Our evolving understanding of the heterocellular cardiac environment demands innovative tools for its study. While murine models are lauded for their versatility and accessibility, they are constrained by scale; tools designed for larger subjects are unsuitable in mice. Advanced techniques, such as optical trans-membrane potential mapping and three-dimensional microscopy may fill this void. To enhance the utility of these methods, we developed a novel cross-correlation technique grounded in quaternion mathematics. The successful integration of multimodal observations represents a significant advancement in our ability to study cardiac electrophysiology in murine models, providing insight into mechanisms previously unexplored due to technical constraints.
@article{arxiv.2312.02922,
title = {Quaternion-Aligned Electroanatomical Models of the Murine Atria from Standard-Output Functional and Structural Imaging},
author = {Gavin Tumlinson and Enaam Chleilat and Josef Madl and Peter Kohl and Viviane Timmermann},
journal= {arXiv preprint arXiv:2312.02922},
year = {2023}
}