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Nanosecond temporal resolution enables new methods for wide-field imaging like time-of-flight, gated detection, and fluorescence lifetime. The optical efficiency of existing approaches, however, presents challenges for low-light…

Fluorescence imaging is the most widely used method for unveiling the molecular composition of biological specimens. However, the weak optical emission of fluorescent probes and the tradeoff between imaging speed and sensitivity is…

Suppressing the interference of atmospheric turbulence and obtaining observation data with a high spatial resolution is an issue to be solved urgently for ground observations. One way to solve this problem is to perform a statistical…

Instrumentation and Methods for Astrophysics · Physics 2022-07-04 Hui Liu , Zhenyu Jin , Yongyuan Xiang , Kaifan Ji

Quantum optics has driven major advances in our ability to generate and detect correlations between individual photons. Its principles are now increasingly translated into nanoscale characterization techniques, enhancing spectroscopy,…

Near-field scanning optical microscopy has been an indispensable tool for designing, characterizing and understanding the functionalities of diverse nanoscale photonic devices. As the advances in fabrication technology have driven the…

Stimulated Emission Depletion (STED) microscopy has emerged as a powerful technique providing visualization of biological structures at the molecular level in living samples. In this technique, the diffraction limit is broken by selectively…

Chiral photonics opens new pathways to manipulate light-matter interactions and tailor the optical response of meta-surfaces and -materials by nanostructuring nontrivial patterns. Chirality of matter, such as that of molecules, and light,…

Optics · Physics 2022-02-16 Oliver Mey , Arash Rahimi-Iman

Highly ordered periodic arrays of silver nanoparticles have been fabricated which exhibit surface plasmon resonances in the visible spectrum. We demonstrate the ability of these structures to alter the fluorescence properties of vicinal dye…

Other Condensed Matter · Physics 2009-11-13 Nic Cade , Tom Ritman-Meer , David Richards

Even though image signals are typically defined on a regular two-dimensional grid, there also exist many scenarios where this is not the case and the amplitude of the image signal only is available for a non-regular subset of pixel…

Image and Video Processing · Electrical Eng. & Systems 2022-04-28 Jürgen Seiler , Markus Jonscher , Michael Schöberl , André Kaup

Labelfree nanoscopy encompasses optical imaging with resolution in the 100 nm range using visible wavelengths. Here, we present a labelfree nanoscopy method that combines Fourier ptychography with waveguide microscopy to realize a…

Fourier ptychographic microscopy enables gigapixel-scale imaging, with both large field-of-view and high resolution. Using a set of low-resolution images that are recorded under varying illumination angles, the goal is to computationally…

Signal Processing · Electrical Eng. & Systems 2018-03-13 Emrah Bostan , Mahdi Soltanolkotabi , David Ren , Laura Waller

The ability to spatially and temporally map nanoscale environments in situ over extended timescales would be transformative for biology, biomedicine, and bioengineering. All nanometer objects, from nanoparticles down to single proteins,…

Optics · Physics 2023-10-04 Guangjie Cui , Do Young Kim , Di Zu , Guanbo Chai , Somin Eunice Lee

We experimentally demonstrate how to solve the phase problem of diffraction using multi-wave interference with standard diffraction experimental setups without the need for taking any auxiliary data. In particular, we show that the phases…

Optics · Physics 2021-05-04 M. Fally , Y. Tomita , A. Fimia , R. F. Madrigal , J. Guo , J. Kohlbrecher , J. Klepp

Lens-free on-chip digital holographic microscopy (LFOCDHM) is a modern imaging technique whereby the sample is placed directly onto or very close to the digital sensor, and illuminated by a partially coherent source located far above it.…

Optics · Physics 2019-06-17 Jialin Zhang , Jiasong Sun , Qian Chen , Chao Zuo

On-chip optical architectures that enable angle-resolved spectroscopy are essential for advancing photonic platforms towards low-volume, scalable, and cryo-compatible devices. Here, we introduce spatially resolved momentum-space imaging…

Patient-specific therapies require that cells be manufactured in multiple batches of small volumes, making it a challenge for conventional modes of quality control. The added complexity of inherent variability (even within batches)…

Biological Physics · Physics 2018-04-17 Derrick Yong , Ahmad Amirul Abdul Rahim , Jesslyn Ong , May Win Naing

Optical phase-space functions describe spatial and angular information simultaneously; examples include light fields in ray optics and Wigner functions in wave optics. Measurement of phase-space enables digital refocusing, aberration…

Optics · Physics 2017-08-02 Hsiou-Yuan Liu , Jingshan Zhong , Laura Waller

We consider a variational model for single-image super-resolution based on the assumption that the gradient of the target image is sparse. We enforce this assumption by considering both an isotropic and an anisotropic $\ell^0$…

Image and Video Processing · Electrical Eng. & Systems 2020-12-17 Pasquale Cascarano , Luca Calatroni , Elena Loli Piccolomini

Super-resolution microscopy has revolutionized optical fluorescence imaging by improving 3D resolution by 1-2 orders of magnitude. While different methods can successfully increase the resolution, all methods share significant differences…

Biological Physics · Physics 2015-01-26 Thomas Pengo , Nicolas Olivier , Suliana Manley

We present a detailed investigation of the near-field optical response of core-shell nanoparticles using Fourier-demodulated full-wave simulations, revealing significant modifications to established contrast mechanisms in scattering-type…