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Dynamic treatment regimes (DTRs) are used in medicine to tailor sequential treatment decisions to patients by considering patient heterogeneity. Common methods for learning optimal DTRs, however, have shortcomings: they are typically based…
Recent advancements in Large Language Models (LLMs) have positioned them as powerful tools for clinical decision-making, with rapidly expanding applications in healthcare. However, concerns about bias remain a significant challenge in the…
Access to real-world healthcare data is limited by stringent privacy regulations and data imbalances, hindering advancements in research and clinical applications. Synthetic data presents a promising solution, yet existing methods often…
We propose a categorical matrix factorization method to infer latent diseases from electronic health records (EHR) data in an unsupervised manner. A latent disease is defined as an unknown biological aberration that causes a set of common…
Phenotyping is the process of distinguishing groups of patients to identify different types of disease progression. A recent trend employs low-rank matrix and tensor factorization methods for their capability of dealing with multi-modal,…
Fundamental knowledge in activity recognition of individuals with motor disorders such as Parkinson's disease (PD) has been primarily limited to detection of steady-state/static tasks (sitting, standing, walking). To date, identification of…
In this paper, we propose a new variant of Linear Discriminant Analysis (LDA) to solve multi-label classification tasks. The proposed method is based on a probabilistic model for defining the weights of individual samples in a weighted…
Temporal anomaly detection looks for irregularities over space-time. Unsupervised temporal models employed thus far typically work on sequences of feature vectors, and much less on temporal multiway data. We focus our investigation on…
After performing comparison of the performance of seven different machine learning models on detection depression tasks to show that the choice of features is essential, we compare our methods and results with the published work of other…
Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose…
Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…
Diagnostic processes for complex cyber-physical systems often require extensive prior knowledge in the form of detailed system models or comprehensive training data. However, obtaining such information poses a significant challenge. To…
Driven by the dual principles of smart education and artificial intelligence technology, the online education model has rapidly emerged as an important component of the education industry. Cognitive diagnostic technology can utilize…
Medical image segmentation is a fundamental task in numerous medical engineering applications. Recently, language-guided segmentation has shown promise in medical scenarios where textual clinical reports are readily available as semantic…
Mental disorders are clinically significant patterns of behavior that are associated with stress and/or impairment in social, occupational, or family activities. People suffering from such disorders are often misjudged and poorly diagnosed…
Traditional Chinese Medicine theory is built on imagistic thinking, in which medical principles and diagnostic and therapeutic logic are structured through metaphor and metonymy. However, existing English translations largely rely on…
Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking…
Melanoma is a type of skin cancer developed from melanocytes. It is one of the most lethal types of cancer, accounting for approximately 75% of skin cancer deaths. Late stage melanoma is very difficult to treat, since the cancer cells are…
Metabolic disorders, particularly type 2 diabetes mellitus (T2DM), represent a significant global health burden, disproportionately impacting genetically predisposed populations such as the Pima Indians (a Native American tribe from south…
Unsupervised learning aims at the discovery of hidden structure that drives the observations in the real world. It is essential for success in modern machine learning. Latent variable models are versatile in unsupervised learning and have…