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Cochlear implants (CI) significantly improve spoken language in children with severe-to-profound sensorineural hearing loss (SNHL), yet outcomes remain more variable than in children with normal hearing. This variability cannot be reliably…

Computation and Language · Computer Science 2025-11-17 Yanlin Wang , Di Yuan , Shani Dettman , Dawn Choo , Emily Shimeng Xu , Denise Thomas , Maura E Ryan , Patrick C M Wong , Nancy M Young

Alzheimer's disease and related dementias(ADRD) affect nearly five million older adults in the United States, yet more than half remain undiagnosed. Speech-based natural language processing(NLP) offers a scalable approach for detecting…

Unveiling pathological brain changes associated with Alzheimer's disease (AD) is a challenging task especially that people do not show symptoms of dementia until it is late. Over the past years, neuroimaging techniques paved the way for…

Quantitative Methods · Quantitative Biology 2018-08-07 Mayssa Soussia , Islem Rekik

Alzheimer's disease is a neurogenerative disease that alters memories, cognitive functions leading to death. Early diagnosis of the disease, by detection of the preliminary stage, called Mild Cognitive Impairment (MCI), remains a…

Image and Video Processing · Electrical Eng. & Systems 2020-12-03 Achraf Ben Miled , Taoufik Yeferny , Amira ben Rabeh

Pre-trained multilingual language models such as mBERT have shown immense gains for several natural language processing (NLP) tasks, especially in the zero-shot cross-lingual setting. Most, if not all, of these pre-trained models rely on…

Computation and Language · Computer Science 2020-10-26 Aditi Chaudhary , Karthik Raman , Krishna Srinivasan , Jiecao Chen

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's…

Mild Traumatic Brain Injury (TBI) detection presents significant challenges due to the subtle and often ambiguous presentation of symptoms in medical imaging, making accurate diagnosis a complex task. To address these challenges, we propose…

Performance monitoring of machine learning (ML)-based risk prediction models in healthcare is complicated by the issue of confounding medical interventions (CMI): when an algorithm predicts a patient to be at high risk for an adverse event,…

Machine Learning · Statistics 2023-04-17 Jean Feng , Alexej Gossmann , Gene Pennello , Nicholas Petrick , Berkman Sahiner , Romain Pirracchio

Subjective cognitive decline (SCD) is a preclinical stage of Alzheimer's disease (AD) which occurs even before mild cognitive impairment (MCI). Progressive SCD will convert to MCI with the potential of further evolving to AD. Therefore,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Hao Guan , Ling Yue , Pew-Thian Yap , Shifu Xiao , Andrea Bozoki , Mingxia Liu

In 2019, The Centers for Medicare and Medicaid Services (CMS) launched an Artificial Intelligence (AI) Health Outcomes Challenge seeking solutions to predict risk in value-based care for incorporation into CMS Innovation Center payment and…

Machine Learning · Computer Science 2021-05-21 Chuhong Lahlou , Ancil Crayton , Caroline Trier , Evan Willett

Background: Mild cognitive impairment (MCI) is often considered a precursor to Alzheimer's disease (AD) due to the high rate of progression from MCI to AD. Sensitive neural biomarkers may provide a tool for an accurate MCI diagnosis,…

Neurons and Cognition · Quantitative Biology 2022-11-02 Adi Wijaya , Noor Akhmad Setiawan , Asma Hayati Ahmad , Rahimah Zakaria , Zahiruddin Othman

Predicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in Alzheimer's disease (AD). Traditional survival models often…

Applications · Statistics 2025-03-24 Dhrubajyoti Ghosh , Samhita Pal , Michael Lutz , Sheng Luo

Alzheimer's Disease (AD) is a progressive neurodegenerative disease. Amnestic mild cognitive impairment (MCI) is a common first symptom before the conversion to clinical impairment where the individual becomes unable to perform activities…

Computer Vision and Pattern Recognition · Computer Science 2017-10-16 Donghuan Lu , Karteek Popuri , Weiguang Ding , Rakesh Balachandar , Mirza Faisal Beg

Alzheimer's disease has an increasing prevalence in the population world-wide, yet current diagnostic methods based on recommended biomarkers are only available in specialized clinics. Due to these circumstances, Alzheimer's disease is…

Quantitative Methods · Quantitative Biology 2023-12-07 Sophia Krix , Ella Wilczynski , Neus Falgàs , Raquel Sánchez-Valle , Eti Yoles , Uri Nevo , Kuti Baruch , Holger Fröhlich

Brain-computer interface (BCI) provides a direct communication pathway between human brain and external devices. Before a new subject could use BCI, a calibration procedure is usually required. Because the inter- and intra-subject variances…

Signal Processing · Electrical Eng. & Systems 2022-09-09 Jingcong Li , Fei Wang , Haiyun Huang , Feifei Qi , Jiahui Pan

Automatic assessment of cognitive impairment from spontaneous speech offers a promising, non-invasive avenue for early cognitive screening. However, current approaches often lack generalizability when deployed across different languages and…

Artificial Intelligence · Computer Science 2025-10-20 Rui Feng , Zhiyao Luo , Wei Wang , Yuting Song , Yong Liu , Tingting Zhu , Jianqing Li , Xingyao Wang

Mild cognitive impairment (MCI) leading to dementia results in a constellation of psychiatric disorders including depression, mood disorders, schizophrenia and others. With increasing age, mild cognitive impairment leads to increased…

Neurons and Cognition · Quantitative Biology 2023-08-10 Sheng Mai

Brain structural MRI has been widely used to assess the future progression of cognitive impairment (CI). Previous learning-based studies usually suffer from the issue of small-sized labeled training data, while there exist a huge amount of…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Lintao Zhang , Jinjian Wu , Lihong Wang , Li Wang , David C. Steffens , Shijun Qiu , Guy G. Potter , Mingxia Liu

Dementia is a neurodegenerative disorder that causes cognitive decline and affects more than 50 million people worldwide. Dementia is under-diagnosed by healthcare professionals - only one in four people who suffer from dementia are…

Transformer-based language models (LMs) continue to achieve state-of-the-art performance on natural language processing (NLP) benchmarks, including tasks designed to mimic human-inspired "commonsense" competencies. To better understand the…

Computation and Language · Computer Science 2022-05-13 Antonio Laverghetta , Animesh Nighojkar , Jamshidbek Mirzakhalov , John Licato