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We address the problem of proteasomal protein translocation and introduce a new stochastic model of the proteasomal digestion (cleavage) of proteins. In this model we account for the protein translocation and the positioning of cleavage…

Other Quantitative Biology · Quantitative Biology 2008-07-28 D. S. Goldobin , M. Mishto , K. Textoris-Taube , P. M. Kloetzel , A. Zaikin

Hydrogen cations, or protons, provide the medium by which energy is stored and converted in biological systems. Such pre-eminence relies on the interplay between interfacial and bulk chemical transformations, according to mechanisms that…

Subcellular Processes · Quantitative Biology 2026-05-26 Luca Quaroni

MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

Biomolecules · Quantitative Biology 2018-04-18 David Menéndez Hurtado , Karolis Uziela , Arne Elofsson

Post-transductional modifications tune the functions of proteins and regulate the collective dynamics of biochemical networks that determine how cells respond to environmental signals. For example, protein phosphorylation and nitrosylation…

Cell Behavior · Quantitative Biology 2009-11-13 Roberto Chignola , Chiara Dalla Pellegrina , Alessio Del Fabbro , Edoardo Milotti

Understanding energy dissipation and transport in nanoscale structures is of great importance for the design of energy-efficient circuits and energy-conversion systems. This is also a rich domain for fundamental discoveries at the…

Mesoscale and Nanoscale Physics · Physics 2010-03-23 Eric Pop

Predicting protein functional characteristics from structure remains a central problem in protein science, with broad implications from understanding the mechanisms of disease to designing novel therapeutics. Unfortunately, current machine…

Biological Physics · Physics 2024-09-30 Kevin Borisiak , Gian Marco Visani , Armita Nourmohammad

We investigate the transport of proteins inside the proteasome and propose an active transport mechanism based on a spatially asymmetric interaction potential of peptide chains. The transport is driven by fluctuations which are always…

Biomolecules · Quantitative Biology 2007-05-23 Alexei Zaikin , Thorsten Poeschel

Neither of the two prevalent theories, namely thermodynamic stability and kinetic stability, provides a comprehensive understanding of protein folding. The thermodynamic theory is misleading because it assumes that free energy is the…

Biological Physics · Physics 2013-07-22 Ji Xu , Mengzhi Han , Ying Ren , Jinghai Li

Predicting structural and energetic properties of a molecular system is one of the fundamental tasks in molecular simulations, and it has use cases in chemistry, biology, and medicine. In the past decade, the advent of machine learning…

Chemical Physics · Physics 2022-08-23 Sajjad Heydari , Stefano Raniolo , Lorenzo Livi , Vittorio Limongelli

When a system is in equilibrium, external perturbations yield a time series of non-equilibrium distributions, and recent experimental techniques give access to the non-equilibrium data that may contain critical information. Jinwoo and…

Statistical Mechanics · Physics 2023-01-16 Lee Jinwoo

The theory of biochemical processes needs simple but realistic models of phenomena underlying microscopic dynamics of proteins. Many experiments performed in the 1980s have demonstrated that within the protein native state, apart from usual…

Condensed Matter · Physics 2007-05-23 Michal Kurzynski

Biological systems are known to communicate by diffusing chemical signals in the surrounding medium. However, most of the recent literature has neglected the electron transfer mechanism occurring amongst living cells, and its role in…

Emerging Technologies · Computer Science 2015-02-23 Nicolo Michelusi , Sahand Pirbadian , Mohamed Y. El-Naggar , Urbashi Mitra

The guiding and transport of energy, for example of electromagnetic waves underpins many technologies that have shaped modern society, ranging from long distance optical fibre telecommunications to on-chip optical processors. Traditionally,…

Wireless power transfer (WPT) has garnered increasing attention due to its potential to eliminate device-side batteries. With the advent of (distributed) multiple-input multiple-output (MIMO), radio frequency (RF) WPT has become feasible…

Signal Processing · Electrical Eng. & Systems 2024-08-21 Gilles Callebaut , Jarne Van Mulders , Bert Cox , Liesbet Van der Perre , Lieven De Strycker , François Rottenberg

Charge transfer is a fundamental process that underlies a multitude of phenomena in chemistry and biology. Recent advances in observing and manipulating charge and heat transport at the nanoscale, and recently developed techniques for…

Mesoscale and Nanoscale Physics · Physics 2016-07-26 Galen T. Craven , Abraham Nitzan

We study a linear chain of oscillators with inhomogeneity in their interactions with phonon bath. In a previous work on the Markovian master equation of the system, we investigated a model in which the difference in the site-phonon coupling…

Statistical Mechanics · Physics 2022-05-18 B. A. Tay

Power supply for small-scale battery-powered systems such as electric vehicles (EVs and mobile robots) is being actively researched. We are particularly interested in energy management, which considers the interconnection of such systems…

Systems and Control · Electrical Eng. & Systems 2024-10-28 Takahiro Mamiya , Shiu Mochiyama , Takashi Hikihara

Recent observations of beating signals in the excitation energy transfer dynamics of photosynthetic complexes have been interpreted as evidence for sustained coherences that are sufficiently long-lived for energy transport and coherence to…

Quantum Physics · Physics 2013-03-05 A. W. Chin , J. Prior , R. Rosenbach , F. Caycedo-Soler , S. F. Huelga , M. B. Plenio

We perform simulations to investigate how the energy carried by a molecule transfers to others in an equilibrium gas model. For this purpose we consider a microcanonical ensemble of equilibrium gas systems, each of them contains a tagged…

Classical Physics · Physics 2015-05-27 Jinghua Yang , Yong Zhang , Jiao Wang , Hong Zhao

Following the ideas of Davydov's soliton theory, we study the bio-energy transport in protein molecules. By using a quantum Brownian motion model for a phonon dressed vibrational exciton, we calculate the time-dependence on the mean square…

Biological Physics · Physics 2019-04-01 Theja N. De Silva , Peighton Bolt
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