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The function of many membrane-enclosed intracellular structures relies on release of diffusing particles that exit through narrow pores or channels in the membrane. The rate of release varies with pore size, density, and length of the…

Biological Physics · Physics 2023-02-08 Zitao Yang , Elena F. Koslover

In various models and systems involving the escape of periodically forced particle from the potential well, a common pattern is observed. Namely, the minimal forcing amplitude required for the escape exhibits sharp minimum for the…

Chaotic Dynamics · Physics 2018-12-31 O. V. Gendelman , G. Karmi

We consider a model of surface-mediated diffusion with alternating phases of pure bulk and surface diffusion. For this process, we compute the mean exit time from a disk through a hole on the circle. We develop a spectral approach to this…

Mathematical Physics · Physics 2014-04-24 O. Bénichou , D. S. Grebenkov , L. Hillairet , L. Phun , R. Voituriez , M. Zinsmeister

When a flux of Brownian particles is injected in a narrow window located on the surface of a bounded domain, these particles diffuse and can eventually escape through a cluster of narrow windows. At steady-state, we compute asymptotically…

Analysis of PDEs · Mathematics 2024-07-31 Frédéric Paquin-Lefebvre , David Holcman

New theorems for the moments of the first passage time of one dimensional nonlinear stochastic processes with an entrance boundary are formulated. This important class of one dimensional stochastic processes results among others from…

Analysis of PDEs · Mathematics 2020-04-22 Leo Dostal , Navaratnam Sri Namachchivaya

Constrained diffusions in convex polyhedral domains with a general oblique reflection field, and with a diffusion coefficient scaled by a small parameter, are considered. Using an interior Dirichlet heat kernel lower bound estimate for…

Probability · Mathematics 2013-08-19 Amarjit Budhiraja , Zhen-Qing Chen

The diffusive non-Markovian motion over a single-well potential barrier in the presence of a weak sinusoidal time-modulation is studied. We found non-monotonic dependence of the mean escape time from the barrier on a frequency of the…

Statistical Mechanics · Physics 2015-05-30 V. M. Kolomietz , S. V. Radionov

A general topic of current interest is the analysis of diffusion problems in singularly perturbed domains with small interior targets or traps (the narrow capture problem). One major application is to intracellular diffusion, where the…

Statistical Mechanics · Physics 2022-04-13 Paul C. Bressloff

We establish general moment estimates for the discrete and continuous exit times of a general It\^o process in terms of the distance to the boundary. These estimates serve as intermediate steps to obtain strong convergence results for the…

Probability · Mathematics 2014-09-10 Bruno Bouchard , Stefan Geiss , Emmanuel Gobet

We investigate simple one-dimensional driven diffusive systems with open boundaries. We are interested in the average on-site residence time defined as the time a particle spends on a given site before moving on to the next site. Using…

Biological Physics · Physics 2016-01-20 Joris J. B. Messelink , Robbie Rens , Mahsa Vahabi , Fred C. MacKintosh , Abhinav Sharma

We consider a one-dimensional loop of circumference $L$ crossed by a constant magnetic flux $\Phi$ and connected to an infinite lead with coupling parameter $\epsilon$. Assuming that the initial state $\psi_0$ of the particle is confined…

Quantum Physics · Physics 2015-05-30 Ph. A. Jacquet

We derive a singular diffusion limit for the position of a tagged particle in zero range interacting particle processes on a one dimensional torus with a Sinai-type random environment via two steps. In the first step, a regularization is…

Probability · Mathematics 2025-02-25 Marcel Hudiani , Claudio Landim , Sunder Sethuraman

We investigate theoretically and experimentally the first passage-time properties of a spherical Brownian particle that is harmonically trapped at thermal equilibrium in a fluid at constant temperature. By using the overdamped version of…

Statistical Mechanics · Physics 2026-05-26 Brandon R. Ferrer , Juan Ruben Gomez-Solano

We consider a run-and-tumble particle on a finite interval $[a,b]$ with two absorbing end points. The particle has an internal velocity state that switches between three values $v,0,-v$ at exponential times, thus incorporating positive…

Statistical Mechanics · Physics 2026-02-02 Pascal Grange , Linglong Yuan

The distribution of exit times is computed for a Brownian particle in spherically symmetric two- dimensional domains (disks, angular sectors, annuli) and in rectangles that contain an exit on their boundary. The governing partial…

Computational Physics · Physics 2014-09-29 J. -F. Rupprecht , O. Bénichou , D. S. Grebenkov , R. Voituriez

We formulate a scaling theory for the long-time diffusive motion in a space occluded by a high density of moving obstacles in dimensions 1, 2 and 3. Our tracers diffuse anomalously over many decades in time, before reaching a diffusive…

Statistical Mechanics · Physics 2024-10-22 H. Bendekgey , G. Huber , D. Yllanes

Second initial boundary problem in narrow domains of width $\epsilon\ll 1$ for linear second order differential equations with nonlinear boundary conditions is considered in this paper. Using probabilistic methods we show that the solution…

Probability · Mathematics 2010-11-30 Mark Freidlin , Konstantinos Spiliopoulos

In this paper we investigate deterministic diffusion in systems which are spatially extended in certain directions but are restricted in size and open in other directions, consequently particles can escape. We introduce besides the…

chao-dyn · Physics 2016-08-31 Z. Kaufmann , H. Lustfeld , A. Nemeth , P. Szepfalusy

It is now well established that microswimmers can be sorted or segregated fabricating suitable microfluidic devices or using external fields. A natural question is how these techniques can be employed for dividing swimmers of different…

Statistical Mechanics · Physics 2020-11-04 Matteo Paoluzzi , Luca Angelani , Andrea Puglisi

We study statistics of first passage inside a cone in arbitrary spatial dimension. The probability that a diffusing particle avoids the cone boundary decays algebraically with time. The decay exponent depends on two variables: the opening…

Statistical Mechanics · Physics 2010-11-19 E. Ben-Naim , P. L. Krapivsky
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