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Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) govern a daunting number of physiological processes. For such proteins, molecular mechanisms governing their interactions with proteins…
Ion channels are proteins with a hole down the middle embedded in cell membranes. Membranes form insulating structures and the channels through them allow and control the movement of charged particles, spherical ions, mostly Na+, K+, Ca++,…
We use Brownian dynamics simulations to study the permeation properties of a generic electrostatic model of a biological ion channel as a function of the fixed charge $Q_f$ at its selectivity filter. We reconcile the recently-discovered…
The dynamics of phase-separated interfaces shape the behavior of both passive and active condensates. While surface tension in equilibrium systems minimizes interface length, non-equilibrium fluxes can destabilize flat or constantly curved…
The macroscopic spreading and mixing of solute plumes in saturated porous media is ultimately controlled by processes operating at the pore scale. Whilst the conventional picture of pore-scale mechanical dispersion and molecular diffusion…
Intracellular protein patterns regulate a variety of vital cellular processes such as cell division and motility, which often involve dynamic changes of cell shape. These changes in cell shape may in turn affect the dynamics of…
It is shown, by means of numerical simulations, that intercellular spiral waves of calcium can be initiated in a network of coupled cells as a result of a de-synchronization between Ca2+ oscillations in two domains. No artificial…
Microchannels are well-known in microfluidic applications for the control and separation of microdroplets and cells. Often the objects in the flow experience inertial effects, resulting in dynamics that is a departure from the underlying…
The accumulation of potassium in the extracellular space surrounding nerve cells is a fundamental aspect of biophysics that has garnered significant attention in recent research. This phenomenon holds implications for various neurological…
Small finite-size particles suspended in fluid flow through an enclosed curved duct can focus to points or periodic orbits in the two-dimensional duct cross-section. This particle focusing is due to a balance between inertial lift forces…
Clays control carbon, water and nutrient transport in the lithosphere, promote cloud formation5 and lubricate fault slip through interactions among hydrated mineral interfaces. Clay mineral properties are difficult to model because their…
It is known that curvature relation plays a key role in the propagation of two-dimensional waves in an excitable model. Such a relation is believed to obey the eikonal equation for typical excitable models (e.g., the FitzHugh-Nagumo (FHN)…
Widefield calcium imaging has recently emerged as a powerful experimental technique to record coordinated large-scale brain activity. These measurements present a unique opportunity to characterize spatiotemporal coherent structures that…
Toxoplasma gondii is the causative agent responsible for toxoplasmosis and serves as one of the most common parasites in the world. For a successful lytic cycle, T. gondii must traverse biological barriers in order to invade host cells, and…
We propose a theory for erosional channelization induced by fluid flow in a saturated granular porous medium. When the local fluid flow-induced stress is larger than a critical threshold, grains are dislodged and carried away so that the…
The usability of enzymatically induced calcium carbonate precipitation (EICP) as a method for altering porous-media properties, soil stabilization, or biocementation depends on our ability to predict the spatial distribution of the…
Potassium channels play critical roles in many physiological processes, providing a selective permeation route for K+ ions in and out of a cell, by employing a carefully designed selectivity filter, evolutionarily conserved from viruses to…
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map.…
In colloidal systems, Brownian motion emerges from the massive separation of time and length scales associated to characteristic dynamics of the solute and solvent constituents. This separation of scales produces several temporal regimes in…
Ion channels are membrane proteins responsible for an enormous range of biological functions. Ion selectivity and permeation are based on simple laws of physics and chemistry. Ion channels are therefore ideal candidates for physical…