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Disease in the brain is often associated with subtle, spatially diffuse, or complex tissue changes that may lie beneath the level of gross visual inspection, even on magnetic resonance imaging (MRI). Unfortunately, current computer-assisted…

Computer Vision and Pattern Recognition · Computer Science 2017-05-16 Shinjini Kundu , Soheil Kolouri , Kirk I Erickson , Arthur F Kramer , Edward McAuley , Gustavo K Rohde

Characterizing the transcriptome architecture of the human brain is fundamental in gaining an understanding of brain function and disease. A number of recent studies have investigated patterns of brain gene expression obtained from an…

Neurons and Cognition · Quantitative Biology 2016-10-11 Zhana Kuncheva , Michelle L. Krishnan , Giovanni Montana

Restricted Boltzmann Machine (RBM) is a generative stochastic neural network that can be applied to collaborative filtering technique used by recommendation systems. Prediction accuracy of the RBM model is usually better than that of other…

Machine Learning · Computer Science 2019-10-16 Pei Yang , Srinivas Varadharajan , Lucas A. Wilson , Don D. Smith , John A Lockman , Vineet Gundecha , Quy Ta

Phase-field (PF) simulation provides a powerful framework for predicting microstructural evolution but suffers from prohibitive computational costs that severely limit accessible spatiotemporal scales in practical applications. While…

We investigate the parameter recovery of Markov-switching ordinary differential processes from discrete observations, where the differential equations are nonlinear additive models. This framework has been widely applied in biological…

Methodology · Statistics 2025-01-03 Katherine Tsai , Mladen Kolar , Sanmi Koyejo

We introduce a new approach to probabilistic unsupervised learning based on the recognition-parametrised model (RPM): a normalised semi-parametric hypothesis class for joint distributions over observed and latent variables. Under the key…

Machine Learning · Computer Science 2023-04-21 William I. Walker , Hugo Soulat , Changmin Yu , Maneesh Sahani

In this paper, we will show that the recently introduced graphical model: Conditional Random Fields (CRF) provides a template to integrate micro-level information about biological entities into a mathematical model to understand their…

Machine Learning · Computer Science 2020-08-07 Lior Lukov , Sanjay Chawla , Wei Liu , Brett Church , Gaurav Pandey

The spectral content of macroscopic neural activity evolves throughout development, yet how this maturation relates to underlying brain network formation and dynamics remains unknown. Here, we assess the developmental maturation of…

Time-varying networks are fast emerging in a wide range of scientific and business disciplines. Most existing dynamic network models are limited to a single-subject and discrete-time setting. In this article, we propose a mixed-effect…

Methodology · Statistics 2018-06-12 Jingfei Zhang , Will Wei Sun , Lexin Li

Modern imaging techniques for probing brain function, including functional Magnetic Resonance Imaging, intrinsic and extrinsic contrast optical imaging, and magnetoencephalography, generate large data sets with complex content. In this…

Neurons and Cognition · Quantitative Biology 2009-11-10 P. P. Mitra , B. Pesaran

A visual system has to learn both which features to extract from images and how to group locations into (proto-)objects. Those two aspects are usually dealt with separately, although predictability is discussed as a cue for both. To…

Computer Vision and Pattern Recognition · Computer Science 2022-05-31 Heiko H. Schütt , Wei Ji Ma

While studies show that autism is highly heritable, the nature of the genetic basis of this disorder remains illusive. Based on the idea that highly correlated genes are functionally interrelated and more likely to affect risk, we develop a…

Methodology · Statistics 2015-11-18 Li Liu , Jing Lei , Kathryn Roeder

We consider the problem of learning graphical models, also known as Markov random fields (MRFs) from temporally correlated samples. As in many traditional statistical settings, fundamental results in the area all assume independent samples…

Machine Learning · Computer Science 2024-11-05 Jason Gaitonde , Ankur Moitra , Elchanan Mossel

In the past five years, the use of generative and foundational AI systems has greatly improved the decoding of brain activity. Visual perception, in particular, can now be decoded from functional Magnetic Resonance Imaging (fMRI) with…

Image and Video Processing · Electrical Eng. & Systems 2024-03-15 Yohann Benchetrit , Hubert Banville , Jean-Rémi King

Understanding human fetal neurodevelopment is of great clinical importance as abnormal development is linked to adverse neuropsychiatric outcomes after birth. Recent advances in functional Magnetic Resonance Imaging (fMRI) have provided new…

Image and Video Processing · Electrical Eng. & Systems 2019-06-11 Xiangrui Li , Jasmine Hect , Moriah Thomason , Dongxiao Zhu

Dynamic brain data, teeming with biological and functional insights, are becoming increasingly accessible through advanced measurements, providing a gateway to understanding the inner workings of the brain in living subjects. However, the…

Neurons and Cognition · Quantitative Biology 2025-08-19 Zixia Zhou , Junyan Liu , Wei Emma Wu , Ruogu Fang , Sheng Liu , Qingyue Wei , Rui Yan , Yi Guo , Qian Tao , Yuanyuan Wang , Md Tauhidul Islam , Lei Xing

Traditionally, graph neural networks have been trained using a single observed graph. However, the observed graph represents only one possible realization. In many applications, the graph may encounter uncertainties, such as having…

Machine Learning · Computer Science 2024-10-10 See Hian Lee , Feng Ji , Kelin Xia , Wee Peng Tay

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

While Markov Random Fields (MRFs) are widely used in computer vision, they present a quite challenging inference problem. MRF inference can be accelerated by pre-processing techniques like Dead End Elimination (DEE) or QPBO-based approaches…

Computer Vision and Pattern Recognition · Computer Science 2017-08-10 Chen Wang , Charles Herrmann , Ramin Zabih

Brain aging is a regional phenomenon, a facet that remains relatively under-explored within the realm of brain age prediction research using machine learning methods. Voxel-level predictions can provide localized brain age estimates that…

Computer Vision and Pattern Recognition · Computer Science 2024-04-26 Neha Gianchandani , Mahsa Dibaji , Johanna Ospel , Fernando Vega , Mariana Bento , M. Ethan MacDonald , Roberto Souza