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Absolute quantity imaging of biomolecules on a single cell level is critical for measurement assurance in biosciences and bioindustries. While infrared (IR) transmission microscopy is a powerful label-free imaging modality capable of…

Quantitative Methods · Quantitative Biology 2024-03-29 Yow-Ren Chang , Seong-Min Kim , Young Jong Lee

A to-date unsolved and highly limiting safety concern for Ultra High-Field (UHF) magnetic resonance imaging (MRI) is the deposition of radiofrequency (RF) power in the body, quantified by the specific absorption rate (SAR), leading to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-02 Simone Angela Winkler , Isabelle Saniour , Akshay Chaudhari , Fraser Robb , J Thomas Vaughan

The CHIME radio telescope operates in the frequency bandwidth of 400 to 800 MHz. The CHIME/FRB collaboration has a data pipeline that analyzes the data in real time, suppresses radio frequency interferences (RFI) and searches for FRBs.…

Instrumentation and Methods for Astrophysics · Physics 2023-11-21 K. J. Luke

Quantitative phase imaging (QPI) quantifies the sample-specific optical-phase-delay enabling objective studies of optically-transparent specimens such as biological samples, but lacks chemical sensitivity limiting its application to…

Optics · Physics 2019-09-04 Miu Tamamitsu , Keiichiro Toda , Ryoichi Horisaki , Takuro Ideguchi

The development of photonic integrated circuits would benefit from a wider selection of materials that can strongly-control near-infrared (NIR) light. Transition metal dichalcogenides (TMDs) have been explored extensively for visible…

Mesoscale and Nanoscale Physics · Physics 2019-10-18 Akshay Singh , Yifei Li , Balint Fodor , Laszlo Makai , Jian Zhou , Haowei Xu , Austin Akey , Ju Li , R. Jaramillo

The evaluation and monitoring of cells health in the human retina is crucial and follow time course of retinal diseases, detect lesions before irreversible visual loss and to evaluate treatment effects. Towards this goal, a major challenge…

By patterning a freestanding dielectric membrane into a photonic crystal reflector (PCR), it is possible to resonantly enhance its normal-incidence reflectivity, thereby realizing a thin, single-material mirror. In many PCR applications,…

FRET measurements can provide dynamic spatial information on length scales smaller than the diffraction limit of light. Several methods exist to measure FRET between fluorophores, including Fluorescence Lifetime Imaging Microscopy (FLIM),…

Quantitative Methods · Quantitative Biology 2017-01-09 Bryan Kaye , Peter J. Foster , Tae Yeon Yoo , Daniel J. Needleman

Magnetic resonance imaging (MRI) is the method of choice for noninvasive studies of micrometer-scale structures in biological tissues via their effects on the time/frequency-dependent ("restricted") and anisotropic self-diffusion of water.…

Soft Condensed Matter · Physics 2021-11-16 Omar Narvaez , Maxime Yon , Hong Jiang , Diana Bernin , Eva Forssell-Aronsson , Alejandra Sierra , Daniel Topgaard

Due to its specificity, fluorescence microscopy (FM) has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit FM's utility. Recently, it has been shown that…

We report the observation of imaging beyond the diffraction limit due to bound surface states in negative refraction photonic crystals. We achieve an effective negative index figure-of-merit [-Re(n)/Im(n)] of at least 380, ~125x improvement…

We realize a scanning probe microscope using single trapped $^{87}$Rb atoms to measure optical fields with subwavelength spatial resolution. Our microscope operates by detecting fluorescence from a single atom driven by near-resonant light…

Atomic Physics · Physics 2022-03-02 Emma Deist , Justin A. Gerber , Yue-Hui Lu , Johannes Zeiher , Dan M. Stamper-Kurn

Experimental validation is presented for a new type of microwave diagnostic, first introduced in the theoretical study in M. Usoltceva et al., Rev. Sci. Instrum. 93, 013502 (2022). A new term is adopted for this technique to highlight its…

Long baseline interferometry of microlensing events can resolve the individual images of the source produced by the lens, which combined with the modelling of the microlensing light curve, leads to the exact lens mass and distance.…

Earth and Planetary Astrophysics · Physics 2023-08-23 A. Cassan

Neural Radiance Fields (NeRFs) typically struggle to reconstruct and render highly specular objects, whose appearance varies quickly with changes in viewpoint. Recent works have improved NeRF's ability to render detailed specular appearance…

Computer Vision and Pattern Recognition · Computer Science 2024-05-24 Dor Verbin , Pratul P. Srinivasan , Peter Hedman , Ben Mildenhall , Benjamin Attal , Richard Szeliski , Jonathan T. Barron

Infrared (IR) nanospectroscopy by photothermal induced resonance (PTIR) is a novel experimental technique that combines the nanoscale resolution granted by atomic force microscopy (AFM) and the chemical labelling made possible by IR…

The InfraRed Imaging Spectrograph (IRIS) is a first-light instrument for the Thirty Meter Telescope (TMT). It combines a diffraction limited imager and an integral field spectrograph. This paper focuses on the electrical system of IRIS.…

Instrumentation and Methods for Astrophysics · Physics 2018-08-24 A. C. Trapp , James Larkin , Ken Magnone , Timothee Greffe , Tim Hardy , Jennifer Dunn , Eric Chisholm , Chris Johnson , Ryuji Suzuki

Over the last decade, single-molecule optical microscopy has become the gold-standard approach to decipher complex molecular processes in cellular environments. [1-3] Single-molecule fluorescence microscopy has several advantages such as…

Biological Physics · Physics 2017-11-15 Edakkattuparambil Sidharth Shibu , Nadezda Varkentina , Laurent Cognet , Brahim Lounis

Three-dimensional (3D) imaging of the subcellular organisation and morphology of cells and tissues is essential for understanding biological function. Although staining is the most widely used approach for visualising biological samples…

Photonic-chip based TIRF illumination has been used to demonstrate several on-chip optical nanoscopy methods. The sample is illuminated by the evanescent field generated by the electromagnetic wave modes guided inside the optical waveguide.…

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