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We investigate how classifiers for Boolean networks (BNs) can be constructed and modified under constraints. A typical constraint is to observe only states in attractors or even more specifically steady states of BNs. Steady states of BNs…

Commutative Algebra · Mathematics 2021-08-20 Robert Schwieger , Matías R. Bender , Heike Siebert , Christian Haase

This paper studies the controllability of networked multi-input-multi-output (MIMO) systems, in which the network topology is weighted and directed, and the nodes are heterogeneous higher-dimensional linear time-invariant (LTI) dynamical…

Optimization and Control · Mathematics 2020-06-23 Linying Xiang , Peiru Wang , Fei Chen , Guanrong Chen

Using Boolean networks as prototypical examples, the role of symmetry in the dynamics of heterogeneous complex systems is explored. We show that symmetry of the dynamics, especially in critical states, is a controlling feature that can be…

Statistical Mechanics · Physics 2015-06-19 Shabnam Hossein , Matthew D. Reichl , Kevin E. Bassler

Random Boolean networks, originally invented as models of genetic regulatory networks, are simple models for a broad class of complex systems that show rich dynamical structures. From a biological perspective, the most interesting networks…

Disordered Systems and Neural Networks · Physics 2009-11-07 Joshua E. S. Socolar , Stuart A. Kauffman

In this paper, a deep reinforcement learning based method is proposed to obtain optimal policies for optimal infinite-horizon control of probabilistic Boolean control networks (PBCNs). Compared with the existing literatures, the proposed…

Systems and Control · Electrical Eng. & Systems 2023-04-10 Jingjie Ni , Fangfei Li , Zheng-Guang Wu

Boolean networks are dynamical models of disease development in which the activation levels of genes are represented by binary variables. Given a Boolean network, controls represent mutations or medical treatments that fix the activation…

Optimization and Control · Mathematics 2026-04-02 Kyungduk Moon , Kangbok Lee , Loïc Paulevé

We performed a numerical study on random Boolean networks with power-law rank outdegree distributions to find local structural cause for the emergence of high or low degree of coherence in binary state variables. The degree of randomness…

Cellular Automata and Lattice Gases · Physics 2007-07-02 Chikoo Oosawa , Kazuhiro Takemoto , Shogo Matsumoto , Michael A. Savageau

To meet ongoing cognitive demands, the human brain must seamlessly transition from one brain state to another, in the process drawing on different cognitive systems. How does the brain's network of anatomical connections help facilitate…

Neurons and Cognition · Quantitative Biology 2016-09-08 Richard F. Betzel , Shi Gu , John D. Medaglia , Fabio Pasqualetti , Danielle S. Bassett

The dynamics of noise-resilient Boolean networks with majority functions and diverse topologies is investigated. A wide class of possible topological configurations is parametrized as a stochastic blockmodel. For this class of networks, the…

Disordered Systems and Neural Networks · Physics 2012-01-11 Tiago P. Peixoto

The control of complex systems is an ongoing challenge of complexity research. Recent advances using concepts of structural control deduce a wide range of control related properties from the network representation of complex systems. Here,…

Statistical Mechanics · Physics 2013-12-31 Márton Pósfai , Philipp Hövel

Fixed points are fundamental states in any dynamical system. In the case of gene regulatory networks (GRNs) they correspond to stable genes profiles associated to the various cell types. We use Kauffman's approach to model GRNs with random…

Cell Behavior · Quantitative Biology 2012-03-08 Pablo Moisset de Espanés , Axel Osses , Iván Rapaport

A Boolean network (BN) with $n$ components is a discrete dynamical system described by the successive iterations of a function $f:\{0,1\}^n \to \{0,1\}^n$. This model finds applications in biology, where fixed points play a central role.…

Combinatorics · Mathematics 2022-02-10 Florian Bridoux , Amélia Durbec , Kévin Perrot , Adrien Richard

In this paper, we develop a notion of controllability for hypergraphs via tensor algebra and polynomial control theory. Inspired by uniform hypergraphs, we propose a new tensor-based multilinear dynamical system representation, and derive a…

Optimization and Control · Mathematics 2021-03-25 Can Chen , Amit Surana , Anthony Bloch , Indika Rajapakse

Boolean threshold networks have recently been proposed as useful tools to model the dynamics of genetic regulatory networks, and have been successfully applied to describe the cell cycles of \textit{S. cerevisiae} and \textit{S. pombe}.…

Chaotic Dynamics · Physics 2010-11-18 Jorge G. T. Zañudo , Maximino Aldana , Gustavo Martínez-Mekler

The control of biological systems presents interesting applications such as cell reprogramming or drug target identification. A common type of control strategy consists in a set of interventions that, by fixing the values of some variables,…

Molecular Networks · Quantitative Biology 2021-12-21 Laura Cifuentes Fontanals , Elisa Tonello , Heike Siebert

Controllability of complex networks arises in many technological problems involving social, financial, road, communication, and smart grid networks. In many practical situations, the underlying topology might change randomly with time, due…

Systems and Control · Computer Science 2020-01-08 Fernando Gama , Elvin Isufi , Alejandro Ribeiro , Geert Leus

Boolean networks can be viewed as functions on the set of binary strings of a given length, described via logical rules. They were introduced as dynamic models into biology, in particular as logical models of intracellular regulatory…

Dynamical Systems · Mathematics 2025-04-16 J. García Galofre , M. Pérez Millán , A. Galarza Rial , R. Laubenbacher , A. Dickenstein

A Boolean network is a mapping $f :\{0,1\}^n \to \{0,1\}^n$, which can be used to model networks of $n$ interacting entities, each having a local Boolean state that evolves over time according to a deterministic function of the current…

Combinatorics · Mathematics 2021-04-29 Maximilien Gadouleau

In this paper we explore how non trivial boundary conditions could influence the entanglement entropy in a topological order in 2+1 dimensions. Specifically we consider the special class of topological orders describable by the quantum…

High Energy Physics - Theory · Physics 2018-06-26 Chaoyi Chen , Ling-Yan Hung , Yingcheng Li , Yidun Wan

This paper studies the minimum control node set problem for Boolean networks (BNs) with degree constraints. The main contribution is to derive the nontrivial lower and upper bounds on the size of the minimum control node set through…

Systems and Control · Electrical Eng. & Systems 2026-03-03 Liangjie Sun , Wai-Ki Ching , Tatsuya Akutsu
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