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A flexible multimode fiber is an exceptionally efficient tool for in vivo deep tissue imaging. Recent advances in compressive multimode fiber sensing allow for imaging with sub-diffraction spatial resolution and sub-Nyquist speed. At…

Optics · Physics 2024-07-17 Zhouping Lyu , Shih-Te Hung , Carlas S. Smith , Lyubov V. Amitonova

Fast, volumetric imaging over large scales has been a long-standing goal in biological microscopy. Scanning techniques such as fluorescence confocal microscopy can acquire 2D images at high resolution and high speed, but extending the…

In this work we demonstrate 3D imaging using two-photon excitation through a 20 cm long multimode optical fiber (MMF) of 350 micrometers diameter. The imaging principle is similar to single photon fluorescence through a MMF, except that a…

Optics · Physics 2016-01-20 Edgar E. Morales-Delgado , Demetri Psaltis , Christophe Moser

We demonstrate sub-wavelength sectioning on biological samples with a conventional confocal microscope. This optical sectioning is achieved by the phenomenon of supercritical angle fuorescence, wherein only a fluorophore next to the…

We propose and demonstrate two methods for modal decomposition in multi-mode fibres. Linearly polarized modes propagating in a slightly multi-mode fibre are easily retrieved from intensity measurements at the fibre output surface. The first…

We demonstrate Optical-Resolution Photoacoustic Microscopy (OR-PAM), where the optical field is focused and scanned using Digital Phase Conjugation (DPC) through a multimode fiber. The focus is scanned across the field of view using digital…

Holographic multimode fibre endoscopes have recently shown their ability to unveil and monitor deep brain structures with sub-micrometre resolution, establishing themselves as a minimally-invasive technology with promising applications in…

Fiber-based endoscopes utilizing multi-core fiber (MCF) bundles offer the capability to image deep within the human body, making them well-suited for imaging applications in minimally invasive surgery or diagnosis. However, the optical…

Snapshot spectral imaging is rapidly gaining interest for remote sensing applications. Acquiring spatial and spectral data within one image promotes fast measurement times, and reduces the need for stabilized scanning imaging systems. Many…

Image and Video Processing · Electrical Eng. & Systems 2018-12-05 Rebecca French , Sylvain Gigan , Otto L. Muskens

Confocal Raman microscopy, a highly specific and label-free technique for the microscale study of thick samples, often presents difficulties due to weak Raman signals. Inhomogeneous samples introduce wavefront aberrations that further…

Confocal microscopy is the backbone of cellular research labs across the world but unfortunately, the imaging is restricted to a single plane. Chromatic confocal microscopy offers the possibility to image multiple planes simultaneously thus…

Optics · Physics 2022-02-01 Gargi Sharma , Kanwarpal Singh

With the advent of neuroimaging and microsurgery, there is a rising need for capturing images through an optical fiber. We present an approach of imaging through a single fiber without mechanical scanning by implementing spatial-spectral…

A multimode fiber represents the ultimate limit in miniaturization of imaging endoscopes. Here we propose a fiber imaging approach employing compressive sensing with a data-driven machine learning framework. We implement a generative…

Image and Video Processing · Electrical Eng. & Systems 2022-10-14 Wei Li , Ksenia Abrashitova , Gerwin Osnabrugge , Lyubov V. Amitonova

We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and…

We theoretically study the problem of detecting dipole radiation in an optical system of high numerical aperture in which the detector is sensitive to \textit{field amplitude}. In particular, we model the phase sensitive detector as a…

Multimode fibres offer the advantages of high resolution and miniaturization over single mode fibers in the field of optical imaging. However, multimode fibre's imaging is susceptible to perturbations of MMF that can lead to secondary…

Endomicroscopy is an emerging imaging modality, that facilitates the acquisition of in vivo, in situ optical biopsies, assisting diagnostic and potentially therapeutic interventions. While there is a diverse and constantly expanding range…

Computer Vision and Pattern Recognition · Computer Science 2020-01-01 Antonios Perperidis , Kevin Dhaliwal , Stephen McLaughlin , Tom Vercauteren

We propose to use high numerical aperture single mode optical fibers like photonic crystal fiber for lensless in-line holographic microscopy. Highly divergent beam helps to overcome the spatial sampling limitation of the image sensor. In…

Optics · Physics 2020-07-01 Sanjeev Kumar , Manjunatha Mahadevappa , Pranab K. Dutta

We study the diffraction of a particular class of beams, composed only by a combination of azimuthally invariant guided modes of an optical fiber. We demonstrate that such beams can be obtained by injecting a Gaussian beam in a small piece…

The confocal microwave imaging (CMI) algorithm, which is used in radar imaging, has been applied to microwave medical imaging (MMI) [1, 2]. In MMI, the diseased region to be imaged has different electromagnetic characteristics from that of…

Medical Physics · Physics 2024-10-01 Wenyi Shao , Beibei Zhou , Gang Wang