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We report the experimental super-resolution of pairs of point-like fluorescent sources using a modified image inversion interferometer microscope. The technique is inspired by recent developments in the application of quantum parameter…

In medical image segmentation, uncertainty estimates are often reported but rarely used to guide decisions. We study the missing step: how uncertainty maps are converted into actionable policies such as accepting, flagging, or deferring…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Saket Maganti

We give a principled method for decomposing the predictive uncertainty of a model into aleatoric and epistemic components with explicit semantics relating them to the real-world data distribution. While many works in the literature have…

Machine Learning · Computer Science 2024-12-30 Gustaf Ahdritz , Aravind Gollakota , Parikshit Gopalan , Charlotte Peale , Udi Wieder

The article demonstrates some less known principles of image build-up in diffractive microscopy and their usage in analysis unravelling the smallest localized information about the original object - an electromagnetic centroid. In…

Medical Physics · Physics 2016-12-15 Renata Rychtarikova , Georg Steiner , Michael B. Fischer , Dalibor Stys

We present a method to estimate dense depth by optimizing a sparse set of points such that their diffusion into a depth map minimizes a multi-view reprojection error from RGB supervision. We optimize point positions, depths, and weights…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Numair Khan , Min H. Kim , James Tompkin

Robust and accurate camera calibration is essential for 3D reconstruction in light microscopy under circular motion. Conventional methods require either accurate key point matching or precise segmentation of the axial-view images. Both…

Computer Vision and Pattern Recognition · Computer Science 2019-10-31 Yuanhao Guo , Fons J. Verbeek , Ge Yang

Computational image reconstruction algorithms generally produce a single image without any measure of uncertainty or confidence. Regularized Maximum Likelihood (RML) and feed-forward deep learning approaches for inverse problems typically…

Machine Learning · Computer Science 2020-12-18 He Sun , Katherine L. Bouman

Datasets collected from the open world unavoidably suffer from various forms of randomness or noiseness, leading to the ubiquity of aleatoric (data) uncertainty. Quantifying such uncertainty is particularly pivotal for object detection,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Peng Cui , Guande He , Dan Zhang , Zhijie Deng , Yinpeng Dong , Jun Zhu

In safety-critical applications like medical diagnosis, certainty associated with a model's prediction is just as important as its accuracy. Consequently, uncertainty estimation and reduction play a crucial role. Uncertainty in predictions…

Image and Video Processing · Electrical Eng. & Systems 2023-09-12 Abhishek Singh Sambyal , Narayanan C. Krishnan , Deepti R. Bathula

Multisource image analysis that leverages complementary spectral, spatial, and structural information benefits fine-grained object recognition that aims to classify an object into one of many similar subcategories. However, for multisource…

Computer Vision and Pattern Recognition · Computer Science 2021-05-27 Bulut Aygunes , Ramazan Gokberk Cinbis , Selim Aksoy

Echocardiography plays a fundamental role in the extraction of important clinical parameters (e.g. left ventricular volume and ejection fraction) required to determine the presence and severity of heart-related conditions. When deploying…

Computer Vision and Pattern Recognition · Computer Science 2025-02-19 Thierry Judge , Olivier Bernard , Woo-Jin Cho Kim , Alberto Gomez , Arian Beqiri , Agisilaos Chartsias , Pierre-Marc Jodoin

Accurate camera calibration is a precondition for many computer vision applications. Calibration errors, such as wrong model assumptions or imprecise parameter estimation, can deteriorate a system's overall performance, making the reliable…

Computer Vision and Pattern Recognition · Computer Science 2021-07-29 Annika Hagemann , Moritz Knorr , Holger Janssen , Christoph Stiller

Standard deviation measurements of intensity profiles of stationary single fluorescent molecules are useful for studying axial localization, molecular orientation, and a fluorescence imaging system's spatial resolution. Here we report on…

Quantitative Methods · Quantitative Biology 2015-05-13 Michael C. DeSantis , Shawn H. DeCenzo , Je-Luen Li , Y. M. Wang

Many microscopy applications are limited by the total amount of usable light and are consequently challenged by the resulting levels of noise in the acquired images. This problem is often addressed via (supervised) deep learning based…

Image and Video Processing · Electrical Eng. & Systems 2020-08-20 Anna S. Goncharova , Alf Honigmann , Florian Jug , Alexander Krull

Self-calibrating and dual-slope measurements have been used in the field of diffuse optics for robust assessment of absolute values or temporal changes in the optical properties of highly scattering media and biological tissue. These…

Optics · Physics 2025-05-05 Giles Blaney , Angelo Sassaroli , Tapan Das , Sergio Fantini

Uncertainty quantification is essential for scientific analysis, as it allows for the evaluation and interpretation of variability and reliability in complex systems and datasets. In their original form, multivariate statistical regression…

How microorganisms respond to and interact with their environment can vary significantly from individual to individual, which can have important microbiological and ecological implications. However, most microscopy techniques can only…

Counting cells in fluorescent microscopy is a tedious, time-consuming task that researchers have to accomplish to assess the effects of different experimental conditions on biological structures of interest. Although such objects are…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 R. Morelli , L. Clissa , M. Dalla , M. Luppi , L. Rinaldi , A. Zoccoli

Reliable quantification of uncertainty in Mobile Laser Scanning (MLS) point clouds is essential for ensuring the accuracy and credibility of downstream applications such as 3D mapping, modeling, and change analysis. Traditional backward…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Ziyang Xu , Olaf Wysocki , Christoph Holst

Using Time-Correlated Single Photon Counting (TCSPC) for the purpose of fluorescence lifetime measurements is usually limited in speed due to pile-up. With modern instrumentation this limitation can be lifted significantly but some…

Data Analysis, Statistics and Probability · Physics 2018-05-23 Matthias Patting , Paja Reisch , Marcus Sackrow , Rhys Dowler , Marcelle Koenig , Michael Wahl