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We propose a tomographic method to reconstruct the optical properties of a highly-scattering medium from incoherent acousto-optic measurements. The method is based on the solution to an inverse problem for the diffusion equation and makes…

Optics · Physics 2015-05-14 Guillaume Bal , John C Schotland

In this work, an inverse problem on the determination of multiple coefficients arising from the time-domain diffuse optical tomography with fluorescence (DOT-FDOT) is investigated. We simultaneously recover the distribution of background…

Numerical Analysis · Mathematics 2023-11-23 Zhiyuan Li , Chunlong Sun

We consider the inverse problem of recovering the optical properties of a highly-scattering medium from acousto-optic measurements. Using such measurements, we show that the scattering and absorption coefficients of the radiative transport…

Analysis of PDEs · Mathematics 2016-09-27 Francis J Chung , John C Schotland

Forward-viewing endoscopic optical coherence tomography (OCT) provides 3D imaging in vivo, and can be combined with widefield fluorescence imaging by use of a double-clad fiber. However, it is technically challenging to build a…

Diffuse optical tomography (DOT) utilises near-infrared light for imaging spatially distributed optical parameters, typically the absorption and scattering coefficients. The image reconstruction problem of DOT is an ill-posed inverse…

Computational Physics · Physics 2021-12-15 Meghdoot Mozumder , Andreas Hauptmann , Ilkka Nissilä , Simon R. Arridge , Tanja Tarvainen

Optical coherence tomography (OCT) is a label-free, non-invasive 3D imaging tool widely used in both biological research and clinical diagnosis. Current OCT modalities can only visualize specimen tomography without chemical information.…

In this paper, we propose a framework that incorporates experts diagnostics and insights into the analysis of Optical Coherence Tomography (OCT) using multi-modal learning. To demonstrate the effectiveness of this approach, we create a…

Image and Video Processing · Electrical Eng. & Systems 2022-03-22 Y. Logan , K. Kokilepersaud , G. Kwon , G. AlRegib , C. Wykoff , H. Yu

Optical Coherence Tomography (OCT) is the primary imaging modality for detecting pathological biomarkers associated to retinal diseases such as Age-Related Macular Degeneration. In practice, clinical diagnosis and treatment strategies are…

Computer Vision and Pattern Recognition · Computer Science 2019-07-17 Thomas Kurmann , Pablo Márquez-Neila , Siqing Yu , Marion Munk , Sebastian Wolf , Raphael Sznitman

Nowadays, the field computed tomography (CT) encompasses a large variety of settings, ranging from nanoscale to meter-sized objects imaged by different kinds of radiation in various acquisition modes. This experimental diversity challenges…

Numerical Analysis · Mathematics 2019-01-11 Simon Maretzke

We propose a strategy for quantitative photoacoustic mapping of chromophore concentrations that can be performed purely experimentally. We exploit the possibility of acousto-optic modulation using focused ultrasound, and the principle that…

Optics · Physics 2012-07-23 Khalid Daoudi , Wiendelt Steenbergen

Currently, diagnosis of skin diseases is based primarily on visual pattern recognition skills and expertise of the physician observing the lesion. Even though dermatologists are trained to recognize patterns of morphology, it is still a…

Photoacoustic tomography (PAT) enables non-invasive cross-sectional imaging of biological tissues, but it fails to map the spatial variation of speed-of-sound (SOS) within tissues. While SOS is intimately linked to density and elastic…

Medical Physics · Physics 2024-08-27 Yang Wang , Danni Wang , Liting Zhong , Yi Zhou , Qing Wang , Wufan Chen , Li Qi

Optical diffraction tomography (ODT) is a tomographic technique that can be used to measure the three-dimensional (3D) refractive index distribution within living cells without the requirement of any marker. In principle, ODT can be…

Quantitative Methods · Quantitative Biology 2018-01-03 Paul Müller , Mirjam Schürmann , Chii J. Chan , Jochen Guck

For optical coherence tomography angiography (OCTA) images, a limited scanning rate leads to a trade-off between field-of-view (FOV) and imaging resolution. Although larger FOV images may reveal more parafoveal vascular lesions, their…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Weiwen Zhang , Dawei Yang , Haoxuan Che , An Ran Ran , Carol Y. Cheung , Hao Chen

We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of the penetration depth and imaging quality. OCA reduces…

We study the direct and an inverse source problem for the radiative transfer equation arising in optical molecular imaging. We show that for generic absorption and scattering coefficients, the direct problem is well-posed and the inverse…

Analysis of PDEs · Mathematics 2008-03-31 Plamen Stefanov , Gunther Uhlmann

Mid-infrared light scatters much less than shorter wavelengths, allowing greatly enhanced penetration depths for optical imaging techniques such as optical coherence tomography (OCT). However, both detection and broadband sources in the…

Quantum information technologies harness the intrinsic nature of quantum theory to beat the limitations of the classical methods for information processing and communication. Recently, the application of quantum features to metrology has…

Acousto-optic tomography (AOT) enables optical-contrast imaging deep inside scattering samples via localized ultrasound modulation of scattered light. However, the resolution of AOT is inherently limited by the ultrasound focus size,…

Optics · Physics 2018-12-12 Daniel Doktofsky , Moriya Rosenfeld , Ori Katz

The inversion of linear systems is a fundamental step in many inverse problems. Computational challenges exist when trying to invert large linear systems, where limited computing resources mean that only part of the system can be kept in…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-09-05 Yushan Gao , Thomas Blumensath