Related papers: Bifurcation in cell cycle dynamics regulated by p5…
Cells with the same genome can exist in different phenotypes. and can change between distinct phenotypes when subject to specific stimuli and microenvironments. Some examples include cell differentiation during development, reprogramming…
Cells achieve size homeostasis by regulating their division timing based on their size, added size, and cell cycle time. Previous research under steady-state conditions demonstrated the robustness of these mechanisms. However, their dynamic…
The slow passage through a Hopf bifurcation leads to the delayed appearance of large amplitude oscillations. We construct a smooth scalar feedback control which suppresses the delay and causes the system to follow a stable equilibrium…
In this paper we use a continuous model to describe the development of a single cell lineage following the committal of stem cells. Three separate controls are implemented in the model, namely the proliferative control of stem cells, the…
Oscillatory systems with time-delayed pulsatile feedback appear in various applied and theoretical research areas, and received a growing interest in the last years. For such systems, we report a remarkable scenario of destabilization of a…
The classical Hodgkin--Huxley (HH) model neglects the time-dependence of ion concentrations in spiking dynamics. The dynamics is therefore limited to a time scale of milliseconds, which is determined by the membrane capacitance multiplied…
We study analytically and numerically a model metabolic cycle composed of an arbitrary number of species of catalytically active particles. Each species converts a substrate into a product, the latter being used as the substrate by the next…
Signaling molecules play an important role for many cellular functions. We investigate here a general system of two membrane reaction-diffusion equations coupled to a diffusion equation inside the cell by a Robin-type boundary condition and…
In this article is shown that large systems endowing phase coexistence display self-oscillations in presence of linear feedback between the control and order parameters, where an Andronov-Hopf bifurcation takes over the phase transition.…
Based on symmetry consideration of migration and shape deformations, we formulate phenomenologically the dynamics of cell crawling in two dimensions. Forces are introduced to change the cell shape. The shape deformations induce migration of…
A ubiquitous way that cells share information is by exchanging molecules. Yet, the fundamental ways that this information exchange is influenced by intracellular dynamics remain unclear. Here we use information theory to investigate a…
Differential equation-based physiological models of sleep-wake networks describe sleep-wake regulation by simulating the activity of wake- and sleep-promoting neuronal populations and the modulation of these populations by homeostatic and…
Biological cells encode information about their environment through biochemical signaling networks that control their internal state and response. This information is often encoded in the dynamical patterns of the signaling molecules,…
Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential…
A dynamic model for cell differentiation is studied, where cells with internal chemical reaction dynamics interact with each other and replicate. It leads to spontaneous differentiation of cells and determination, as is discussed in the…
Distributed delays modeled by 'weak generic kernels' are introduced in the well-known coupled Landau-Stuart system, as well as a chaotic van der Pol-Rayleigh system with parametric forcing. The systems are close via the 'linear chain…
Triadic interactions are special types of higher-order interactions that occur when regulator nodes modulate the interactions between other two or more nodes. In presence of triadic interactions, a percolation process occurring on a…
Signal duration (e.g. the time scales over which an active signaling intermediate persists) is a key regulator of biological decisions in myriad contexts such as cell growth, proliferation, and developmental lineage commitments.…
We rigorously show that a class of systems of partial differential equations modeling wave bifurcations supports stationary equivariant bifurcation dynamics through deriving its full dynamics on the center manifold(s). A direct consequence…
The bifurcation structure of coupled periodically driven double-well Duffing oscillators is investigated as a function of the strength of the driving force $f$ and its frequency $\Omega$. We first examine the stability of the steady state…