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The Poland-Scheraga model for DNA denaturation, besides playing a central role in applications, has been widely studied in the physical and mathematical literature over the past decades. More recently a natural generalization has been…

Probability · Mathematics 2017-03-31 Quentin Berger , Giambattista Giacomin , Maha Khatib

Poland-Scheraga models were introduced to describe the DNA denaturation transition. We give a rigorous and refined discussion of a family of these models. We derive possible scaling functions in the neighborhood of the phase transition…

Statistical Mechanics · Physics 2008-08-28 C. Richard , A. J. Guttmann

We investigate the generalized Poland-Scheraga model, which is used in the bio-physical literature to model the DNA denaturation transition, in the case where the two strands are allowed to be non-complementary (and to have different…

Probability · Mathematics 2018-07-31 Quentin Berger , Giambattista Giacomin , Maha Khatib

The Poland-Scheraga model is a celebrated model for the denaturation transition of DNA, which has been widely used in the bio-physical literature to study, and investigated by mathematicians. In the original model, only opposite bases of…

Probability · Mathematics 2020-11-05 Alexandre Legrand

The Poland--Scheraga model, introduced in the 1970's, is a reference model to describe the denaturation transition of DNA. More recently, it has been generalized in order to allow for asymmetry in the strands lengths and in the formation of…

Probability · Mathematics 2024-06-18 Quentin Berger , Alexandre Legrand

We compare results of previous simulations of a simple model of DNA denaturation to the predictions of the Poland-Scheraga model. Concentrating on the critical region of the latter model we calculate both thermodynamic quantities and the…

Statistical Mechanics · Physics 2007-05-23 Lothar Schäfer

The Poland-Scheraga (PS) model for the helix-coil transition of DNA considers the statistical mechanics of the binding (or hybridization) of two complementary strands of DNA of equal length, with the restriction that only bases with the…

Biomolecules · Quantitative Biology 2007-05-23 Thomas Garel , Henri Orland

The denaturation dynamics of a long double-stranded DNA is studied by means of a model of the Poland-Scheraga type. We note that the linking of the two strands is a locally conserved quantity, hence we introduce local updates that respect…

Statistical Mechanics · Physics 2009-01-28 Marco Baiesi , Roberto Livi

Using a field theory equivalent to a lattice version of the Poland-Scheraga (PS) model, the phase diagram for a long DNA molecule is derived in closed form. A one-loop renormalization group calculation for the generalized PS model with…

Soft Condensed Matter · Physics 2026-04-01 Richard Dengler

The Poland-Scheraga (PS) model for the helix-coil transition of DNA considers the statistical mechanics of the thermally induced binding of two complementary strands of DNA. In this paper, we show how to modify the PS model when a torque is…

Biomolecules · Quantitative Biology 2007-05-23 Thomas Garel , Henri Orland , Edouard Yeramian

We numerically study the binary disordered Poland-Scheraga model of DNA denaturation, in the regime where the pure model displays a first order transition (loop exponent $c=2.15>2$). We use a Fixman-Freire scheme for the entropy of loops…

Disordered Systems and Neural Networks · Physics 2007-05-23 Thomas Garel , Cecile Monthus

The denaturation transition which takes place in circular DNA is analyzed by extending the Poland-Scheraga model to include the winding degrees of freedom. We consider the case of a homopolymer whereby the winding number of the double…

Statistical Mechanics · Physics 2011-11-22 Amir Bar , Alkan Kabakçıoğlu , David Mukamel

We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force. We demonstrate the existence of a force-induced DNA denaturation transition and obtain the temperature-force phase…

Soft Condensed Matter · Physics 2009-11-13 Andreas Hanke , Martha G. Ochoa , Ralf Metzler

In the framework of the Poland Scheraga model of DNA denaturation, we derive a recursion relation for the partition function of double stranded DNA, allowing for mismatches between the two strands. This relation is studied numerically using…

Soft Condensed Matter · Physics 2007-05-23 T. Garel , H. Orland

The denaturation transition of circular DNA is studied within a Poland-Scheraga type approach, generalized to account for the fact that the total linking number (LK), which measures the number of windings of one strand around the other, is…

Statistical Mechanics · Physics 2015-06-05 Amir Bar , Alkan Kabakçıoğlu , David Mukamel

We study numerically the effect of sequence heterogeneity on the thermodynamic properties of a Poland-Scheraga model for DNA denaturation taking into account self-avoidance, i.e. with exponent c_p=2.15 for the loop length probability…

Disordered Systems and Neural Networks · Physics 2016-05-06 Barbara Coluzzi , Edouard Yeramian

We give an overview of the state of the art of the analysis of disordered models of pinning on a defect line. This class of models includes a number of well known and much studied systems (like polymer pinning on a defect line, wetting of…

Mathematical Physics · Physics 2008-07-29 Giambattista Giacomin

We perform an extensive numerical study of the disordered Poland-Scheraga (PS) model for DNA denaturation in which self-avoidance is completely taken into account. In complement to our previous work, we focus here on the finite size scaling…

Soft Condensed Matter · Physics 2016-05-05 Barbara Coluzzi , Edouard Yeramian

We generalize the Poland-Scheraga (PS) model to the case of a circular DNA, taking into account the twisting of the two strains around each other. Guided by recent single-molecule experiments on DNA strands, we assume that the torsional…

Soft Condensed Matter · Physics 2009-06-04 A. Kabakcioglu , E. Orlandini , D. Mukamel

We present a precise equivalence of the Lifson-Poland-Scheraga model with wetting models. Making use of a representation of the former model in terms of random matrices, we obtain, in the limit of weak disorder, a mean--field approximation,…

Statistical Mechanics · Physics 2015-06-05 Hervé Kunz , Roberto Livi
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