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Protein structure tokenization converts 3D structures into discrete or vectorized representations, enabling the integration of structural and sequence data. Despite many recent works on structure tokenization, the properties of the…

Machine Learning · Computer Science 2025-11-14 Zijing Liu , Bin Feng , He Cao , Yu Li

Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the…

Quantitative Methods · Quantitative Biology 2024-08-14 Kamyar Zeinalipour , Neda Jamshidi , Monica Bianchini , Marco Maggini , Marco Gori

Despite the high accuracy of 'black box' deep learning models, drug discovery still relies on protein-ligand interaction principles and heuristics. To improve interpretability of protein-small molecule binding predictions, we developed the…

Machine Learning · Computer Science 2026-04-21 Jingke Chen , Jingrui Zhong , Tazneen Hossain Tani , Zidong Su , Xiaochun Zhang , Boxue Tian

We propose a new approach to learn to segment multiple image objects without manual supervision. The method can extract objects form still images, but uses videos for supervision. While prior works have considered motion for segmentation, a…

Computer Vision and Pattern Recognition · Computer Science 2022-10-24 Laurynas Karazija , Subhabrata Choudhury , Iro Laina , Christian Rupprecht , Andrea Vedaldi

We revisit a self-supervised method that segments unlabelled speech into word-like segments. We start from the two-stage duration-penalised dynamic programming method that performs zero-resource segmentation without learning an explicit…

Audio and Speech Processing · Electrical Eng. & Systems 2024-02-01 Herman Kamper , Benjamin van Niekerk

Due to the absence of explicit word boundaries in the speech stream, the task of segmenting spoken sentences into word units without text supervision is particularly challenging. In this work, we leverage the most recent self-supervised…

Computation and Language · Computer Science 2023-10-10 Robin Algayres , Pablo Diego-Simon , Benoit Sagot , Emmanuel Dupoux

Classification of proteins based on their structure provides a valuable resource for studying protein structure, function and evolutionary relationships. With the rapidly increasing number of known protein structures, manual and…

Computational Engineering, Finance, and Science · Computer Science 2009-07-14 Oktie Hassanzadeh

Given usefulness of protein language models (LMs) in structure and functional inference, RNA LMs have received increased attentions in the last few years. However, these RNA models are often not compared against the same standard. Here, we…

Biomolecules · Quantitative Biology 2025-05-15 He Wang , Yikun Zhang , Jie Chen , Jian Zhan , Yaoqi Zhou

Word or word-fragment based Language Models (LM) are typically preferred over character-based ones in many downstream applications. This may not be surprising as words seem more linguistically relevant units than characters. Words provide…

Computation and Language · Computer Science 2022-10-07 Tu Anh Nguyen , Maureen de Seyssel , Robin Algayres , Patricia Roze , Ewan Dunbar , Emmanuel Dupoux

Unsupervised text segmentation is crucial because boundary labels are expensive, subjective, and often fail to transfer across domains and granularity choices. We propose Embed-KCPD, a training-free method that represents sentences as…

Computation and Language · Computer Science 2026-01-27 Mumin Jia , Jairo Diaz-Rodriguez

We study the problem of generating keyphrases that summarize the key points for a given document. While sequence-to-sequence (seq2seq) models have achieved remarkable performance on this task (Meng et al., 2017), model training often relies…

Computation and Language · Computer Science 2019-09-09 Hai Ye , Lu Wang

While many languages possess processes of joining two or more words to create compound words, previous studies have been typically limited only to languages with excessively productive compound formation (e.g., German, Dutch) and there is…

Computation and Language · Computer Science 2023-10-24 Benjamin Minixhofer , Jonas Pfeiffer , Ivan Vulić

In order to leverage and profit from unlabelled data, semi-supervised frameworks for semantic segmentation based on consistency training have been proven to be powerful tools to significantly improve the performance of purely supervised…

Computer Vision and Pattern Recognition · Computer Science 2021-12-09 Max Coenen , Tobias Schack , Dries Beyer , Christian Heipke , Michael Haist

We present two approaches that use unlabeled data to improve sequence learning with recurrent networks. The first approach is to predict what comes next in a sequence, which is a conventional language model in natural language processing.…

Machine Learning · Computer Science 2015-11-05 Andrew M. Dai , Quoc V. Le

Modern language models (LMs) are not robust to out-of-distribution inputs. Machine generated (``optimized'') prompts can be used to modulate LM outputs and induce specific behaviors while appearing completely uninterpretable. In this work,…

Computation and Language · Computer Science 2025-09-04 Rimon Melamed , Lucas H. McCabe , H. Howie Huang

For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

Machine Learning · Computer Science 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Terminology extraction, also known as term extraction, is a subtask of information extraction. The goal of terminology extraction is to extract relevant words or phrases from a given corpus automatically. This paper focuses on the…

Computation and Language · Computer Science 2021-01-25 Suman Dowlagar , Radhika Mamidi

Unsupervised cross-lingual pretraining has achieved strong results in neural machine translation (NMT), by drastically reducing the need for large parallel data. Most approaches adapt masked-language modeling (MLM) to sequence-to-sequence…

Computation and Language · Computer Science 2021-06-11 Christos Baziotis , Ivan Titov , Alexandra Birch , Barry Haddow

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…

Large Language Models (LLMs) have revolutionized the field of natural language processing, but they fall short in comprehending biological sequences such as proteins. To address this challenge, we propose InstructProtein, an innovative LLM…

Biomolecules · Quantitative Biology 2023-10-06 Zeyuan Wang , Qiang Zhang , Keyan Ding , Ming Qin , Xiang Zhuang , Xiaotong Li , Huajun Chen
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