Related papers: Dynamic Variation in Protein-Small Molecule Intera…
This study employs molecular dynamics simulations to examine the physisorption behavior of hydrocarbon molecules on a covalent graphene-nanotube hybrid nanostructure. The results indicate that the adsorbed molecules undergo self-diffusion…
Motor proteins are active enzyme molecules that play a crucial role in many biological processes. They transform the chemical energy into the mechanical work and move unidirectionally along rigid cytoskeleton filaments. Single-molecule…
Small molecules play a pivotal role in modern medicine, and scrutinizing their interactions with protein targets is essential for the discovery and development of novel, life-saving therapeutics. The term "bioactivity" encompasses various…
Gene regulation is one of the most important fundamental biological processes in living cells. It involves multiple protein molecules that locate specific sites on DNA and assemble gene initiation or gene repression multi-molecular…
Thermophoresis moves molecules along temperature gradients, typically from hot to cold. We superpose fluid flow with thermophoretic molecule flow under well defined microfluidic conditions, imaged by fluorescence microscopy. DNA is trapped…
The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interactions, binding partners are classically envisioned as finely…
We describe an approach to optically trapping small, chemically stable molecules at cryogenic temperatures by buffer-gas loading a deep optical dipole trap. The ~10 K trap depth will be produced by a tightly-focused, 1064-nm cavity capable…
Directional motion is commonly observed in various living active systems, such as bacterial colonies moving through confined environments. In these systems, the dynamics arise from the collective effects of mutual interactions between…
Introduced more than fifty years ago, dynamic light scattering is routinely used to determine the size distribution of colloidal suspensions, as well as of macromolecules in solution, such as proteins, nucleic acids, and their complexes.…
An analysis on the discrete versus continuous views of kinetics of macromolecules is presented. It is shown that the discrete approach traditional to biochemistry is insufficient for understanding the dynamics of protein molecules in…
RNA/protein interactions play crucial roles in controlling gene expression. They are becoming important targets for pharmaceutical applications. Due to RNA flexibility and to the strength of electrostatic interactions, standard docking…
Hypotheses: Additives are commonly used to tune macromolecular conformational transitions. Among additives, trehalose is an excellent bioprotectant and among responsive polymers, PNIPAM is the most studied material. Nevertheless, their…
Optical binding allows creation of mechanically stable nanoparticle configurations owing to formation of self-consistent optical trapping potentials. While the classical diffraction limit prevents achieving deeply subwavelength…
The increasing interest in photoactivated proteins as natural replacement of standard inorganic materials in photocells drives to the compared analysis of bacteriorhodopsin and proteorhodopsin, two widely diffused proteins belonging to the…
We experimentally demonstrate efficient interfacing of a large number of atoms to an optical nanofiber using an optical lattice with tunable spacing ($0.88-1.5~\mu$m) projected onto the nanofiber. The lattice beam and reflections from the…
We incorporate hydrodynamic interactions in a structure-based model of ubiquitin and demonstrate that the hydrodynamic coupling may reduce the peak force when stretching the protein at constant speed, especially at larger speeds.…
Understanding why some cellular components are conserved across species, while others evolve rapidly is a key question of modern biology. Here we demonstrate that in S. cerevisiae proteins organized in cohesive patterns of interactions are…
Proteins must fold quickly to acquire their biologically functional three-dimensional native structures. Hence, these are mainly stabilized by local contacts, while intricate topologies such as knots are rare. Here, we reveal the existence…
We investigate dynamics and interactions of particles levitated and trapped by the thermophoretic force in a vacuum cell. Our analysis is based on footage taken by orthogonal cameras that are able to capture the three dimensional…
This paper presents the most complete framework to date for understanding the nonlinear optical trapping of highly absorbing nanoparticles within the dipole regime. Highly absorbing and plasmonic particles garner considerable interest due…