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We study the existence of weak solutions to a Cahn--Hilliard--Darcy system coupled with a convection-reaction-diffusion equation through the fluxes, through the source terms and in Darcy's law. The system of equations arises from a mixture…

Analysis of PDEs · Mathematics 2016-10-25 Harald Garcke , Kei Fong Lam

We consider a diffuse interface model for tumour growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the…

Analysis of PDEs · Mathematics 2016-05-26 Harald Garcke , Kei Fong Lam

In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…

Analysis of PDEs · Mathematics 2018-11-19 Matthias Ebenbeck , Harald Garcke

We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The…

Analysis of PDEs · Mathematics 2023-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We study an evolutionary system of Cahn-Hilliard-Darcy type including mass source and transport effects. The system may arise in a number of physical situations related to phase separation phenomena with convection, with the main and most…

Analysis of PDEs · Mathematics 2022-02-24 Giulio Schimperna

We derive a Cahn-Hilliard-Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a…

Analysis of PDEs · Mathematics 2019-11-01 Harald Garcke , Kei Fong Lam , Robert Nürnberg , Emanuel Sitka

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…

Analysis of PDEs · Mathematics 2017-05-04 Harald Garcke , Kei Fong Lam

We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical species (oxygen and/or nutrients) that are consumed by the…

Analysis of PDEs · Mathematics 2022-06-22 Patrik Knopf , Andrea Signori

Using basic thermodynamic principles we derive a Cahn--Hilliard--Darcy model for tumour growth including nutrient diffusion, chemotaxis, active transport, adhesion, apoptosis and proliferation. The model generalises earlier models and in…

Analysis of PDEs · Mathematics 2016-06-06 Harald Garcke , Kei Fong Lam , Emanuel Sitka , Vanessa Styles

Phase field models recently gained a lot of interest in the context of tumour growth models. Typically Darcy-type flow models are coupled to Cahn-Hilliard equations. However, often Stokes or Brinkman flows are more appropriate flow models.…

Analysis of PDEs · Mathematics 2018-07-03 Matthias Ebenbeck , Harald Garcke

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…

Analysis of PDEs · Mathematics 2014-12-05 Sergio Frigeri , Maurizio Grasselli , Elisabetta Rocca

In this paper, we study an initial boundary value problem of the Cahn-Hilliard-Darcy system with a non-autonomous mass source term $S$ that models tumor growth. We first prove the existence of global weak solutions as well as the existence…

Analysis of PDEs · Mathematics 2023-07-28 Jie Jiang , Hao Wu , Songmu Zheng

A phase field model for tumour growth is introduced that is based on a Brinkman law for convective velocity fields. The model couples a convective Cahn-Hilliard equation for the evolution of the tumour to a reaction-diffusion-advection…

Analysis of PDEs · Mathematics 2021-09-07 Matthias Ebenbeck , Harald Garcke , Robert Nürnberg

In this work, we develop a structure-preserving numerical scheme for a Cahn-Hilliard-Darcy model that describes tumor growth in a fluid-saturated porous medium. First, we derive a physically consistent model from the general framework…

Numerical Analysis · Mathematics 2026-05-22 Daniel Acosta-Soba , Francisco Guillén-González , J. Rafael Rodríguez-Galván

We consider a phase-field system modelling solid tumour growth. This system consists of a Cahn-Hilliard equation coupled with a nutrient equation. The former is characterised by a degenerate mobility and a singular potential. Both equations…

Analysis of PDEs · Mathematics 2025-12-18 Cecilia Cavaterra , Matteo Fornoni , Maurizio Grasselli , Benoît Perthame

We consider a model describing the evolution of a tumor inside a host tissue in terms of the parameters $\varphi_p$, $\varphi_d$ (proliferating and dead cells, respectively), $u$ (cell velocity) and $n$ (nutrient concentration). The…

Analysis of PDEs · Mathematics 2017-09-06 Sergio Frigeri , Kei Fong Lam , Elisabetta Rocca , Giulio Schimperna

We introduce a new phase field model for tumour growth where viscoelastic effects are taken into account. The model is derived from basic thermodynamical principles and consists of a convected Cahn--Hilliard equation with source terms for…

Numerical Analysis · Mathematics 2024-06-21 Harald Garcke , Balázs Kovács , Dennis Trautwein

We study a Cahn-Hilliard-Darcy system with mass sources, which can be considered as a basic, though simplified, diffuse interface model for the evolution of tumor growth. This system is equipped with an impermeability condition for the…

Optimization and Control · Mathematics 2024-08-20 Marco Abatangelo , Cecilia Cavaterra , Maurizio Grasselli , Hao Wu

We study a phase field model proposed recently in the context of tumour growth. The model couples a Cahn-Hilliard-Brinkman (CHB) system with a elliptic reaction-diffusion equation for a nutrient. The fluid velocity, governed by the Brinkman…

Analysis of PDEs · Mathematics 2019-09-06 Matthias Ebenbeck , Kei Fong Lam
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