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We develop a minimal whole-heart model that describes cardiac electrical conduction and simulate a basic three-lead electrocardiogram (ECG). We compare our 3-lead ECG model with clinical data from a Norwegian athlete database. The results…

Tissues and Organs · Quantitative Biology 2025-06-26 João Olívia , Rui Dilão

Blunt traumatic aortic rupture is a heart injury that can occur in falls, automobile accidents, and sporting injuries involving impact to the thorax. Despite its severity and high morbidity rate, the research still does not provide a…

This Artificial left ventricle is based on a simple conic assumption shape for left ventricle where its motion is made by attached compressed elastic tubes to its walls which are regarded to electrical points at each nodal .This compressed…

Medical Physics · Physics 2014-08-05 Saeed Ranjbar , Tohid Emami Meybodi , Mahmood Emami Meybodi

Since myocardial fibers drive the electric signal propagation throughout the myocardium, accurately modeling their arrangement is essential for simulating heart electrophysiology (EP). Rule-Based-Methods (RBMs) represent a commonly used…

Does the complex processes of angiogenesis during organism development ultimately lead to a near optimal coronary vasculature in the organs of adult mammals? We examine this hypothesis using a powerful and universal method, built on…

Biological Physics · Physics 2016-01-18 Jonathan Keelan , Emma M. L. Chung , James P. Hague

Internal haemorrhage, often leading to cardio-vascular arrest happens to be one of the prime sources of high fatality rates in mammals. We propose a simplistic model of fluid flow to specify the location of the haemorrhagic spots, which, if…

Soft Condensed Matter · Physics 2013-04-01 Amit K. Chattopadhyay , Shreekantha Sil

Objective: Exploit accelerometry data for an automatic, reliable, and prompt detection of spontaneous circulation during cardiac arrest, as this is both vital for patient survival and practically challenging. Methods: We developed a machine…

Signal Processing · Electrical Eng. & Systems 2023-02-13 Wolfgang J. Kern , Simon Orlob , Andreas Bohn , Wolfgang Toller , Jan Wnent , Jan-Thorsten Gräsner , Martin Holler

Mathematical models of the human heart are increasingly playing a vital role in understanding the working mechanisms of the heart, both under healthy functioning and during disease. The aim is to aid medical practitioners diagnose and treat…

Numerical Analysis · Mathematics 2023-11-13 Sridhar Chellappa , Barış Cansız , Lihong Feng , Peter Benner , Michael Kaliske

Our evolving understanding of the heterocellular cardiac environment demands innovative tools for its study. While murine models are lauded for their versatility and accessibility, they are constrained by scale; tools designed for larger…

Biological Physics · Physics 2023-12-12 Gavin Tumlinson , Enaam Chleilat , Josef Madl , Peter Kohl , Viviane Timmermann

Cardiovascular disease affects millions of people worldwide and its social and economic cost clearly motivates scientific research. Computer simulation can lead to a better understanding of cardiac physiology, and for pathology presents…

Biological Physics · Physics 2023-02-27 Toby Simpson

The asymmetry of coupling between complex systems can be studied by conditional probabilities of recurrence, which can be estimated by joint recurrence plots. This approach is applied for the first time on experimental data: time series of…

Chaotic Dynamics · Physics 2013-06-05 Norbert Marwan , Yong Zou , Niels Wessel , Maik Riedl , Jürgen Kurths

In this work, we develop patient-specific cardiocirculatory models with the aim of building Digital Twins for hypertension. In particular, in our pathophysiology-based framework, we consider both 0D cardiocirculatory models and a 3D-0D…

Numerical Analysis · Mathematics 2025-11-27 Simone Celora , Andrea Tonini , Francesco Regazzoni , Luca Dede' , Gianfranco Parati , Alfio Quarteroni

Hybrid modeling, the combination of first principle and machine learning models, is an emerging research field that gathers more and more attention. Even if hybrid models produce formidable results for academic examples, there are still…

Machine Learning · Computer Science 2021-12-15 Tobias Thummerer , Johannes Tintenherr , Lars Mikelsons

Many numerical studies of blood flow impose a rigid wall assumption due to the simplicity of its implementation compared to a full coupling to a solid mechanics model. In this paper, we present a localised method for incorporating the…

Fluid Dynamics · Physics 2021-08-20 J. W. S. McCullough , P. V. Coveney

Cardiopulmonary resuscitation (CPR) is an emergency procedure performed on patients during cardiac and respiratory arrest. This procedure externally activates the cardiac and respiratory systems via the delivery of chest compression and…

Numerical Analysis · Mathematics 2022-06-01 Jafar Moradicheghamahi , Gerard Fortuny , Josep M. López , Joan Herrero , Dolors Puigjaner

This work considers electrical impedance tomography imaging of the human head, with the ultimate goal of locating and classifying a stroke in emergency care. One of the main difficulties in the envisioned application is that the electrode…

Numerical Analysis · Mathematics 2021-12-08 Valentina Candiani , Nuutti Hyvönen , Jari P. Kaipio , Ville Kolehmainen

Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic responses.realize such advanced applications methodological key…

A numerical method to calculate optical conductivity based on a pump-probe setup is presented. Its validity and limits are tested and demonstrated via the concrete numerical simulations on the half-filled one-dimensional extended Hubbard…

Strongly Correlated Electrons · Physics 2016-05-26 Can Shao , Takami Tohyama , Hong-Gang Luo , Hantao Lu

This work proposes a methodology combining distributed and lumped models to simulate the current distribution in an indirect heat resistance furnace and, in particular, to compute the current to be supplied in order to obtain a desired…

Analysis of PDEs · Mathematics 2024-02-29 A. Bermúdez , D. Gómez , D. González-Peñas

Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Rene Lisasi , Michele Esposito , Chen Zhao