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In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a…

Neurons and Cognition · Quantitative Biology 2019-05-27 Raphaël Sivera , Hervé Delingette , Marco Lorenzi , Xavier Pennec , Nicholas Ayache

The field of neuroimaging has truly become data rich, and novel analytical methods capable of gleaning meaningful information from large stores of imaging data are in high demand. Those methods that might also be applicable on the level of…

Dropout represents a typical issue to be addressed when dealing with longitudinal studies. If the mechanism leading to missing information is non-ignorable, inference based on the observed data only may be severely biased. A frequent…

Methodology · Statistics 2018-03-23 Maria Francesca Marino , Marco Alfo'

People are living longer than ever before, and with this arises new complications and challenges for humanity. Among the most pressing of these challenges is of understanding the role of aging in the development of dementia. This paper is…

Methodology · Statistics 2018-08-07 Jonathan P Williams , Curtis B Storlie , Terry M Therneau , Clifford R Jack , Jan Hannig

Men and women differ in specific cognitive abilities and in the expression of several neuropsychiatric conditions. Such findings could be attributed to sex hormones, brain differences, as well as a number of environmental variables.…

Applications · Statistics 2016-05-10 Zi Wang , Vyacheslav Karolis , Chiara Nosarti , Giovanni Montana

We introduce a probabilistic (Bayesian) framework and associated software toolbox for mapping population receptive fields (pRFs) based on fMRI data. This generic approach is intended to work with stimuli of any dimension and is demonstrated…

Neurons and Cognition · Quantitative Biology 2018-05-21 Peter Zeidman , Edward Harry Silson , Dietrich Samuel Schwarzkopf , Chris Ian Baker , Will Penny

The Markov Transition Field (MTF), introduced by Wang and Oates (2015), encodes a time series as a two-dimensional image by mapping each pair of time steps to the transition probability between their quantile states, estimated from a single…

Machine Learning · Computer Science 2026-03-11 Michael Leznik

Despite the impact of psychiatric disorders on clinical health, early-stage diagnosis remains a challenge. Machine learning studies have shown that classifiers tend to be overly narrow in the diagnosis prediction task. The overlap between…

The parameters of a discrete stationary Markov model are transition probabilities between states. Traditionally, data consist in sequences of observed states for a given number of individuals over the whole observation period. In such a…

Computation · Statistics 2012-04-30 Alberto Pasanisi , Shuai Fu , Nicolas Bousquet

Human brain development is a complex and dynamic process that begins during the first weeks of pregnancy and lasts until early adulthood. This chapter focuses on the developmental window from prenatal period to infancy, probably the most…

Neurons and Cognition · Quantitative Biology 2025-05-01 Arnaud Cachia , Jean-François Mangin , Jessica Dubois

Machine learning provides a valuable tool for analyzing high-dimensional functional neuroimaging data, and is proving effective in predicting various neurological conditions, psychiatric disorders, and cognitive patterns. In functional…

Machine Learning · Computer Science 2024-11-25 Anwar Said , Roza G. Bayrak , Tyler Derr , Mudassir Shabbir , Daniel Moyer , Catie Chang , Xenofon Koutsoukos

Constraining the many biological parameters that govern cortical dynamics is computationally and conceptually difficult because of the curse of dimensionality. This paper addresses these challenges by proposing (1) a novel data-informed…

Neurons and Cognition · Quantitative Biology 2021-12-30 Zhuo-Cheng Xiao , Kevin K. Lin , Lai-Sang Young

Identifying and utilising various biomarkers for tracking Alzheimer's disease (AD) progression have received many recent attentions and enable helping clinicians make the prompt decisions. Traditional progression models focus on extracting…

Machine Learning · Computer Science 2023-11-08 Xulong Wang , Yu Zhang , Menghui Zhou , Tong Liu , Jun Qi , Po Yang

Background: Reliable prediction of clinical progression over time can improve the outcomes of depression. Little work has been done integrating various risk factors for depression, to determine the combinations of factors with the greatest…

Machine Learning · Statistics 2023-07-06 Runa Bhaumik , Jonathan Stange

Smart systems that can accurately diagnose patients with mental disorders and identify effective treatments based on brain functional imaging data are of great applicability and are gaining much attention. Most previous machine learning…

Computer Vision and Pattern Recognition · Computer Science 2017-12-05 Jumana Dakka , Pouya Bashivan , Mina Gheiratmand , Irina Rish , Shantenu Jha , Russell Greiner

Several brain disorders can be detected by observing alterations in the brain's structural and functional connectivities. Neurological findings suggest that early diagnosis of brain disorders, such as mild cognitive impairment (MCI), can…

Neurons and Cognition · Quantitative Biology 2021-10-22 Alpay Tekin , Ahmed Nebli , Islem Rekik

The surface morphology of the developing mammalian brain is crucial for understanding brain function and dysfunction. Computational modeling offers valuable insights into the underlying mechanisms for early brain folding. Recent findings…

Neurons and Cognition · Quantitative Biology 2024-09-06 Jixin Hou , Zhengwang Wu , Xianyan Chen , Li Wang , Dajiang Zhu , Tianming Liu , Gang Li , Xianqiao Wang

We consider learning a sparse pairwise Markov Random Field (MRF) with continuous-valued variables from i.i.d samples. We adapt the algorithm of Vuffray et al. (2019) to this setting and provide finite-sample analysis revealing sample…

Machine Learning · Computer Science 2020-10-29 Abhin Shah , Devavrat Shah , Gregory W. Wornell

Mathematical models are becoming increasingly important in magnetic resonance imaging (MRI), as they provide a mechanistic approach for making a link between tissue microstructure and signals acquired using the medical imaging instrument.…

Medical Physics · Physics 2021-06-10 Viktor Vegh , Shahrzad Moinian , Qianqian Yang , David C. Reutens

Functional magnetic resonance imaging (fMRI) is a neuroimaging technique that records neural activations in the brain by capturing the blood oxygen level in different regions based on the task performed by a subject. Given fMRI data, the…

Computer Vision and Pattern Recognition · Computer Science 2021-09-21 Ashish Jaiswal , Ashwin Ramesh Babu , Mohammad Zaki Zadeh , Fillia Makedon , Glenn Wylie
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