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Background: Drug development is often inefficient, costly and lengthy, yet it is essential for evaluating the safety and efficacy of new interventions. Compared with other disease areas, this is particularly true for Phase II / III cancer…

Methodology · Statistics 2024-05-13 Abigail Burdon , Thomas Jaki , Xijin Chen , Pavel Mozgunov , Haiyan Zheng , Richard Baird

This work aims at improving the quality of structural variant prediction from the mapped reads of a sequenced genome. We suggest a new model based on cluster editing in weighted graphs and introduce a new heuristic algorithm that allows to…

Data Structures and Algorithms · Computer Science 2013-10-15 Thomas Bellitto , Tobias Marschall , Alexander Schönhuth , Gunnar W. Klau

Sequential recommendation aims to leverage users' historical behaviors to predict their next interaction. Existing works have not yet addressed two main challenges in sequential recommendation. First, user behaviors in their rich historical…

Information Retrieval · Computer Science 2023-07-27 Jianxin Chang , Chen Gao , Yu Zheng , Yiqun Hui , Yanan Niu , Yang Song , Depeng Jin , Yong Li

Neural compression is the application of neural networks and other machine learning methods to data compression. Recent advances in statistical machine learning have opened up new possibilities for data compression, allowing compression…

Machine Learning · Computer Science 2023-08-22 Yibo Yang , Stephan Mandt , Lucas Theis

Linguistic steganography provides convenient implementation to hide messages, particularly with the emergence of AI generation technology. The potential abuse of this technology raises security concerns within societies, calling for…

Cryptography and Security · Computer Science 2024-05-16 Minhao Bai. Jinshuai Yang , Kaiyi Pang , Huili Wang , Yongfeng Huang

Generative Adversarial Networks (GANs) have been workhorse generative models for last many years, especially in the research field of computer vision. Accordingly, there have been many significant advancements in the theory and application…

Computer Vision and Pattern Recognition · Computer Science 2023-11-03 Hrishikesh Sharma

Genome sequence analysis, which examines the DNA sequences of organisms, drives advances in many critical medical and biotechnological fields. Given its importance and the exponentially growing volumes of genomic sequence data, there are…

In recent years, we have witnessed a dramatic data explosion in genomics, thanks to the improvement in sequencing technologies and the drastically decreasing costs. We are entering the era of millions of available genomes. Notably, each…

Other Quantitative Biology · Quantitative Biology 2018-03-28 Ka-Chun Wong

In this paper we describe a new technique for the comparison of populations of DNA strands. Comparison is vital to the study of ecological systems, at both the micro and macro scales. Existing methods make use of DNA sequencing and cloning,…

Biomolecules · Quantitative Biology 2008-07-02 Dennis Shasha , Martyn Amos

This work proposes a novel approach to evaluate and analyze the behavior of multi-population parallel genetic algorithms (PGAs) when running on a cluster of multi-core processors. In particular, we deeply study their numerical and…

Neural and Evolutionary Computing · Computer Science 2025-08-05 Tomohiro Harada , Enrique Alba , Gabriel Luque

DNA microarrays are a relatively new technology that can simultaneously measure the expression level of thousands of genes. They have become an important tool for a wide variety of biological experiments. One of the most common goals of DNA…

Methodology · Statistics 2013-07-02 Eric Bair

In this paper, we review recent developments and the role of Graph Neural Networks (GNNs) in computational drug discovery, including molecule generation, molecular property prediction, and drug-drug interaction prediction. By summarizing…

Machine Learning · Computer Science 2025-06-03 Zhengyu Fang , Xiaoge Zhang , Anyin Zhao , Xiao Li , Huiyuan Chen , Jing Li

Parallelization techniques have become ubiquitous for accelerating inference and training of deep neural networks. Despite this, several operations are still performed in a sequential manner. For instance, the forward and backward passes…

Machine Learning · Computer Science 2023-10-30 Federico Danieli , Miguel Sarabia , Xavier Suau , Pau Rodríguez , Luca Zappella

Graph Neural Networks (GNNs) have exploded onto the machine learning scene in recent years owing to their capability to model and learn from graph-structured data. Such an ability has strong implications in a wide variety of fields whose…

Machine Learning · Computer Science 2021-07-26 Sergi Abadal , Akshay Jain , Robert Guirado , Jorge López-Alonso , Eduard Alarcón

Network Service Chaining (NSC) is a service deployment concept that promises increased flexibility and cost efficiency for future carrier networks. NSC has received considerable attention in the standardization and research communities…

Networking and Internet Architecture · Computer Science 2014-02-14 Wolfgang John , Kostas Pentikousis , George Agapiou , Eduardo Jacob , Mario Kind , Antonio Manzalini , Fulvio Risso , Dimitri Staessens , Rebecca Steinert , Catalin Meirosu

The continuous increase of data generated provides enormous possibilities of both public and private companies. The management of this mass of data or big data will play a crucial role in the society of the future, as it finds applications…

Computers and Society · Computer Science 2015-01-15 Fatima El Jamiy , Abderrahmane Daif , Mohamed Azouazi , Abdelaziz Marzak

Technical signs of progress during the last decades has led to a situation in which the accumulation of genome sequence data is increasingly fast and cheap. The huge amount of molecular data available nowadays can help addressing new and…

Genomics · Quantitative Biology 2017-05-02 Christophe Guyeux , Bashar Al-Nuaimi , Bassam AlKindy , Jean-François Couchot , Michel Salomon

The recent development of quantum computing, which uses entanglement, superposition, and other quantum fundamental concepts, can provide substantial processing advantages over traditional computing. These quantum features help solve many…

Many problems in computational neuroscience, neuroinformatics, pattern/image recognition, signal processing and machine learning generate massive amounts of multidimensional data with multiple aspects and high dimensionality. Tensors (i.e.,…

Emerging Technologies · Computer Science 2014-08-26 Andrzej Cichocki

Computational analysis methods including machine learning have a significant impact in the fields of genomics and medicine. High-throughput gene expression analysis methods such as microarray technology and RNA sequencing produce enormous…

Genomics · Quantitative Biology 2022-09-28 Nikita Bhandari , Rahee Walambe , Ketan Kotecha , Satyajeet Khare