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Optical coherence tomography angiography (OCTA) has been established as a powerful tool for investigating vascular diseases and is expected to become a standard of care technology. However, its widespread clinical usage is hindered by…

Medical Physics · Physics 2021-09-10 Si Chen , Kan Lin , Linbo Liu

We consider the inverse problem of reconstructing the scattering coefficient of a simple radiative transport equation (RTE) used to model light propagation inside a scattering medium. To do so, we extract information from the second term in…

Analysis of PDEs · Mathematics 2025-08-07 Francis Chung , Faith Hensley

We consider the reconstruction of the diffusion and absorption coefficients of the diffusion equation from the internal information of the solution obtained from the first step of the inverse photoacoustic tomography (PAT). In practice, the…

Analysis of PDEs · Mathematics 2021-09-22 Faouzi Triki , Qi Xue

Optical coherence tomography angiography (OCTA) is a novel and clinically promising imaging modality to image retinal and sub-retinal vasculature. Based on repeated optical coherence tomography (OCT) scans, intensity changes are observed…

Image and Video Processing · Electrical Eng. & Systems 2020-10-30 Lennart Husvogt , Stefan B. Ploner , Siyu Chen , Daniel Stromer , Julia Schottenhamml , A. Yasin Alibhai , Eric Moult , Nadia K. Waheed , James G. Fujimoto , Andreas Maier

Optoacoustic (OA) imaging is based on excitation of biological tissues with nanosecond-duration laser pulses followed by subsequent detection of ultrasound waves generated via light-absorption-mediated thermoelastic expansion. OA imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-05-04 Firat Ozdemir , Berkan Lafci , Xosé Luís Deán-Ben , Daniel Razansky , Fernando Perez-Cruz

Photoacoustic tomography (PAT) is a newly developed medical imaging modality, which combines the advantages of pure optical imaging and ultrasound imaging, owning both high optical contrast and deep penetration depth. Very recently, PAT is…

Medical Physics · Physics 2021-09-21 Tengbo Lyu , Jiadong Zhang , Zijian Gao , Changchun Yang , Feng Gao , Fei Gao

Nonlinear optics is essential for many recent photonic technologies. Here, we introduce a novel multi-scale approach to simulate the nonlinear optical response of molecular nanomaterials combining ab initio quantum-chemical and classical…

Objective:Optoacoustic (photoacoustic) tomography is aimed at reconstructing maps of the initial pressure rise induced by the absorption of light pulses in tissue. In practice, due to inaccurate assumptions in the forward model, noise and…

Medical Physics · Physics 2019-01-21 Jaya Prakash , Subhamoy Mandal , Daniel Razansky , Vasilis Ntziachristos

Quantum sensing exploits quantum phenomena to enhance the detection and estimation of classical parameters of physical systems and biological entities, particularly so as to overcome the inefficiencies of its classical counterparts. A…

Iterative model-based image reconstruction in photoacoustic tomography (PAT) enables principled incorporation of detector physics, object-related priors, and complex acquisition strategies. However, for three-dimensional (3D) imaging…

We consider the problem of optical tomographic imaging in the mesoscopic regime where the photon mean free path is of order of the system size. Within the accuracy of the single-scattering approximation to the radiative transport equation,…

Medical Physics · Physics 2009-04-29 Lucia Florescu , John C. Schotland , Vadim A. Markel

The development of accurate and efficient image reconstruction algorithms is a central aspect of quantitative photoacoustic tomography (QPAT). In this paper, we address this issues for multi-source QPAT using the radiative transfer equation…

Numerical Analysis · Mathematics 2018-03-29 Simon Rabanser , Lukas Neumann , Markus Haltmeier

Optical coherence tomography has become an important imaging technology in cardiology and ophthalmology, with other applications under investigations. Major advances in optical coherence tomography (OCT) imaging are likely to occur through…

Quantum Physics · Physics 2014-02-10 Mark E. Brezinski

Optical coherence tomography (OCT) can perform non-invasive high-resolution three-dimensional (3D) imaging and has been widely used in biomedical fields, while it is inevitably affected by coherence speckle noise which degrades OCT imaging…

Optics · Physics 2025-06-30 Renxiong Wu , Fei Zheng , Meixuan Li , Shaoyan Huang , Xin Ge , Linbo Liu , Yong Liu , Guangming Ni

Optical projection tomography (OPT) is a powerful tool for biomedical studies. It achieves 3D visualization of mesoscopic biological samples with high spatial resolution using conventional tomographic-reconstruction algorithms. However,…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Yan Liu , Jonathan Dong , Thanh-An Pham , Francois Marelli , Michael Unser

A two-step shape reconstruction method for diffuse optical tomography (DOT) is presented which uses adjoint fields and level sets. The propagation of near-infrared photons in tissue is modeled by the time-dependent linear transport…

Numerical Analysis · Mathematics 2025-10-20 Oliver Dorn

In photoacoustic tomography (PAT), the computation of the initial pressure distribution within an object from its time-dependent boundary measurements over time is considered. This problem can be approached from two well-established points…

Numerical Analysis · Mathematics 2025-07-04 Jaakko Kultima , Ronny Ramlau , Teemu Sahlström , Tanja Tarvainen

Photoacoustic computed tomography (PACT) is a hybrid imaging modality, which combines the high optical contrast of pure optical imaging and the high penetration depth of ultrasound imaging. However, photoacoustic image dataset with good…

Medical Physics · Physics 2022-05-24 Tengbo Lyu , Changchun Yang , Jiadong Zhang , Shanshan Guo , Feng Gao , Fei Gao

We discuss a quantum mechanical indirect measurement method to recover a position dependent Hamilton matrix from time evolution of coherent quantum mechanical states through an object. A mathematical formulation of this inverse problem…

Mathematical Physics · Physics 2016-06-21 Joonas Ilmavirta

In this article, we revisit iterative methods for solving the inverse problem of photoacoustic tomography in free space. Recently, there have been interesting developments on explicit formulations of the adjoint operator, demonstrating that…

Analysis of PDEs · Mathematics 2017-05-16 Markus Haltmeier , Linh V. Nguyen