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In numerous systems in biophysics and related fields, scientists measure (with very smart methods) individual molecules (e.g. biopolymers (proteins, DNA, RNA, etc), nano - crystals, ion channels), aiming at finding a model from the data.…
Trapping, linearization, and imaging of single molecule DNA is of broad interest to both biophysicists who study polymer physics and engineers who build nucleic acid analyzing methods such as optical mapping. In this study, single DNA…
We present a thorough analysis of single atom detection using optical cavities. The large set of parameters that influence the signal-to-noise ratio for cavity detection is considered, with an emphasis on detunings, probe power, cavity…
Single-photon detectors are an essential part of the toolbox of modern quantum optics for implementing quantum technologies and enabling tests of fundamental physics. The low energy of microwave photons, the natural signal path for…
Engineered electromagnetic fields in plasmonic nanopores enable enhanced optical detection and their use in single molecule sequencing. Here, a plasmonic nanopore prepared in a thick nanoporous film is used to investigate the interaction…
Nanomagnetometry using the nitrogen-vacancy (NV) centre in diamond has attracted a great deal of interest because of the combined features of room temperature operation, nanoscale resolution and high sensitivity. One of the important goals…
A nanoparticle detection scheme with single particle resolution is presented. The sensor contains only a taper fiber thus offering the advantages of compactness and installation flexibility. Sensing method is based on monitoring the…
We show that single-atoms can be trapped on the surface of a subwavelength-diameter silica-fiber, an optical nanofiber, without any external field, and that single photons spontaneously emitted from the atoms can be readily detected through…
Determining the number of fluorescent entities that are coupled to a given molecule (DNA, protein, etc.) is a key point of numerous biological studies, especially those based on a single molecule approach. Reliable methods are important, in…
We demonstrate an optical method for detecting the mechanical oscillations of an atom with single-phonon sensitivity. The measurement signal results from the interference between the light scattered by a single trapped atomic ion and that…
Single molecules that exhibit narrow optical transitions at cryogenic temperatures can be used as local electric-field sensors. We derive the single charge sensitivity of aromatic organic dye molecules, based on first principles. Through…
A reliable photon source is required for many aspects of quantum technology. Organic molecules are attractive for this application because they can have high quantum yield and can be photostable, even at room temperature. To generate a…
All optical detectors to date annihilate photons upon detection, thus excluding repeated measurements. Here, we demonstrate a robust photon detection scheme which does not rely on absorption. Instead, an incoming photon is reflected off an…
Direct monitoring of singlet oxygen (1O2) luminescence is a particularly challenging infrared photodetection problem. 1O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low…
In the realm of fundamental quantum science and technologies, non-classical states of light, such as single-photon Fock states, are widely studied. However, current standards and metrological procedures are not optimized for low light…
We investigate the optical detection of single atoms held in a microscopic atom trap close to a surface. Laser light is guided by optical fibers or optical micro-structures via the atom to a photo-detector. Our results suggest that with…
Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…
Detecting individual light quanta is essential for quantum information, space exploration, advanced machine vision, and fundamental science. Here, we introduce a novel single photon detection mechanism using highly photosensitive…
Synthetic molecular motors are an appealing means to control motion at the nanoscale, but understanding their behaviour as single-molecule actuators and integrating them into larger, functional systems remain technical challenges.…
We propose and demonstrate a novel technique that combines Raman scattering and optical cycling in molecules with diagonal Franck-Condon factors. This resonance Raman optical cycling manipulates molecules to behave like efficient…