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Related papers: Predicting binding free energies in solution

200 papers

In this paper we study computationally feasible bounds for relative free energies between two many-particle systems. Specifically, we consider systems out of equilibrium that do not necessarily satisfy a fluctuation-dissipation relation,…

Statistical Mechanics · Physics 2024-03-19 Luigi Delle Site , Carsten Hartmann

Recent progress on molecular theories of hydration of nonpolar solutes in aqueous solution has led to new ways of thinking about the old issue of free, or "available," volume in liquids. This article surveys the principal new results with…

Chemical Physics · Physics 2007-05-23 Lawrence R. Pratt , Shekhar Garde , Gerhard Hummer

Binding energies calculated from using the Bethe-Salpeter equation in the simplest ladder approximation significantly differ from those obtained in the non-relativistic standard instantaneous approximation. While they should a priori be…

Nuclear Theory · Physics 2007-05-23 G. Le Gorrec , B. Desplanques

Simplified, classical models of water are an integral part of atomistic molecular simulations, especially in biology and chemistry where hydration effects are critical. Yet, despite several decades of effort, these models are still far from…

Chemical Physics · Physics 2015-01-13 Saeed Izadi , Ramu Anandakrishnan , Alexey V. Onufriev

For a 2-dimensional freely jointed chain with 3 particles and a related model, the average and variance of the kinetic energies of each particle in thermal equilibrium are exactly obtained. The same is done for a related model. The excess…

Statistical Mechanics · Physics 2021-10-01 Tetsuro Konishi , Tatsuo Yanagita

We present high-quality reference data for two fundamentally important groups of molecular properties related to a compound's utility as a lithium battery electrolyte. The first property is energy changes associated with charge excitations…

Molecular dynamics simulations with separate thermostats for rotational and translational motions were used to study the effects of these degrees of freedom on the structure of water at a fixed density. To describe water molecules, we used…

Soft Condensed Matter · Physics 2015-04-06 T. Mohorič , B. Hribar-Lee , V. Vlachy

The response of polar solvents to ions and polar molecules dictates many fundamental molecular processes. To understand such electrostatically-driven solvation processes, one ideally would probe the dielectric response of a solvent to an…

Chemical Physics · Physics 2025-08-12 Renjie Zhao , Richard C. Remsing , John D. Weeks

We show that charge-sign-dependent asymmetric hydration can be modeled accurately using linear Poisson theory but replacing the standard electric-displacement boundary condition with a simple nonlinear boundary condition. Using a single…

Chemical Physics · Physics 2015-06-23 Jaydeep P. Bardhan , Matthew G. Knepley

The tight binding model is a minimal electronic structure model for molecular modelling and simulation. We show that the total energy in this model can be decomposed into site energies, that is, into contributions from each atomic site…

Numerical Analysis · Mathematics 2015-06-19 Huajie Chen , Christoph Ortner

The binding energy of A3C60, a conductor, is described well by an ionic solid type calculation. This succeeds because there is little overlap between molecular wave functions on neighbouring sites, so that electrons are practically…

Materials Science · Physics 2007-05-23 K. Ranjan , Sarbpreet Singh , K. Dharamvir , V. K. Jindal

Using computer simulations, we validate a simple free energy model that can be analytically solved to predict the equilibrium size of self-limiting clusters of particles in the fluid state governed by a combination of short-range attractive…

Soft Condensed Matter · Physics 2016-08-25 Jonathan A. Bollinger , Thomas M. Truskett

The critical behavior of a 3D Ising-like system is studied at the microscopic level of consideration. The free energy of ordering is calculated analytically as an explicit function of temperature, an external field and the initial…

Statistical Mechanics · Physics 2012-02-22 M. P. Kozlovskii , R. V. Romanik

The present study aims at further development of covariant energy density functionals (CEDFs) towards more accurate description of binding energies across the nuclear chart. For the first time, infinite basis corrections to binding energies…

Nuclear Theory · Physics 2025-07-29 B. Osei , A. V. Afanasjev , A. Taninah , A. Dalbah , U. C. Perera , V. A. Dzuba , V. V. Flambaum

We examine the influence of the main approximations employed in density-functional theory descriptions of the solid phase of molecular hydrogen near dissociation. We consider the importance of nuclear quantum effects on equilibrium…

Materials Science · Physics 2015-06-15 M. A. Morales , J. M. McMahon , C. Pierleoni , D. M. Ceperley

We present a simple, unified theory for the self-energy of an ion near a dielectric interface. Our theory accounts for both the short-range (solvation) and long-range (image force) electrostatic forces, charge polarization induced by these…

Soft Condensed Matter · Physics 2015-06-17 Rui Wang , Zhen-Gang Wang

Molecular dynamics simulations of water with both multi-Kr and single Kr atomic solutes are carried out to implement quasi-chemical theory evaluation of the hydration free energy of Kr(aq). This approach obtains free energy differences…

Chemical Physics · Physics 2014-11-07 M. I. Chaudhari , D. Sabo , L. R. Pratt , S. B. Rempe

The binding-energy differences for $^{163}\mathrm{Ho}^{q+}$ and $^{163}\mathrm{Dy}^{q+}$ ions with ionization degrees $q = 38$, $39$, and $40$ are calculated. The calculations are performed using the large-scale relativistic…

Atomic Physics · Physics 2023-08-28 I. M. Savelyev , M. Y. Kaygorodov , Y. S. Kozhedub , I. I. Tupitsyn , V. M. Shabaev

We use a shell model to study the counterion interactions in a colloidal solution. In this shell model, the counterions are restricted to move inside a spherical region about their host colloidal particle. In particular, we apply Monte…

Soft Condensed Matter · Physics 2012-02-09 Chi-Lun Lee

Complexation in symmetric solutions of oppositely charged polyelectrolytes is studied theoretically. We include polyion crosslinking due to formation of thermoreversible ionic pairs. The electrostatic free energy is calculated within the…

Soft Condensed Matter · Physics 2009-11-10 Alexander Kudlay , Alexander V. Ermoshkin , Monica Olvera de la Cruz