We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
@article{arxiv.physics/0405048,
title = {Coupled dynamics of voltage and calcium in paced cardiac cells},
author = {Yohannes Shiferaw and Daisuke Sato and Alain Karma},
journal= {arXiv preprint arXiv:physics/0405048},
year = {2009}
}