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Autoinducers are small signaling molecules that mediate intercellular communication in microbial populations and trigger coordinated gene expression via "quorum sensing". Elucidating the mechanisms that control autoinducer production is,…

Populations and Evolution · Quantitative Biology 2017-07-26 Matthias Bauer , Johannes Knebel , Matthias Lechner , Peter Pickl , Erwin Frey

Microorganisms employ sophisticated mechanisms for intercellular communication and environmental sensing, with quorum sensing serving as a fundamental regulatory process. Dysregulation of quorum sensing has been implicated in various…

Emerging Technologies · Computer Science 2025-09-30 O. Tansel Baydas , Efe Yatgin , Ozgur B. Akan

Bacteria communicate using secreted chemical signaling molecules called autoinducers in a process known as quorum sensing. The quorum-sensing network of the marine bacterium {\it Vibrio harveyi} employs three autoinducers, each known to…

Molecular Networks · Quantitative Biology 2009-05-27 Pankaj Mehta , Sidhartha Goyal , Tao Long , Bonnie Bassler , Ned S. Wingreen

Bacteria communicate using external chemical signals called autoinducers (AI) in a process known as quorum sensing (QS). QS efficiency is reduced by both limitations of AI diffusion and potential interference from neighboring strains. There…

Molecular Networks · Quantitative Biology 2016-12-28 Tahir I. Yusufaly , James Q. Boedicker

Quorum sensing is a decentralized biological process, through which a community of cells with no global awareness coordinate their functional behaviors based solely on cell-medium interactions and local decisions. This paper draws…

Machine Learning · Computer Science 2015-10-08 Feng Tan , Jean-Jacques Slotine

Within the context of evolution, an altruistic act that benefits the receiving individual at the expense of the acting individual is a puzzling phenomenon. An extreme form of altruism can be found in colicinogenic E. coli. These suicidal…

Neural and Evolutionary Computing · Computer Science 2016-03-31 Anya Elaine Johnson , Eli Strauss , Rodney Pickett , Christoph Adami , Ian Dworkin , Heather J. Goldsby

We study the role of Quorum Sensing (QS) in the growth of bacterial colonies and in the bioluminescence produced. These two phenomena are both regulated by QS and the experimental data show a non-trivial correlation between them. It is also…

Biological Physics · Physics 2023-10-27 E. Alfinito , M. Beccaria , M. Cesaria

The exchange of small molecular signals within microbial populations is generally referred to as quorum sensing (QS). QS is ubiquitous in nature and enables microorganisms to respond to fluctuations in living environments by working…

Cell Behavior · Quantitative Biology 2019-09-16 Yuting Fang , Adam Noel , Andrew W. Eckford , Nan Yang

Bacteria populations rely on mechanisms such as quorum sensing to coordinate complex tasks that cannot be achieved by a single bacterium. Quorum sensing is used to measure the local bacteria population density, and it controls cooperation…

Cell Behavior · Quantitative Biology 2018-02-14 Adam Noel , Yuting Fang , Nan Yang , Dimitrios Makrakis , Andrew W. Eckford

"Secrete-and-sense cells" can communicate by secreting a signaling molecule while also producing a receptor that detects the molecule. The cell can potentially "talk" to itself ("self-communication") or talk to neighboring cells with the…

Cell Behavior · Quantitative Biology 2017-08-10 Berkalp A. Doğaner , Lawrence K. Q. Yan , Hyun Youk

In quorum sensing (QS), bacteria exchange molecular signals to work together. An analytically-tractable model is presented for characterizing QS signal propagation within a population of bacteria and the number of responsive cooperative…

Information Theory · Computer Science 2020-09-03 Yuting Fang , Adam Noel , Andrew W. Eckford , Nan Yang , Jing Guo

Maintenance of plasma IgM levels is critical for immune system function and homeostasis in humans and mice. However, the mechanisms that control homeostasis of the activated IgM-secreting B cells are unknown. After adoptive transfer into…

Bacteria are easily characterizable model organisms with an impressively complicated set of capabilities. Among their capabilities is quorum sensing, a detailed cell-cell signaling system that may have a common origin with eukaryotic…

Neurons and Cognition · Quantitative Biology 2017-09-14 Archana Ram , Andrew Lo

The design of biological networks using bacteria as the basic elements of the network is initially motivated by a phenomenon called quorum sensing. Through quorum sensing, each bacterium performs sensing the medium and communicating it to…

Information Theory · Computer Science 2012-05-23 Arash Einolghozati , Mohsen Sardari , Faramarz Fekri

Microbial communities frequently communicate via quorum sensing (QS), where cells produce, secrete, and respond to a threshold level of an autoinducer (AI) molecule, thereby modulating gene expression. However, the biology of QS remains…

Molecular Networks · Quantitative Biology 2017-08-02 Tahir Yusufaly , James Q. Boedicker

Quorum sensing is the mechanism by which bacteria communicate and synchronize group behaviors. Quantitative information on parameters such as the copy number of particular quorum-sensing proteins should contribute strongly to understanding…

Quantitative Methods · Quantitative Biology 2015-05-14 Shu-Wen Teng , Yufang Wang , Kimberly C. Tu , Tao Long , Pankaj Mehta , Ned S. Wingreen , Bonnie L. Bassler , N. P. Ong

A cooperative drug delivery system is proposed, where quorum sensing (QS), a density-dependent bacterial behavior coordination mechanism, is employed by synthetic bacterium-based nanomachines (B-NMs) for controllable drug delivery. In our…

Quantitative Methods · Quantitative Biology 2023-03-15 Yuting Fang , Stuart T. Johnston , Matt Faria , Xinyu Huang , Andrew W. Eckford , Jamie Evans

Many biological and physical systems exhibit population-density dependent transitions to synchronized oscillations in a process often termed "dynamical quorum sensing". Synchronization frequently arises through chemical communication via…

Cell Behavior · Quantitative Biology 2010-12-23 David J. Schwab , Ania Baetica , Pankaj Mehta

Microbial communities play a significant role in bioremediation,plant growth,human and animal digestion,global elemental cycles including the carbon-cycle,and water treatment.They are also posed to be the engines of renewable energy via…

Emerging Technologies · Computer Science 2016-01-12 Nicolò Michelusi , James Boedicker , Mohamed Y. El-Naggar , Urbashi Mitra

Bacteria generally live in complicated structures called biofilms, consisting of communicating bacterial colonies and extracellular polymeric substance (EPS). Since biofilms are related to detrimental effects such as infection or antibiotic…

Quantitative Methods · Quantitative Biology 2023-11-07 Fatih Gulec , Andrew W. Eckford
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