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Recent work has attempted to use whole-genome sequence data from pathogens to reconstruct the transmission trees linking infectors and infectees in outbreaks. However, transmission trees from one outbreak do not generalize to future…

Quantitative Methods · Quantitative Biology 2023-10-24 Eben Kenah , Tom Britton , M. Elizabeth Halloran , Ira M. Longini

Diffusion models surpass previous generative models in sample quality and training stability. Recent works have shown the advantages of diffusion models in improving reinforcement learning (RL) solutions. This survey aims to provide an…

Machine Learning · Computer Science 2024-02-26 Zhengbang Zhu , Hanye Zhao , Haoran He , Yichao Zhong , Shenyu Zhang , Haoquan Guo , Tingting Chen , Weinan Zhang

Protein translocation in cells has been modelled by \emph{Brownian ratchets}. In such models, the protein diffuses through a nanopore. On one side of the pore, ratcheting molecules bind to the protein and hinder it to diffuse out of the…

Probability · Mathematics 2009-12-07 Andrej Depperschmidt , Peter Pfaffelhuber

We propose a probabilistic graphical model realizing a minimal encoding of real variables dependencies based on possibly incomplete observation and an empirical cumulative distribution function per variable. The target application is a…

Probability · Mathematics 2015-08-28 Victorin Martin , Jean-Marc Lasgouttes , Cyril Furtlehner

Predicting protein functional characteristics from structure remains a central problem in protein science, with broad implications from understanding the mechanisms of disease to designing novel therapeutics. Unfortunately, current machine…

Biological Physics · Physics 2024-09-30 Kevin Borisiak , Gian Marco Visani , Armita Nourmohammad

A forward model of matter and biased tracers at arbitrary order in Lagrangian perturbation theory (LPT) is presented. The forward model contains the complete LPT displacement field at any given order in perturbations, as well as all…

Cosmology and Nongalactic Astrophysics · Physics 2021-10-04 Fabian Schmidt

Feature-based transfer is one of the most effective methodologies for transfer learning. Existing studies usually assume that the learned new feature representation is \emph{domain-invariant}, and thus train a transfer model $\mathcal{M}$…

Machine Learning · Computer Science 2022-04-22 Pengfei Wei , Xinghua Qu , Yew Soon Ong , Zejun Ma

Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of amino acids. Ribosomes bound to mRNA move unidirectionally,…

Subcellular Processes · Quantitative Biology 2022-01-19 Olivier Dauloudet , Izaak Neri , Jean-Charles Walter , Jérôme Dorignac , Frédéric Geniet , Andrea Parmeggiani

Vehicle GPS trajectories provide valuable movement information that supports various downstream tasks and applications. A desirable trajectory learning model should be able to transfer across regions and tasks without retraining, avoiding…

Machine Learning · Computer Science 2025-05-20 Tonglong Wei , Yan Lin , Zeyu Zhou , Haomin Wen , Jilin Hu , Shengnan Guo , Youfang Lin , Gao Cong , Huaiyu Wan

Distributional reinforcement learning (DRL) enhances the understanding of the effects of the randomness in the environment by letting agents learn the distribution of a random return, rather than its expected value as in standard…

Optimization and Control · Mathematics 2024-03-26 Zifan Wang , Yulong Gao , Siyi Wang , Michael M. Zavlanos , Alessandro Abate , Karl H. Johansson

The recursive and hierarchical structure of full rooted trees is applicable to represent statistical models in various areas, such as data compression, image processing, and machine learning. In most of these cases, the full rooted tree is…

Machine Learning · Statistics 2022-03-24 Yuta Nakahara , Shota Saito , Akira Kamatsuka , Toshiyasu Matsushima

We study the behavior of a point particle incident from the left on a slab of a randomly diluted triangular array of circular scatterers. Various scattering properties, such as the reflection and transmission probabilities and the…

Statistical Mechanics · Physics 2009-11-07 Hernan Larralde , Francois Leyvraz , Gustavo Martinez-Mekler , Raul Rechtman , Stefano Ruffo

We introduce a new model for conditional and continuous data morphing called TRansport Adversarial Network for Smooth InTerpolation (TRANSIT). We apply it to create a background data template for weakly-supervised searches at the LHC. The…

High Energy Physics - Phenomenology · Physics 2025-05-27 Ivan Oleksiyuk , Svyatoslav Voloshynovskiy , Tobias Golling

We propose Beam Tree Recursive Cell (BT-Cell) - a backpropagation-friendly framework to extend Recursive Neural Networks (RvNNs) with beam search for latent structure induction. We further extend this framework by proposing a relaxation of…

Machine Learning · Computer Science 2023-06-21 Jishnu Ray Chowdhury , Cornelia Caragea

We develop a simple computational model for cell boundary evolution in plastic deformation. We study the cell boundary size distribution and cell boundary misorientation distribution that experimentally have been found to have scaling forms…

Materials Science · Physics 2013-05-29 James P. Sethna , Valerie R. Coffman , Eugene Demler

Accurate forecasting of recovery rates (RR) is central to credit risk management and regulatory capital determination. In many loan portfolios, however, RR modeling is constrained by data scarcity arising from infrequent default events.…

Risk Management · Quantitative Finance 2026-04-24 Christopher Gerling , Hanqiu Peng , Ying Chen , Stefan Lessmann

T-cell receptors (TCRs) play a crucial role in the immune system by recognizing and binding to specific antigens presented by infected or cancerous cells. Understanding the sequence patterns of TCRs is essential for developing targeted…

Machine Learning · Computer Science 2024-08-05 Yicheng Lin , Dandan Zhang , Yun Liu

We propose inverse problems of crack propagation using the phase-field models. First, we study the crack propagation in an inhomogeneous media in which fracture toughness varies in space. Using the two phase-field models based on different…

Analysis of PDEs · Mathematics 2023-04-26 Yueyuan Gao , Natsuhiko Yoshinaga

Car following models have been widely applied and made remarkable achievements in traffic engineering. However, the traffic micro-simulation accuracy of car following models in a platoon level, especially during traffic oscillations, still…

Machine Learning · Computer Science 2019-10-28 Yangxin Lin , Ping Wang , Yang Zhou , Fan Ding , Chen Wang , Huachun Tan

Uncertainty calibration in pre-trained transformers is critical for their reliable deployment in risk-sensitive applications. Yet, most existing pre-trained transformers do not have a principled mechanism for uncertainty propagation through…