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This study presents a novel and user-friendly technique for detecting the lateral capillary force on a floating spherical particle. The technique leverages the interplay between the capillary attracting forces, hydrostatic pressure forces,…

Fluid Dynamics · Physics 2023-07-12 David Shulman

Traction Force Microscopy (TFM) computes the forces exerted at the surface of an elastic material by measuring induced deformations in volume. It is used to determine the pattern of the adhesion forces exerted by cells or by cellular…

Biological Physics · Physics 2018-02-09 Stanislav Makarchuk , Nicolas Beyer , Christian Gaiddon , Wilfried Grange , Pascal Hébraud

Various methods of force measurement with the Atomic Force Microscope (AFM) are compared for their ability to accurately determine the tip-surface force from analysis of the nonlinear cantilever motion. It is explained how intermodulation,…

Mesoscale and Nanoscale Physics · Physics 2013-03-12 Daniel Platz , Daniel Forchheimer , Erik A. Tholén , David B. Haviland

A force measurement technique has been developed that utilizes a clamped fiber optic element both as a cantilever and as a highly sensitive probe of the static and dynamic displacement of a sample that is mounted near its free end. Light…

Condensed Matter · Physics 2009-11-07 R. Budakian , S. J. Putterman

Using Coarse-Grained Molecular Dynamics simulations, we study the relaxation of bilayer vesicles, uniaxially compressed by an Atomic Force Microscope (AFM) cantilever. The relaxation time exhibits a strong force-dependence.…

Soft Condensed Matter · Physics 2016-12-21 Ben M. Barlow , Martine Bertrand , Béla Joos

We report an improved precision measurement of the Casimir force. The force is measured between a large Al coated sphere and flat plate using an Atomic Force Microscope. The primary experimental improvements include the use of smoother…

Quantum Physics · Physics 2009-07-09 Anushree Roy , Chiung-Yuan Lin , U. Mohideen

We present a simple method for accessing the elastic properties of microscopic deformable particles. This method is based on measuring the pressure-induced deformation of soft particles as they are forced through a tapered glass…

Soft Condensed Matter · Physics 2012-09-04 Hans M. Wyss , Thomas Franke , Elisa Mele , David A. Weitz

We report an Atomic Force Microscopy (AFM) study on thick multi lamellar stacks of approx. 10 mum thickness (about 1500 stacked membranes) of DMPC (1,2-dimyristoyl-sn-glycero-3-phoshatidylcholine) deposited on silicon wafers. These thick…

Biological Physics · Physics 2009-10-02 Arne Schafer , Tim Salditt , Maikel C. Rheinstadter

Quantifying the tip-sample interaction at the nanoscale in Amplitude Modulation mode AFM is challenging, especially when measuring in liquids. Here, we derive formulas for the tip-sample conservative and dissipative interactions and…

Instrumentation and Detectors · Physics 2015-11-24 Luca Costa , Mario S Rodrigues

The functionalization of an Atomic Force Microscope (AFM) cantilever with a colloidal bead is a widely used technique when the geometry between the probe and the sample must be controlled, particularly in force spectroscopy. But some…

Mesoscale and Nanoscale Physics · Physics 2013-05-09 Justine Laurent , Audrey Steinberger , Ludovic Bellon

Amplitude-modulation atomic force microscopy (AM-AFM) measures nanoscale surface structures by detecting changes in the cantilever oscillation amplitude, contributing to materials research. AM-AFM can non-destructively observe fragile…

Applied Physics · Physics 2025-06-18 Kenichi Umeda , Karen Kamoshita , Noriyuki Kodera

Mechanical properties of biological samples have been imaged with a \textit{Force Feedback Microscope}. Force, force gradient and dissipation are measured simultaneously and quantitatively, merely knowing the AFM cantilever spring constant.…

Biological Physics · Physics 2014-05-01 Luca Costa , Mario S Rodrigues , Emily Newman , Chloe Zubieta , Joel Chevrier , Fabio Comin

Atomic force microscopy (AFM) is a mechanical profiling technique that allows to image surfaces with atomic resolution. Recent progress in reducing the noise of this technique has led to a resolution level where previously undetectable…

Materials Science · Physics 2015-06-24 F. J. Giessibl , H. Bielefeldt , S. Hembacher , J. Mannhart

Atomically-resolved imaging and force measurements using the atomic force microscope (AFM) are performed most commonly in a frequency-modulation (FM) mode. This has led to spectacular results, including direct observation of the atomic…

Mesoscale and Nanoscale Physics · Physics 2018-12-26 John E. Sader , Barry D. Hughes , Ferdinand Huber , Franz J. Giessibl

Colloidal probes are often used in force microscopy when the geometry of the tip-sample interaction should be well controlled. Their calibration requires the understanding of their mechanical response, which is very sensitive to the details…

Instrumentation and Detectors · Physics 2024-03-08 Aubin Archambault , Caroline Crauste-Thibierge , Ludovic Bellon

Atomic force microscopy (AFM) is an analytical surface characterization tool which can reveal a sample's topography with high spatial resolution while simultaneously probing tip-sample interactions. Local measurement of chemical properties…

Applied Physics · Physics 2018-09-06 Omur E. Dagdeviren , Yoichi Miyahara , Aaron Mascaro , Peter Grutter

The local work function of a surface determines the spatial decay of the charge density at the Fermi level normal to the surface. Here, we present a method that enables simultaneous measurements of local work function and tip-sample forces.…

Materials Science · Physics 2007-05-23 M. Herz , Ch. Schiller , F. J. Giessibl , J. Mannhart

Numerous cell types relate to their immediate environment by exerting a three-dimensional pressure field on their environment, with components both longitudinal and transverse to the cell membrane. This pressure field can in principle be…

Soft Condensed Matter · Physics 2026-03-09 Quentin Bédel , Loïc Dupré , Nicolas Destainville

Molecular dynamics simulations are used to study the capillary adhesion from a nonvolatile liquid meniscus between a spherical tip and a flat substrate. The atomic structure of the tip, the tip radius, the contact angles of the liquid on…

Soft Condensed Matter · Physics 2014-06-10 Shengfeng Cheng , Mark O. Robbins

Two cylinders rotating next to each other generate a large hydrodynamic force if the intermediate space is filled with a viscous fluid. Herein, we explore the case where the cylinders are separated by two layers of viscous immiscible…

Soft Condensed Matter · Physics 2024-03-29 Aditya Jha , Yacine Amarouchene , Thomas Salez