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Motivated by an ongoing collaboration with clinical oncologists and pathologists, we develop a hybrid partial differential equation--ordinary differential equation (PDE--ODE) framework that captures (i) competition between susceptible and…

Analysis of PDEs · Mathematics 2026-01-26 Jiguang Yu , Louis Shuo Wang , Zonghao Liu , Jingfeng Liu

This paper is devoted to the design and analysis of a numerical algorithm for approximating solutions of a degenerate cross-diffusion system, which models particular instances of taxis-type migration processes under local sensing…

Numerical Analysis · Mathematics 2025-10-09 Juan Vicente Gutiérrez-Santacreu

We study the (generalized) one-dimensional population model developed by Anguige \& Schmeiser [1], which reflects cell-cell adhesion and volume filling under no-flux boundary condition. In this generalized model, depending on the adhesion…

Analysis of PDEs · Mathematics 2024-09-11 Hyung Jun Choi , Seonghak Kim , Youngwoo Koh

We consider the chemotaxis-fluid system \begin{align}\label{star}\tag{$\diamondsuit$} \left\{ \begin{array}{r@{\,}c@{\,}c@{\ }l@{\quad}l@{\quad}l@{\,}c} n_{t}&+&u\cdot\!\nabla n&=\Delta n^m-\nabla\!\cdot(n\nabla c),\ &x\in\Omega,& t>0,\\…

Analysis of PDEs · Mathematics 2018-08-06 Tobias Black

In this paper we study a recently derived mathematical model for nonlinear propagation of waves in the atmosphere, for which we establish the local well-posedness in the setting of classical solutions. This is achieved by formulating the…

Analysis of PDEs · Mathematics 2024-04-26 Bogdan-Vasile Matioc , Luigi Roberti

Strong experimental evidence has indicated that tumor growth belongs to the molecular beam epitaxy universality class. This type of growth is characterized by the constraint of cell proliferation to the tumor border, and surface diffusion…

Quantitative Methods · Quantitative Biology 2009-11-13 Carlos Escudero

In this paper we consider chemotherapy in a spatial model of tumor growth. The model, which is of reaction-diffusion type, takes into account the complex interactions between the tumor and surrounding stromal cells by including densities of…

In this paper we study a cross-diffusion system whose coefficient matrix is non-symmetric and degenerate. The system arises in the study of tissue growth with autophagy. The existence of a weak solution is established. We also investigate…

Analysis of PDEs · Mathematics 2021-06-22 Jian-Guo Liu , Xiangsheng Xu

In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…

Analysis of PDEs · Mathematics 2021-08-31 Xu'an Dou , Jian-Guo Liu , Zhennan Zhou

Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…

Tissues and Organs · Quantitative Biology 2019-07-16 Joe Eyles , John F. King , Vanessa Styles

We revisit a classical continuum model for the diffusion of multiple species with size-exclusion constraint, which leads to a degenerate nonlinear cross-diffusion system. The purpose of this article is twofold: first, it aims at a…

Analysis of PDEs · Mathematics 2022-08-04 Katharina Hopf , Martin Burger

Motivated by the incompressible limit of a cell density model, we propose a free boundary tumor growth model where the pressure satisfies an obstacle problem on an evolving domain $\Omega(t)$, and the coincidence set $\Lambda(t)$ captures…

Analysis of PDEs · Mathematics 2023-11-01 Xu'an Dou , Chengfeng Shen , Zhennan Zhou

In this work, we study the Neumann initial boundary value problem for a three-component chemotaxis model in any dimensional bounded and smooth domains; this model is used to describe the branching of capillary sprouts during angiogenesis.…

Analysis of PDEs · Mathematics 2023-01-10 Jiawei Chu , Haiyang Jin , Tian Xiang

The aim of this paper is to prove global in time existence of weak solutions for a viscoelastic phase separation. We consider the case with singular potentials and degenerate mobilities. Our model couples the diffusive interface model with…

Analysis of PDEs · Mathematics 2022-08-31 Aaron Brunk , Maria Lukacova-Medvidova

In this article we prove the global existence of weak solutions for a diffuse interface model in a bounded domain (both in 2D and 3D) involving incompressible magnetic fluids with unmatched densities. The model couples the incompressible…

Analysis of PDEs · Mathematics 2021-06-09 Martin Kalousek , Sourav Mitra , Anja Schlömerkemper

In this paper, we consider the Dirichlet problem of three-dimensional inhomogeneous incompressible micropolar equations with density-dependent viscosity. Under the assumption that the coefficients are power functions of the density, we…

Analysis of PDEs · Mathematics 2025-05-13 Peng Lu , Yuanyuan Qiao

We introduce an extension of the concept of renormalised solutions for entropy-dissipating reaction-diffusion systems due to J. Fischer (Arch. Ration. Mech. Anal. 218, 2015) to systems coupled by nonlinear interface conditions. For this…

Analysis of PDEs · Mathematics 2026-02-26 Katharina Hopf , Bao Quoc Tang

We study the asymptotic behaviour of a system of nonlinear reaction--diffusion--advection equations in a domain consisting of two bulk regions connected via microscopic channels distributed within a thin membrane. Both the width of the…

Analysis of PDEs · Mathematics 2025-12-15 Lucas M. Fix , Gianna Götzmann , Malte A. Peter , Jan-F. Pietschmann

This paper studies the existence and asymptotic behavior of global weak solutions for a thin film equation with insoluble surfactant under the influence of gravitational, capillary and van der Waals forces. We prove the existence of global…

Analysis of PDEs · Mathematics 2019-08-21 Gabriele Bruell , Rafael Granero-Belinchón

We study a nonlinear system coupling the Darcy-Forchheimer-Brinkman equations with a convection-diffusion-reaction equation, arising in reactive transport through porous media. The model features a nonlinear viscosity coupling, Forchheimer…

Analysis of PDEs · Mathematics 2026-01-27 Sahil Kundu , Manmohan Vashisth , Manoranjan Mishra