

Electronic health records (EHR) systematically represent patient data in digital form. However, text and visualization based EHR systems are poorly integrated in the hospital workflow due to their complex and rather non-intuitive access…

Human-Computer Interaction · Computer Science 2020-02-28 Dmitri Presnov , Julia Kurz , Judith Willkomm , Daniel Alt , Johannes Dillmann , Robert Zilke , Veit Braun , Cornelius Schubert , Andreas Kolb

In this paper, we review data mining approaches for health applications. Our focus is on hardware-centric approaches. Modern computers consist of multiple processors, each equipped with multiple cores, each with a set of arithmetic/logical…

Machine Learning · Computer Science 2021-04-20 Marta Li Wang

Predicting (1) when the next hospital admission occurs and (2) what will happen in the next admission about a patient by mining electronic health record (EHR) data can provide granular readmission predictions to assist clinical decision…

Machine Learning · Computer Science 2021-02-05 Bhagya Hettige , Weiqing Wang , Yuan-Fang Li , Suong Le , Wray Buntine

Simulations of coronary hemodynamics have improved non-invasive clinical risk stratification and treatment outcomes for coronary artery disease, compared to relying on anatomical imaging alone. However, simulations typically use empirical…

This study reports the findings of qualitative interview sessions conducted with ICU clinicians for the co-design of a system user interface of an artificial intelligence (AI)-driven clinical decision support (CDS) system. This system…

Human-Computer Interaction · Computer Science 2025-03-13 Andrea E. Davidson , Jessica M. Ray , Ayush K. Patel , Yulia Strekalova Levites , Parisa Rashidi , Azra Bihorac

The advent of foundation models (FMs) as an emerging suite of AI techniques has struck a wave of opportunities in computational healthcare. The interactive nature of these models, guided by pre-training data and human instructions, has…

Machine Learning · Computer Science 2026-04-30 Yunkun Zhang , Jin Gao , Zheling Tan , Lingfeng Zhou , Kexin Ding , Mu Zhou , Shaoting Zhang , Dequan Wang

Innovation in healthcare payment and service delivery utilizes high cost, high risk pilots paired with traditional program evaluations. Decision-makers are unable to reliably forecast the impacts of pilot interventions in this complex…

Three-dimensional cardiovascular fluid dynamics simulations typically require computation of several cardiac cycles before they reach a periodic solution, rendering them computationally expensive. Furthermore, there is currently no…

Computational Engineering, Finance, and Science · Computer Science 2021-06-28 Martin R. Pfaller , Jonathan Pham , Nathan M. Wilson , David W. Parker , Alison L. Marsden

Healthcare professionals have long envisioned using the enormous processing powers of computers to discover new facts and medical knowledge locked inside electronic health records. These vast medical archives contain time-resolved…

Machine Learning · Computer Science 2020-05-15 Ahmed Allam , Matthias Dittberner , Anna Sintsova , Dominique Brodbeck , Michael Krauthammer

COVID-19 has caused an enormous burden on healthcare facilities around the world. Cohorting patients and healthcare professionals (HCPs) into "bubbles" has been proposed as an infection-control mechanism. In this paper, we present a novel…

Social and Information Networks · Computer Science 2021-05-14 D. M. Hasibul Hasan , Alex Rohwer , Hankyu Jang , Ted Herman , Philip M. Polgreen , Daniel K. Sewell , Bijaya Adhikari , Sriram V. Pemmaraju

Objective: When patients develop acute respiratory failure, accurately identifying the underlying etiology is essential for determining the best treatment. However, differentiating between common medical diagnoses can be challenging in…

Machine Learning · Computer Science 2022-04-21 Sarah Jabbour , David Fouhey , Ella Kazerooni , Jenna Wiens , Michael W Sjoding