Herein, we examined the dependence of protein adsorption on the nanoparticle surface in the presence of functional groups. Our UV-visible spectrophotometry, transmission electron microscopy, infrared spectroscopy and dynamic light scattering measurements evidently suggested that the functional groups play an important role in the formation of nanoparticle-protein corona. We found that uncoated and surfactant-free silver nanoparticles derived from a laser ablation process promoted a maximum protein (bovine serum albumin) coating due to increased changes in entropy. On the other hand, BSA displayed a lower affinity for electrostatically stabilized nanoparticles due to the constrained entropy changes.
@article{arxiv.1209.5475,
title = {Effects of surface functional groups on the formation of nanoparticle-protein corona},
author = {Ramakrishna Podila and Ran Chen and Pu Chun Ke and Apparao M. Rao},
journal= {arXiv preprint arXiv:1209.5475},
year = {2016}
}