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In the 1990s, Richard Lewontin referred to what appeared to be the twilight of determinism in biology. He pointed out that DNA determines only a little part of life phenomena, which are very complex. In fact, organisms determine the…

History and Philosophy of Physics · Physics 2015-10-20 Amihud Gilead

The Universe contains everything that exists, including life. And all that exists, including life, obeys universal physical laws. Do those laws then give adequate foundations for a complete explanation of biological phenomena? We discuss…

History and Philosophy of Physics · Physics 2022-04-29 Marina Cortês , Stuart A. Kauffman , Andrew R. Liddle , Lee Smolin

Shape is one of the important characteristics for the structures observed in living organisms. Whereas biologists have proposed models where the shape is controlled on a molecular level [1], physicists, following Turing [2] and d'Arcy…

Tissues and Organs · Quantitative Biology 2010-10-11 Etienne Couturier , Sylvain Courrech du Pont , Stephane Douady

We outline a phenomenological theory of evolution and origin of life by combining the formalism of classical thermodynamics with a statistical description of learning. The maximum entropy principle constrained by the requirement for…

Populations and Evolution · Quantitative Biology 2022-10-12 Vitaly Vanchurin , Yuri I. Wolf , Eugene V. Koonin , Mikhail I. Katsnelson

Life mechanics, an emerging field, focuses on the self-organizing forces and motions within living systems. This study introduces the novel concept of active force, generated by mind-body interactions, as an essential element in…

Biological Physics · Physics 2023-09-21 Rong Li , Weicheng Cui

Epigenetic Tracking is a mathematical model of biological cells, originally conceived to study embryonic development. Computer simulations proved the capacity of the model to generate complex 3-dimensional cellular structures, and the…

Cell Behavior · Quantitative Biology 2015-07-07 Alessandro Fontana

When a large number of similar entities interact among each other and with their environment at a low scale, unexpected outcomes at higher spatio-temporal scales might spontaneously arise. This nontrivial phenomenon, known as emergence,…

Physics and Society · Physics 2022-05-25 Oriol Artime , Manlio De Domenico

Modern developments in nonequilibrium thermodynamics have significant implications for the origins of life. The reasons for this are closely related to a generalized version of the second law of thermodynamics recently found for entropy…

General Physics · Physics 2022-04-04 Gerald E. Marsh

Many biological processes can be thought of as the result of an underlying dynamics in which the system repeatedly undergoes distinct and abortive trajectories with the dynamical process only ending when some specific process, purpose,…

Biological Physics · Physics 2025-06-05 Jane Kondev , Marc Kirschner , Hernan G. Garcia , Gabriel L. Salmon , Rob Phillips

This paper explores the idea that information is an essential and distinctive feature of living systems. Unlike non-living systems, living systems actively acquire, process, and use information about their environments to respond to…

The importance of molecular-scale forces in sculpting biological form and function has been acknowledged for more than a century. Accounting for forces in biology is a problem that lies at the intersection of soft condensed matter physics,…

Soft Condensed Matter · Physics 2025-12-10 K. Vijay Kumar , Mandar M. Inamdar , Pramod A. Pullarkat , Gautam I. Menon

Impedance Spectroscopy resolves electrical properties into uncorrelated variables, as a function of frequency, with exquisite resolution. Separation is robust and most useful when the system is linear. Impedance spectroscopy combined with…

Quantitative Methods · Quantitative Biology 2015-11-05 Robert Eisenberg

The recent discovery of a lateral organization in cell membranes due to small structures called 'rafts' has motivated a lot of biological and physico-chemical studies. A new experiment on a model system has shown a spectacular budding…

Subcellular Processes · Quantitative Biology 2009-11-10 Jean-Marc Allain , Martine Ben Amar

We survey some of the philosophical challenges and pitfalls within origins research. Several of these challenges exhibit circularities, paradoxes, or anthropic biases. We present origins approaches in terms of three broad categories:…

Popular Physics · Physics 2023-03-15 Stuart Bartlett , Michael L Wong

Several aspects of mathematical astrobiology are discussed. It is argued that around the time of the origin of life the handedness of biomolecules must have established itself through an instability. Possible pathways of producing a certain…

Biomolecules · Quantitative Biology 2011-07-05 Axel Brandenburg

A fundamental issue discussed in evolutionary biology is the transition from unicellular to multicellular organisms. Here we develop non-robust models provided in [1] and attempt to get robust models investigated how differentiation of…

Populations and Evolution · Quantitative Biology 2015-12-15 Denis Tverskoy

The decisive role of Embryology in understanding the evolution of animal forms is founded and deeply rooted in the history of science. It is recognized that the emergence of multicellularity would not have been possible without the…

Tissues and Organs · Quantitative Biology 2026-03-20 Jaime Cofre , Kay Saalfeld

The sequence of nucleotide bases occurring in an organism's DNA is often regarded as a codescript for its construction. However, information in a DNA sequence can only be regarded as a codescript relative to an operational biochemical…

Other Quantitative Biology · Quantitative Biology 2013-08-12 Peter R. Wills

Life is a discrete, stochastic phenomena : for a biological organism, the time of the two most important events of its life (reproduction and death) is random and these events change the number of individuals of the species by single units.…

Biological Physics · Physics 2013-06-20 Bahram Houchmandzadeh

Many problems in evolutionary theory are cast in dyadic terms, such as the polar oppositions of organism and environment. We argue that a triadic conceptual structure offers an alternative perspective under which the information generating…

Adaptation and Self-Organizing Systems · Physics 2010-06-30 Carsten Herrmann-Pillath , Stanley N. Salthe