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Confocal microscopy has long been a cornerstone technique for visualizing complex interactions and processes within cellular structures. However, achieving super-resolution imaging of multiple organelles and their interactions…

Optics · Physics 2025-08-19 Qinglin Chen , Luwei Wang , Jia Li , Dan Shao , Xiaoyu Weng , Liwei Liu , Dayong Jin , Junle Qu

Flexible fiber-optic endoscopes provide a minimally-invasive solution for imaging at depths beyond the reach of conventional microscopes. Current endoscopes require focusing and/or scanning mechanisms at the distal end, which limit…

Reflectance Confocal Microscopy (RCM) is a non-invasive imaging technique used in biomedical research and clinical dermatology. It provides virtual high-resolution images of the skin and superficial tissues, reducing the need for physical…

Image and Video Processing · Electrical Eng. & Systems 2024-04-26 Hong-Jun Yoon , Chris Keum , Alexander Witkowski , Joanna Ludzik , Tracy Petrie , Heidi A. Hanson , Sancy A. Leachman

Microscopes face a trade-off between spatial resolution, field-of-view, and frame rate -- improving one of these properties typically requires sacrificing the others, due to the limited spatiotemporal throughput of the sensor. To overcome…

The use of multimode fibers offers advantages in the field of communication technology in terms of transferable information density and information security. For applications using physical layer security or mode division multiplexing, the…

Image and Video Processing · Electrical Eng. & Systems 2021-04-21 Stefan Rothe , Qian Zhang , Nektarios Koukourakis , Jürgen W. Czarske

A recently introduced two-channel confocal microscope with correlated detection promises up to 50% improvement in transverse spatial resolution [Simon, Sergienko, Optics Express {\bf 18}, 9765 (2010)] via the use of photon correlations.…

Quantum Physics · Physics 2015-05-18 D. S. Simon , A. V. Sergienko

We present a physics-informed deep learning framework to address common limitations in Confocal Laser Scanning Microscopy (CLSM), such as diffraction limited resolution, noise, and undersampling due to low laser power conditions. The…

Materials Science · Physics 2025-01-27 Zaheer Ahmad , Junaid Shabeer , Usman Saleem , Tahir Qadeer , Abdul Sami , Zahira El Khalidi , Saad Mehmood

Holographic wavefront manipulation enables converting hair-thin multimode optical fibres into minimally invasive lensless imaging instruments conveying much higher information densities than conventional endoscopes. Their most prominent…

Endoscopes are an important component for the development of minimally invasive surgeries. Their size is one of the most critical aspects, because smaller and less rigid endoscopes enable higher agility, facilitate larger accessibility, and…

Directly imaging and characterizing Earth-like exoplanets is a tremendously difficult instrumental challenge. Present coronagraphic systems have yet to achieve the required $10^{-10}$ broadband contrast in a laboratory environment, but…

Instrumentation and Methods for Astrophysics · Physics 2019-07-10 Carl T. Coker , Stuart B. Shaklan , A J E. Riggs , Garreth Ruane

Speckle-correlation imaging techniques are widely used for non-invasive imaging through complex scattering media. While light propagation through multimode fibers and scattering media share many analogies, reconstructing images through…

We present a new Multimodal Fiber Array Snapshot Technique (M-FAST), based on an array of 96 compact cameras placed behind a primary objective lens and a fiber bundle array. which is capable of large-area, high-resolution, multi-channel…

Light transport in a highly multimode fiber exhibits complex behavior in space, time, frequency and polarization, especially in the presence of mode coupling. The newly developed techniques of spatial wavefront shaping turn out to be highly…

Optics · Physics 2023-07-06 Hui Cao , Tomáš Čižmár , Sergey Turtaev , Tomáš Tyc , Stefan Rotter

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…

We developed an ultra-compact high-resolution imaging system for cold atoms. Its only in-vacuum element is a multimode optical fiber with a diameter of $230\,\mu$m, which simultaneously collects light and guides it out of the vacuum…

Atomic Physics · Physics 2021-06-23 Nicolas Vitrant , Sébastien Garcia , Kilian Müller , Alexei Ourjoumtsev

This paper presents a coherent linking approach between confocal amplitude and confocal phase images acquired using dual-comb microscopy (DCM). DCM combines the advantages of confocal laser microscopy and quantitative phase microscopy,…

The resolution of optical imaging devices is ultimately limited by the diffraction of light. To circumvent this limit, modern super-resolution microscopy techniques employ active interaction with the object by exploiting its optical…

Optics · Physics 2022-01-05 A. A. Pushkina , G. Maltese , J. I. Costa-Filho , P. Patel , A. I. Lvovsky

We introduce a novel laser-scanning optical microscopy technique that employs optical-frequency-comb (OFC) lasers. This method facilitates multimodal spectroscopic imaging by analyzing interferograms produced via a dual-comb spectroscopic…

Confocal microscopy is the cornerstone of cellular biology and biomedical research due to its non-destructive imaging, compatibility with live cells, sensitivity, optical sectioning, and subcellular resolution. To meet the demand for rapid…

We demonstrate pixelation-free real-time widefield endoscopic imaging through an aperiodic multicore fiber (MCF) without any distal opto-mechanical elements or proximal scanners. Exploiting the memory effect in MCFs the images in our system…