Related papers: Optimal Trajectories of Brain State Transitions
Neuronal networks alternate between high- and low-activity regimes, known as up and down states. They also display rhythmic patterns essential for perception, memory consolidation, and sensory processing. Despite their importance, the…
Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence…
Understanding the neural mechanisms underlying the transitions between different states of consciousness is a fundamental challenge in neuroscience. Thus, we investigate the underlying drivers of changes during the resting-state dynamics of…
Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that…
It has been said that complexity lies between order and disorder. In the case of brain activity, and physiology in general, complexity issues are being considered with increased emphasis. We sought to identify features of brain organization…
Traditional approaches to understanding the brain's resilience to neuropathology have identified neurophysiological variables, often described as brain or cognitive 'reserve,' associated with better outcomes. However, mechanisms of function…
Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of…
The ability to effectively control brain dynamics holds great promise for the enhancement of cognitive function in humans, and the betterment of their quality of life. Yet, successfully controlling dynamics in neural systems is challenging,…
Working memory plays a crucial role in various aspects of human life. Therefore, it has been an area of interest in different research studies, especially neuroscience. The neuroscientists investigating working memory have primarily…
The brain is an intricately structured organ responsible for the rich emergent dynamics that support the complex cognitive functions we enjoy as humans. With around $10^{11}$ neurons and $10^{15}$ synapses, understanding how the human brain…
Human brain dynamics can be profitably viewed through the lens of statistical mechanics, where neurophysiological activity evolves around and between local attractors representing preferred mental states. Many physically-inspired models of…
A grand challenge in modern neuroscience is to bridge the gap between the detailed mapping of microscale neural circuits and mechanistic understanding of cognitive functions. While extensive knowledge exists about neuronal connectivity and…
The cognitive states have broadly been divided into waking, rapid eye movement sleep and non-REMS. Although the mechanism of state transition is unknown, it has been proposed that functional activation/deactivation among different brain…
We seek general principles of the structure of the cellular collective activity associated with conscious awareness. Can we obtain evidence for features of the optimal brain organization that allows for adequate processing of stimuli and…
One of the central aims of neuroscience is to reliably predict the behavioral response of an organism using its neural activity. If possible, this implies we can causally manipulate the neural response and design brain-computer-interface…
The brain can be considered as a system that dynamically optimizes the structure of anatomical connections based on the efficiency requirements of functional connectivity. To illustrate the power of this principle in organizing the…
We present a new paradigm in the study of brain mental dynamics on the basis of the stable transient activity neural networks observed in experiments. This new approach is in contrast to traditional system analysis usually adopted in…
Conventional neuroimaging analyses have revealed the computational specificity of localized brain regions, exploiting the power of the subtraction technique in fMRI and event-related potential analyses in EEG. Moving beyond this convention,…
Synchronization of brain activity fluctuations is believed to represent communication between spatially distant neural processes. These inter-areal functional interactions develop in the background of a complex network of axonal connections…
The brain is a non-equilibrium system whose dynamics change in different brain states, such as wakefulness and deep sleep. Thermodynamics provides the tools for revealing these non-equilibrium dynamics. We used violations of the…