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An interferometric fluorescent microscope and a novel theoretic image reconstruction approach were developed and used to obtain super-resolution images of live biological samples and to enable dynamic real time tracking. The tracking…

A backside-illuminated (BSI) near-infrared enhanced silicon single-photon avalanche diode (SPAD) for time-of-flight (ToF) light detection and ranging applications is presented. The detector contains a 2 $\mu$m wide multiplication region…

Instrumentation and Detectors · Physics 2022-03-04 Edward Van Sieleghem , Gauri Karve , Koen De Munck , Andrea Vinci , Celso Cavaco , Andreas Süss , Chris Van Hoof , Jiwon Lee

We show, both theoretically and experimentally, that high-numerical-aperture (NA) optical microscopy is accompanied by strong spin-orbit interaction of light, which translates fine infomation about the specimen to the polarization degrees…

Super-resolution imaging methods that combine interferometric (z) analysis with single-molecule localization microscopy (iSMLM) have achieved ultra-high 3D precision and contributed to the elucidation of important biological…

Optics · Physics 2025-02-20 Wei Wang , Zengxin Huang , Yilin Wang , Hangfeng Li , Pakorn Kanchanawong

In the design of optical devices and components, geometric structures and optical properties of materials, such as absorption, refraction, reflection, diffraction, scattering, and trapping, have been utilized. Finding the ideal material…

A novel non-invasive microscopy technique for imaging and sizing of folded DNA molecules with the use of photovoltaic tweezers and phase-sensitive detection is elaborated and realized. This novel method is compared with the state-of-the-art…

Atomic Physics · Physics 2025-02-27 Lusine Tsarukyan , Anahit Badalyan , Rafael Drampyan

The center-of-mass motion of optically trapped dielectric nanoparticles in vacuum is extremely well-decoupled from its environment, making a powerful tool for measurements of feeble sub-attonewton forces. We demonstrate a method to trap and…

I propose a spatial-mode demultiplexing (SPADE) measurement scheme for the far-field imaging of spatially incoherent optical sources. For any object too small to be resolved by direct imaging under the diffraction limit, I show that SPADE…

Optics · Physics 2017-03-01 Mankei Tsang

Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However,…

Tissues and Organs · Quantitative Biology 2016-08-10 Avinoam Bar-Zion , Charles Tremblay-Darveau , Oren Solomon , Dan Adam , Yonina C. Eldar

Single fluorescent molecules, behaving as ideal electric dipole emitters, are powerful nanoscopic probes of complex optical fields. Here, this property is exploited to precisely map the polarization and vectorial structure of tightly…

We propose a novel technique of microscopy to overcome the effects of both scattering and limitation of the accessible depth due to the objective working distance. By combining Laser Optical Feedback Imaging (LOFI) with Acoustic Photon…

Multicolor super-resolution imaging remains an intractable challenge for both far-field and near-field based super-resolution techniques. Planar super-oscillatory lens (SOL), a far-field subwavelength-focusing diffractive lens device, holds…

Optical tweezers is a very well-established technique that has developed into a standard tool for trapping and manipulating micron and submicron particles with great success in the last decades. Although the nature of light enforces…

Optics · Physics 2020-01-22 Theodoros D. Bouloumis , Sile Nic Chormaic

Optical responsivity grants biomedical capsules additional capabilities, promoting them towards multifunctional theragnostic nanodevices. In this endeavor, screening candidates under conditions that closely resemble in situ environments is…

Optical nanoscopy is crucial in life and materials sciences, revealing subtle cellular processes and nanomaterial properties. Scattering-type Scanning Near-field Optical Microscopy (s-SNOM) provides nanoscale resolution, relying on the…

Understanding the nanoscale carrier dynamics induced by light excitation is the key to unlocking futuristic devices and innovative functionalities in advanced materials. Optical pump-probe scanning tunneling microscopy (OPP-STM) has opened…

Materials Science · Physics 2024-03-28 Katsuya Iwaya , Hiroyuki Mogi , Shoji Yoshida , Yusuke Arashida , Osamu Takeuchi , Hidemi Shigekawa

We present a detailed theoretical study of the recent proposal for selective nanomanipulation of nanometric particles above a substrate using near-field optical forces [Chaumet {\it et al.} Phys. Rev. Lett. {\bf 88}, 123601 (2002)].…

Optics · Physics 2009-11-10 Patrick C. Chaumet , Adel Rahmani , Manuel Nieto-Vesperinas

Near-field patterns of light provide a way to optically trap, deliver and sort single nanoscopic particles in a wide variety of applications in nanophotonics, microbiology and nanotechnology. Using rigorous electromagnetic theory, we…

Optics · Physics 2022-06-01 Edgar Alonso Guzmán , Alejandro V. Arzola

Achieving high spatial resolution is the goal of many imaging systems. Designing a high-resolution lens with diffraction-limited performance over a large field of view remains a difficult task in imaging system design. On the other hand,…

Fixing a diamond containing a high density of Nitrogen-Vacancy (NV) center ensembles on the apex of a multimode optical fiber (MMF) extends the applications of NV-based endoscope sensors. Replacing the normal MMF with a tapered MMF…