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Engineered biomedical nanoparticles (NP) administered via intravenous routes are prone to associate to serum proteins. The protein corona can mask the NP surface functionalization and hamper the delivery of the NP to its biological target.…

Computational Physics · Physics 2019-05-29 Federica Simonelli , Giulia Rossi , Luca Monticelli

Nanoparticles (NPs) engineered for biomedical applications are meant to be in contact with protein-rich physiological fluids. These proteins are usually adsorbed onto the NP surface, forming a swaddling layer called protein corona that…

Biological Physics · Physics 2014-07-01 M. P. Catalayud , B. Sanz , V. Raffa , C. Riggio , M. R. Ibarra , G. F. Goya

This article reports dependence of exchange bias (EB) effect on interparticle interactions in nanocrystalline Co/CoO core/shell structures, synthesized using conventional sol-gel technique. Analysis via powder X-Ray diffraction (PXRD)…

Herein, we examined the dependence of protein adsorption on the nanoparticle surface in the presence of functional groups. Our UV-visible spectrophotometry, transmission electron microscopy, infrared spectroscopy and dynamic light…

Soft Condensed Matter · Physics 2016-10-18 Ramakrishna Podila , Ran Chen , Pu Chun Ke , Apparao M. Rao

Electrostatic interactions play a fundamental role in the structure and function of proteins. Due to ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge is not constant but varies with the…

Biological Physics · Physics 2017-10-27 Anze Losdorfer Bozic , Rudolf Podgornik

The biofilms response on active attachment surfaces (submerged plant leaves) and inert attachment surfaces (biomimetic plant glass attachment surfaces) and their effects on PAHs and nitrogen transformation under the application conditions…

Cell Behavior · Quantitative Biology 2025-10-07 Xiabinchen Zhao , Liling Xia , Zhenhua Zhao

Although strong modulation of interfacial electron concentrations by the relative acidity of surface additives has been suggested, direct observation of corresponding changes in surface conductivity, crucial for understanding the role of…

Materials Science · Physics 2025-05-21 Gyu Rac Lee , Thomas Defferriere , Jinwook Kim , Han Gil Seo , Yeon Sik Jung , Harry L. Tuller

The main aim of this study is to report basic knowledge on how a protein corona (PC) could affect or modify the way in which multifunctionalized nanoparticles interact with cells. With this purpose, we have firstly optimized the development…

Nanomaterial surface states can effectively modify or even dominate their physical and chemical properties due to large surface-to-volume ratios. Such surface effects are highly dependent on particle size and ligand coverage, yet the…

Materials Science · Physics 2020-07-17 Guolei Xiang , Yan Tang , Zigeng Liu , Wei Zhu , Haitao Liu , Jiaou Wang , Guiming Zhong , Jun Li , Xun Wang

Due to the potential applications in biomedical engineering, it becomes more and more important to understand the process of engulfment and internalization of nanoparticles (NPs) by cell membranes. Despite the fact that the interaction…

Biological Physics · Physics 2023-12-12 Ke Xiao , Jing Li , Rui Ma , Chen-Xu Wu

Donor-$\pi$-acceptor (D-$\pi$-A) functionalization of MOF linkers can enhance visible-light photocatalytic activity, yet the mechanisms responsible for these effects remain unclear. Here we combine EPR spectroscopy, transient…

Interfacial interactions significantly alter the fundamental properties of water confined in mesoporous structures, with crucial implications for geological, physicochemical, and biological processes. Herein, we focused on the effect of…

DNAs charge transfer and self-assembly characteristics have made it a hallmark of molecular electronics for the past two decades. A fast and efficient charge transfer mechanism with programmable properties using DNA nanostructures is…

Materials Science · Physics 2023-07-05 Busra Demir , Hashem Mohammad , M. P. Anantram , Ersin Emre Oren

Bipolar nanopores have powerful rectification properties due to the asymmetry in the charge pattern on the wall of the nanopore. In particular, bipolar nanopores have positive and negative surface charges along the pore axis. Rectification…

Soft Condensed Matter · Physics 2020-11-25 Dávid Fertig , Mónika Valiskó , Dezső Boda

Nanoparticle (NP)-protein complexes exhibit the correct identity of NP in biological media. Therefore, protein-NP interactions should be closely explored to understand and to modulate the nature of NPs in medical implementations. This…

We describe several unexpected phenomena, caused by a solid-solid phase transition (gel-to-crystal) typical for all main classes of lipid substances - phospholipids, triglycerides, diglycerides, alkanes, etc. We discovered that this…

Materials Science · Physics 2020-08-26 Diana Cholakova , Desislava Glushkova , Slavka Tcholakova , Nikolai Denkov

Environmental fate and toxicity of microplastic particles is dominated by their surface properties. In the environment an adsorbed layer of biomolecules and natural organic matter forms the so-called eco-corona. A quantitative description…

Electrostatic interactions fundamentally govern the structure, stability, and dynamics of charged (bio)matter, yet the impact of heterogeneous and anisotropic charge distributions on the behavior of protein solutions remains elusive. Here,…

The formation of soluble hydrogen-bonding interpolymer complexes between poly(acrylic acid) (PAA) and poly(acrylic acid-co-2-acrylamido-2-methyl-1-propane sulfonic acid)-graft-poly(N, N dimethylacrylamide) (P(AA-co-AMPSA)-g-PDMAM) at pH =…

Soft Condensed Matter · Physics 2007-09-18 Maria Sotiropoulou , Frederic Bossard , Eric Balnois , Julian Oberdisse , Georgios Staikos

The last decade, nanopores have emerged as a new and interesting tool for the study of biological macromolecules like proteins and DNA. While biological pores, especially alpha-hemolysin, have been promising for the detection of DNA, their…

Biological Physics · Physics 2015-03-13 Ronald Kox , Stella Deheryan , Chang Chen , Nima Arjmandi , Liesbet Lagae , Gustaaf Borghs
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