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Causal discovery for both cross-sectional and temporal data has traditionally followed a dataset-specific paradigm, where a new model is fitted for each individual dataset. Such an approach limits the potential of multi-dataset pretraining.…

Machine Learning (ML) has offered innovative perspectives for accelerating the discovery of new functional materials, leveraging the increasing availability of material databases. Despite the promising advances, data-driven methods face…

Early detection of dementia is crucial to devise effective interventions. Comprehensive cognitive tests, while being the most accurate means of diagnosis, are long and tedious, thus limiting their applicability to a large population,…

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In recent years, deep learning methods have achieved great success in various fields due to their strong performance in practical applications. In this paper, we present a light-weight neural network for Parkinson's disease diagnostics, in…

Traditional Chinese medicine (TCM) has relied on specific combinations of herbs in prescriptions to treat various symptoms and signs for thousands of years. Predicting TCM prescriptions poses a fascinating technical challenge with…

Computation and Language · Computer Science 2024-12-13 Xingzhi Zhou , Xin Dong , Chunhao Li , Yuning Bai , Yulong Xu , Ka Chun Cheung , Simon See , Xinpeng Song , Runshun Zhang , Xuezhong Zhou , Nevin L. Zhang

A key output of network meta-analysis (NMA) is the relative ranking of treatments; nevertheless, it has attracted substantial criticism. Existing ranking methods often lack clear interpretability and fail to adequately account for…

Domain-specific LLMs in TCM face limitations in research settings due to constrained adaptability, insufficient evaluation datasets, and limited computational resources. This study presents TianHui, a specialized TCM LLM built through…

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This paper establishes fundamental results for statistical inference of diagnostic classification models (DCM). The results are developed at a high level of generality, applicable to essentially all diagnostic classification models. In…

Statistics Theory · Mathematics 2025-01-08 Guanhua Fang , Jingchen Liu , Zhiliang Ying

In a real-life setting, little is known regarding the effectiveness of statins for primary prevention among older adults, and analysis of observational data can add crucial information on the benefits of actual patterns of use. Latent class…

Methodology · Statistics 2023-10-18 Awa Diop , Caroline Sirois , Jason Robert Guertin , Denis Talbot

Cognitive Diagnosis Models (CDMs) are a special family of discrete latent variable models that are widely used in modern educational, psychological, social and biological sciences. A key component of CDMs is a binary $Q$-matrix…

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Standard models assign disease progression to discrete categories or stages based on well-characterized clinical markers. However, such a system is potentially at odds with our understanding of the underlying biology, which in highly…

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Parkinson's disease (PD) is a neurological disorder requiring early and accurate diagnosis for effective management. Machine learning (ML) has emerged as a powerful tool to enhance PD classification and diagnostic accuracy, particularly by…

Process data, temporally ordered categorical observations, are of recent interest due to its increasing abundance and the desire to extract useful information. A process is a collection of time-stamped events of different types, recording…

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Large language models (LLMs) are advancing rapidly in medical NLP, yet Traditional Chinese Medicine (TCM) with its distinctive ontology, terminology, and reasoning patterns requires domain-faithful evaluation. Existing TCM benchmarks are…

Traditional Chinese Medicine (TCM) has accumulated a big amount of precious resource in the long history of development. TCM prescriptions that consist of TCM herbs are an important form of TCM treatment, which are similar to natural…

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Causal discovery from observational data is fundamental to scientific fields like biology, where controlled experiments are often impractical. However, existing methods, including constraint-based (e.g., PC, causalMGM) and score-based…

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Diagnosis of hematological malignancies depends on accurate identification of white blood cells in peripheral blood smears. Deep learning techniques are emerging as a viable solution to scale and optimize this process by automatic cell…

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Diabetes is a major health problem in both developing and developed countries and its incidence is rising dramatically. In this study, we investigate a novel automatic approach to diagnose Diabetes disease based on Feature Weighted Support…

Machine Learning · Computer Science 2012-01-12 Davar Giveki , Hamid Salimi , GholamReza Bahmanyar , Younes Khademian

High-throughput microarray and sequencing technology have been used to identify disease subtypes that could not be observed otherwise by using clinical variables alone. The classical unsupervised clustering strategy concerns primarily the…

Methodology · Statistics 2020-07-23 Peng Liu , Yusi Fang , Zhao Ren , Lu Tang , George C. Tseng

Missing data is a major challenge in clinical research. In electronic medical records, often a large fraction of the values in laboratory tests and vital signs are missing. The missingness can lead to biased estimates and limit our ability…

Machine Learning · Computer Science 2023-04-18 Omer Noy , Ron Shamir