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Cells have evolved efficient strategies to probe their surroundings and navigate through complex environments. From metastatic spread in the body to swimming cells in porous materials, escape through narrow constrictions - a key component…

Biological Physics · Physics 2021-10-04 Mathieu Souzy , Antoine Allard , Jean-François Louf , Matteo Contino , Idan Tuval , Marco Polin

The narrow escape problem consists of deriving the asymptotic expansion of the solution of a drift-diffusion equation with the Dirichlet boundary condition on a small absorbing part of the boundary and the Neumann boundary condition on the…

Analysis of PDEs · Mathematics 2010-03-12 Habib Ammari , Kostis Kalimeris , Hyeonbae Kang , Hyundae Lee

This paper summarises an investigation of the statistical properties of orbits escaping from three different two-degree-of-freedom Hamiltonian systems which exhibit global stochasticity. Each H=H_{0}+eH', with H_{0} integrable and eH' a…

Astrophysics · Physics 2009-10-31 Henry E. Kandrup , Christos Siopis , George Contopoulos , Rudolf Dvorak

Using martingale theory, we compute, in very few lines, exact analytical expressions for various first-exit-time statistics associated with one-dimensional biased diffusion. Examples include the distribution for the first-exit time from an…

Statistical Mechanics · Physics 2024-05-13 Yonathan Sarmiento , Debraj Das , Édgar Roldán

Cellular networks are often composed of thin tubules connecting much larger node compartments. These structures serve for active or diffusion transport of proteins. Examples are glial networks in the brain, the endoplasmic reticulum in…

Soft Condensed Matter · Physics 2024-07-31 Frédéric Paquin-Lefebvre , Kanishka Basnayake , David Holcman

We survey recent results on first-passage processes in unbounded cones and their applications to ordering of particles undergoing Brownian motion in one dimension. We first discuss the survival probability S(t) that a diffusing particle, in…

Statistical Mechanics · Physics 2013-06-14 E. Ben-Naim , P. L. Krapivsky

Many problems in physics, biology, and economics depend upon the duration of time required for a diffusing particle to cross a boundary. As such, calculations of the distribution of first passage time, and in particular the mean first…

Biological Physics · Physics 2021-05-26 Matthew J Simpson , Daniel J Vandenheuvel , Joshua M Wilson , Scott W McCue , Elliot J Carr

We determine the rate of escape from a potential well, and the diffusion coefficient in a periodic potential, of a random walker that moves under the influence of the potential in between successive collisions with the heat bath. In the…

Statistical Mechanics · Physics 2016-09-05 Massimo Pica Ciamarra , Antonio Piscitelli

The escape dynamics of sticky particles from textured surfaces is poorly understood despite importance to various scientific and technological domains. In this work, we address this challenge by investigating the escape time of adsorbates…

Statistical Mechanics · Physics 2025-07-15 Yuval Scher , Shlomi Reuveni , Denis S. Grebenkov

Intracellular transport in living cells is often spatially inhomogeneous with an accelerated effective diffusion close to the cell membrane and a ballistic motion away from the centrosome due to active transport along actin filaments and…

Statistical Mechanics · Physics 2021-10-22 Matthieu Mangeat , Heiko Rieger

We study exit times from time-dependent domains under joint perturbations of the trajectory and the domain. Representing a moving domain by a continuous barrier $\Phi$ on space-time, we reduce the exit problem to a one-dimensional…

Probability · Mathematics 2026-04-06 Tristan Guillaume

This paper investigates the exit-time problem for time-inhomogeneous diffusion processes. The focus is on the small-noise behavior of the exit time from a bounded positively invariant domain. We demonstrate that, when the drift and…

Probability · Mathematics 2025-01-22 Ashot Aleksian , Stéphane Villeneuve

The diffusion equation is the primary tool to study the movement dynamics of a free Brownian particle, but when spatial heterogeneities in the form of permeable interfaces are present, no fundamental equation has been derived. Here we…

Statistical Mechanics · Physics 2022-09-14 Toby Kay , Luca Giuggioli

The purpose of this paper is to consider the exit-time problem for a finite-range Markov jump process, i.e, the distance the particle can jump is bounded independent of its location. Such jump diffusions are expedient models for anomalous…

Probability · Mathematics 2015-01-29 Nathanial Burch , Marta D'Elia , R. B. Lehoucq

The problem of the time required for a diffusing molecule, within a large bounded domain, to first locate a small target is prevalent in biological modeling. Here we study this problem for a small spherical target. We develop uniform in…

Biological Physics · Physics 2013-08-06 Samuel A. Isaacson , Jay Newby

We explore the diffusion process in the non-Markovian spatio-temporal noise.%the escape rate problem in the non-Markovian spatio-temporal random noise. There is a non-trivial short memory regime, i.e., the Markovian limit characterized by a…

Statistical Mechanics · Physics 2009-11-13 Takaaki Monnai , Ayumu Sugita , Katsuhiro Nakamura

We consider an anisotropic needle-like Brownian particle with nematic symmetry confined in a $2D$ domain. For this system, the coupling of translational and rotational diffusion makes the process ${\bf x} (t)$ of the positions of the…

Statistical Mechanics · Physics 2017-02-08 Nicolas Levernier , Olivier Bénichou , Raphaël Voituriez

We consider the general problem of the first passage distribution of particles whose displacements are subject to time delays. We show that this problem gives rise to a \emph{propagation-dispersion equation} which is obtained as the…

Statistical Mechanics · Physics 2009-11-10 Jean Pierre Boon , Patrick Grosfils , James F. Lutsko

Despite having been studied for decades, first passage processes remain an active area of research. In this contribution we examine a particle diffusing in an annulus with an inner absorbing boundary and an outer reflective boundary. We…

Statistical Mechanics · Physics 2022-10-05 Charles Antoine , Julian Talbot

In this paper, some initial-boundary-value problems for the time-fractional diffusion equation are first considered in open bounded n-dimensional domains. In particular, the maximum principle well-known for the PDEs of elliptic and…

Analysis of PDEs · Mathematics 2012-05-08 Yuri Luchko