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Several disciplines, like the social sciences, epidemiology, sentiment analysis, or market research, are interested in knowing the distribution of the classes in a population rather than the individual labels of the members thereof.…

Machine Learning · Computer Science 2024-01-04 Alejandro Moreo , Pablo González , Juan José del Coz

We consider the problem of making nonparametric inference in a class of multi-dimensional diffusions in divergence form, from low-frequency data. Statistical analysis in this setting is notoriously challenging due to the intractability of…

Methodology · Statistics 2025-01-23 Matteo Giordano , Sven Wang

Infinitely many distinct trait values may arise in populations bearing quantitative traits, and modeling their population dynamics is thus a formidable task. While classical models assume fixed or infinite population size, models in which…

Populations and Evolution · Quantitative Biology 2025-05-08 Ananda Shikhara Bhat

We present a novel generative modeling method called diffusion normalizing flow based on stochastic differential equations (SDEs). The algorithm consists of two neural SDEs: a forward SDE that gradually adds noise to the data to transform…

Machine Learning · Computer Science 2021-10-15 Qinsheng Zhang , Yongxin Chen

We formulate a general, high-dimensional kinetic theory describing the internal state (such as gene expression or protein levels) of cells in a stochastically evolving population. The resolution of our kinetic theory also allows one to…

Populations and Evolution · Quantitative Biology 2026-05-12 Mingtao Xia , Tom Chou

We propose a general framework for solving statistical mechanics of systems with finite size. The approach extends the celebrated variational mean-field approaches using autoregressive neural networks, which support direct sampling and…

Statistical Mechanics · Physics 2019-06-10 Dian Wu , Lei Wang , Pan Zhang

Stochastic reaction networks are a fundamental model to describe interactions between species where random fluctuations are relevant. The master equation provides the evolution of the probability distribution across the discrete state space…

Molecular Networks · Quantitative Biology 2021-06-15 Tabea Waizmann , Luca Bortolussi , Andrea Vandin , Mirco Tribastone

Neural networks with a large number of parameters admit a mean-field description, which has recently served as a theoretical explanation for the favorable training properties of "overparameterized" models. In this regime, gradient descent…

Machine Learning · Statistics 2019-03-28 Grant Rotskoff , Samy Jelassi , Joan Bruna , Eric Vanden-Eijnden

Collective motion is an ubiquitous phenomenon in nature, inspiring engineers, physicists and mathematicians to develop mathematical models and bio-inspired designs. Collective motion at small to medium group sizes ($\sim$10-1000…

Machine Learning · Computer Science 2024-01-19 Utkarsh Pratiush , Arshed Nabeel , Vishwesha Guttal , Prathosh AP

A wide variety of biological phenomena can be modeled by the collective activity of a population of individual units. A common strategy for simulating such a system, the population density approach, is to take the macroscopic limit and…

Numerical Analysis · Mathematics 2021-06-15 Ningyuan Wang , Daniel B Forger

A general approach to provide approximate parameterizations of the "small" scales by the "large" ones, is developed for stochastic partial differential equations driven by linear multiplicative noise. This is accomplished via the concept of…

Analysis of PDEs · Mathematics 2013-10-16 Mickael D. Chekroun , Honghu Liu , Shouhong Wang

Density dependence is important in the ecology and evolution of microbial and cancer cells. Typically, we can only measure net growth rates, but the underlying density-dependent mechanisms that give rise to the observed dynamics can…

Populations and Evolution · Quantitative Biology 2025-06-04 Linh Huynh , Jacob G. Scott , Peter J. Thomas

Numerical resolution of high-dimensional nonlinear PDEs remains a huge challenge due to the curse of dimensionality. Starting from the weak formulation of the Lawson-Euler scheme, this paper proposes a stochastic particle method (SPM) by…

Numerical Analysis · Mathematics 2025-02-11 Zhengyang Lei , Sihong Shao , Yunfeng Xiong

The dominant modeling framework for understanding cortical computations are heuristic firing rate models. Despite their success, these models fall short to capture spike synchronization effects, to link to biophysical parameters and to…

Neurons and Cognition · Quantitative Biology 2019-09-24 Tilo Schwalger , Anton V. Chizhov

We investigate the dynamics of large-scale interacting neural populations, composed of conductance based, spiking model neurons with modifiable synaptic connection strengths, which are possibly also subjected to external noisy currents. The…

Neurons and Cognition · Quantitative Biology 2017-02-01 Daniel Gandolfo , Roger Rodriguez , Henry C. Tuckwell

Stochastic differential equations (SDEs) are established tools to model physical phenomena whose dynamics are affected by random noise. By estimating parameters of an SDE intrinsic randomness of a system around its drift can be identified…

Computation · Statistics 2012-05-03 Umberto Picchini , Susanne Ditlevsen

This work aims to estimate the drift and diffusion functions in stochastic differential equations (SDEs) driven by a particular class of L\'evy processes with finite jump intensity, using neural networks. We propose a framework that…

Machine Learning · Statistics 2025-07-10 Jose-Hermenegildo Ramirez-Gonzalez , Ying Sun

In this paper, we investigate the stochastic evolution equations (SEEs) driven by $\log$-Whittle-Mat$\acute{{\mathrm{e}}}$rn (W-M) random diffusion coefficient field and $Q$-Wiener multiplicative force noise. First, the well-posedness of…

Numerical Analysis · Mathematics 2022-07-05 X. Qi , M. Azaiez , C. Huang , C. Xu

Latent manifolds provide a compact characterization of neural population activity and of shared co-variability across brain areas. Nonetheless, existing statistical tools for extracting neural manifolds face limitations in terms of…

Neurons and Cognition · Quantitative Biology 2022-09-08 Edoardo Balzani , Jean Paul Noel , Pedro Herrero-Vidal , Dora E. Angelaki , Cristina Savin

Understanding the behavior of particles in a dispersed phase system via population balances holds fundamental importance in studies of particulate sciences across various fields. Particle behavior, however, is sophisticated as a single…

Computational Engineering, Finance, and Science · Computer Science 2026-02-16 Simon Ing Xun Tiong , Firnaaz Ahamed , Yong Kuen Ho