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We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in which we study a population with an oxygen-regulated…

Biological Physics · Physics 2017-09-01 Roberto de la Cruz , Pilar Guerrero , Fabian Spill , Tomás Alarcón

Generating function equation has been derived for the probability distribution of the number of nodes with $k \ge 0$ outgoing lines in randomly evolving special trees. The stochastic properties of end-nodes (k=0) have been analyzed, and it…

Statistical Mechanics · Physics 2007-05-23 L. Pal

Two mathematical models of macroevolution are studied. These models have population dynamics at the species level, and mutations and extinction of species are also included. The population dynamics are updated by difference equations with…

Populations and Evolution · Quantitative Biology 2014-04-16 Yohsuke Murase , Takashi Shimada , Nobuyasu Ito , Per Arne Rikvold

In biology and ecology, individuals or communities of individuals living in unpredictable environments often alternate between different evolutionary strategies to spread and reduce risks. Such behavior is commonly referred to as…

Populations and Evolution · Quantitative Biology 2015-03-11 Jorge Hidalgo , Simone Pigolotti , Miguel A. Munoz

Tipping points have been shown to be ubiquitous, both in models and empirically in a range of physical and biological systems. The question of how tipping points cascade through systems has been less well studied and is an important one. A…

Dynamical Systems · Mathematics 2020-11-19 Abhishek Mallela , Alan Hastings

We present an algorithm for the stochastic simulation of gene expression and heterogeneous population dynamics. The algorithm combines an exact method to simulate molecular-level fluctuations in single cells and a constant-number Monte…

Computational Physics · Physics 2016-08-24 Daniel A. Charlebois , Jukka Intosalmi , Dawn Fraser , Mads Kaern

We study contextual stochastic optimization problems, where we leverage rich auxiliary observations (e.g., product characteristics) to improve decision making with uncertain variables (e.g., demand). We show how to train forest decision…

Optimization and Control · Mathematics 2022-03-17 Nathan Kallus , Xiaojie Mao

In this paper, we address the question of comparison between populations of trees. We study an statistical test based on the distance between empirical mean trees, as an analog of the two sample z statistic for comparing two means. Despite…

Statistics Theory · Mathematics 2007-08-14 Ana Georgina Flesia , Ricardo Fraiman

Biological systems perform complex multi-step processes in a reproducible way despite underlying stochasticity. The standard explanation is micromanagement by molecular machinery that recognizes and corrects specific errors. Here we study…

Populations and Evolution · Quantitative Biology 2026-05-14 Riccardo Ravasio , Kabir Husain , Constantine G. Evans , Rob Phillips , Marco Ribezzi-Crivellari , Jack W. Szostak , Arvind Murugan

Understanding the evolution of binary traits, which affects the birth and survival of species and also the rate of molecular evolution, remains challenging. A typical example is the evolution of mating systems in plant species. In this…

Populations and Evolution · Quantitative Biology 2017-04-04 Daniah Tahir , Sylvain Glémin , Martin Lascoux , Ingemar Kaj

We introduce and analyse an individual-based evolutionary model, in which a population of genetically diverse organisms compete with each other for limited resources. Through theoretical analysis and stochastic simulations, we show that the…

Populations and Evolution · Quantitative Biology 2012-11-02 Tim Rogers , Alan J. McKane , Axel G. Rossberg

The matching problem plays a basic role in combinatorial optimization and in statistical mechanics. In its stochastic variants, optimization decisions have to be taken given only some probabilistic information about the instance. While the…

Statistical Mechanics · Physics 2013-09-03 Fabrizio Altarelli , Alfredo Braunstein , Abolfazl Ramezanpour , Riccardo Zecchina

Traditionally, frequency dependent evolutionary dynamics is described by deterministic replicator dynamics assuming implicitly infinite population sizes. Only recently have stochastic processes been introduced to study evolutionary dynamics…

Statistical Mechanics · Physics 2007-05-23 Arne Traulsen , Jens Christian Claussen , Christoph Hauert

During bouts of evolutionary diversification, such as adaptive radiations, the emerging species cluster around different locations in phenotype space, How such multimodal patterns in phenotype space can emerge from a single ancestral…

Populations and Evolution · Quantitative Biology 2007-11-19 Michael Doebeli , Hendrik J. Blok , Olof Leimar , Ulf Dieckmann

We propose a stochastic model for evolution through mutation and natural selection of a population that evolves on a $\bbT_d^+$ tree. We think of this model as a way of describing the evolution fitness landscape of a population. We obtain…

Probability · Mathematics 2021-04-13 Carolina Grejo , Fabio Lopes , Fábio Machado , Alejandro Roldán-Correa

We study the influence of the seed in random trees grown according to the uniform attachment model, also known as uniform random recursive trees. We show that different seeds lead to different distributions of limiting trees from a total…

Probability · Mathematics 2014-10-22 Sébastien Bubeck , Ronen Eldan , Elchanan Mossel , Miklós Z. Rácz

Understanding the causes and effects of spatial aggregation is one of the most fundamental problems in ecology. Aggregation is an emergent phenomenon arising from the interactions between the individuals of the population, able to sense…

Populations and Evolution · Quantitative Biology 2015-06-05 Juan A. Bonachela , Miguel A. Munoz , Simon A. Levin

This paper motivates the use of random-bridges -- stochastic processes conditioned to take target distributions at fixed timepoints -- in the realm of generative modelling. Herein, random-bridges can act as stochastic transports between two…

Machine Learning · Computer Science 2026-04-07 Stefano Goria , Levent A. Mengütürk , Murat C. Mengütürk , Berkan Sesen

This paper investigates the optimal harvesting strategy for a single species living in random environments whose growth is given by a regime-switching diffusion. Harvesting acts as a (stochastic) control on the size of the population. The…

Optimization and Control · Mathematics 2016-08-02 Qingshuo Song , Richard Stockbridge , Chao Zhu

Horizontal gene transfer consists in exchanging genetic materials between microorganisms during their lives. This is a major mechanism of bacterial evolution and is believed to be of main importance in antibiotics resistance. We consider a…

Probability · Mathematics 2019-12-18 Nicolas Champagnat , Sylvie Méléard , Viet Chi Tran
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