Denaturation transition of stretched DNA
Soft Condensed Matter
2009-11-13 v2 Statistical Mechanics
Biomolecules
Abstract
We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force. We demonstrate the existence of a force-induced DNA denaturation transition and obtain the temperature-force phase diagram. The transition is determined by the loop exponent for which we find the new value such that the transition is second order with in . We show that a finite stretching force destabilizes DNA, corresponding to a lower melting temperature , in agreement with single-molecule DNA stretching experiments.
Keywords
Cite
@article{arxiv.0709.2958,
title = {Denaturation transition of stretched DNA},
author = {Andreas Hanke and Martha G. Ochoa and Ralf Metzler},
journal= {arXiv preprint arXiv:0709.2958},
year = {2009}
}
Comments
5 pages, 3 figures