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The clinical need for ultra-sensitive molecular analysis has motivated the development of several endpoint assay technologies capable of single molecule readout. These endpoint assays are now primarily limited by the affinity and…

Biological Physics · Physics 2019-05-22 Derin Sevenler , Jacob Trueb , M. Selim Ünlü

Thermal expansion, or dilation, is closely related to the specific heat, and provides useful information regarding material properties. The accurate measurement of dilation in confined spaces coupled with other limiting experimental…

Instrumentation and Detectors · Physics 2010-01-15 J. -H. Park , D. Graf , T. P. Murphy , G. M. Schmiedeshoff , S. W. Tozer

From infancy to adulthood, human growth is anisotropic, much more along the proximal-distal axis (height) than along the medial-lateral axis (width), particularly at extremities. Detecting and modeling the rate of anisotropy in fingerprint…

Applications · Statistics 2018-01-22 Karla Markert , Karolin Krehl , Carsten Gottschlich , Stephan F. Huckemann

We realize a scanning probe microscope using single trapped $^{87}$Rb atoms to measure optical fields with subwavelength spatial resolution. Our microscope operates by detecting fluorescence from a single atom driven by near-resonant light…

Atomic Physics · Physics 2022-03-02 Emma Deist , Justin A. Gerber , Yue-Hui Lu , Johannes Zeiher , Dan M. Stamper-Kurn

We present an advanced scanning probe microscopy system enhanced with artificial intelligence (AI-SPM) designed for self-driving atomic-scale measurements. This system expertly identifies and manipulates atomic positions with high…

Computational Physics · Physics 2024-04-18 Zhuo Diao , Keiichi Ueda , Linfeng Hou , Fengxuan Li , Hayato Yamashita , Masayuki Abe

Atomic force microscope (AFM) users often calibrate the spring constants of cantilevers using functionality built into individual instruments. This is performed without reference to a global standard, which hinders robust comparison of…

We experimentally investigated the contrast mechanism of infrared photoinduced force microscopy (PiFM) for recording vibrational resonances. Extensive experiments have demonstrated that spectroscopic contrast in PiFM is mediated by…

Instrumentation and Detectors · Physics 2020-12-02 Mohammad A. Almajhadi , Syed Mohammad Ashab Uddin , H. Kumar Wickramasinghe

High-speed atomic force microscopy (HS-AFM) is an indispensable technique in the biological field owing to its excellent imaging capability for the real-time observation of biomolecules with high spatial resolution. Furthermore, recent…

A MEMS based tribometer has been developed that can be read out with nanometer and nano-Newton resolution, approaching the resolution and sensitivity of a friction force microscope (FFM). It can be used to study friction of MEMS device…

The negatively-charged nitrogen-vacancy center (NV) in diamond forms a versatile system for quantum sensing applications. Combining the advantageous properties of this atomic-sized defect with scanning probe techniques such as atomic force…

Mesoscale and Nanoscale Physics · Physics 2018-12-26 Philipp Fuchs , Michel Challier , Elke Neu

Atomic force microscopy using a magnetic tip is a promising tool for investigating conductivity on the nano-scale. By the oscillating magnetic tip eddy currents are induced in the conducting parts of the sample which can be detected in the…

Atomic Physics · Physics 2009-11-13 Tino Roll , Marion Meier , Ulrich Fischer , Marika Schleberger

The description of hydrodynamic interactions between a particle and the surrounding liquid, down to the nanometer scale, is of primary importance since confined liquids are ubiquitous in many natural and technological situations. In this…

A new method is introduced for calibrating lateral force as measured by an atomic force microscope (AFM), making use of both an interferometric detector and an optical beam detector on the same instrument. The method may be implemented…

Mesoscale and Nanoscale Physics · Physics 2025-03-25 Joel Lefever , Aleksander Labuda , Roger Proksch

Atomistic simulations are used to test the equations of continuum contact mechanics in nanometer scale contacts. Nominally spherical tips, made by bending crystals or cutting crystalline or amorphous solids, are pressed into a flat, elastic…

Materials Science · Physics 2009-11-11 Binquan Luan , Mark O. Robbins

Atomic Force Microscopy (AFM) is a suitable tool to perform tribological characterization of materials down to the nanometer scale. An important aspect in nanofriction measurements of corrugated samples is the local tilt of the surface,…

Condensed Matter · Physics 2017-06-22 A. Podesta' , G. Fantoni , P. Milani

Heat transport in low-dimensional solids can significantly differ from their bulk counterpart due to various size-related effects. This offers rich heat transport phenomena to emerge. However, finding an appropriate thermometry method for…

Mesoscale and Nanoscale Physics · Physics 2025-06-12 T. Serkan Kasırga , Berke Köker

A recent advance in improving the spatial resolution of magnetic force microscopy (MFM) uses as sensor tips carbon nanotubes grown at the apex of conventional silicon cantilever pyramids and coated with a thin ferromagnetic layer. Magnetic…

Mesoscale and Nanoscale Physics · Physics 2009-11-13 John R. Kirtley , Zhifeng Deng , Lan Luan , Erhan Yenilmez , Hongjie Dai , Kathryn A. Moler

Magnetic Resonance Imaging (MRI) is universally acknowledged as an excellent tool to extract detailed spatial information with minimally invasive measurements. Efforts toward ultra-low-field (ULF) MRI are made to simplify the scanners and…

Applied Physics · Physics 2019-10-28 Giuseppe Bevilacqua , Valerio Biancalana , Yordanka Dancheva , Antonio Vigilante

The paper describes the peculiarities of acquirement and interpretation of images of current distribution through the sample surface when operating in I-AFM mode. It shows that I-AFM and SCM modes can be successfully used only for small…

Instrumentation and Detectors · Physics 2020-12-15 Olga V. Sviridova

In scanning gate microscopy, where the tip of a scanning force microscope is used as a movable gate to study electronic transport in nanostructures, the shape and magnitude of the tip-induced potential are important for the resolution and…

Mesoscale and Nanoscale Physics · Physics 2009-11-13 A. E. Gildemeister , T. Ihn , M. Sigrist , K. Ensslin , D. C. Driscoll , A. C. Gossard