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Digitization, i.e., the process of converting information into a digital format, may provide various opportunities (e.g., increase in productivity, disaster recovery, and environmentally friendly solutions) and challenges for businesses. In…

Computer Vision and Pattern Recognition · Computer Science 2021-06-09 Nouna Khandan

Current metagenomic analysis algorithms require significant computing resources, can report excessive false positives (type I errors), may miss organisms (type II errors / false negatives), or scale poorly on large datasets. This paper…

Databases · Computer Science 2015-01-23 Ashley Mae Conard , Stephanie Dodson , Jeremy Kepner , Darrell Ricke

Post-training of Large Language Models (LLMs) is crucial for unlocking their task generalization potential and domain-specific capabilities. However, the current LLM post-training paradigm faces significant data challenges, including the…

Computation and Language · Computer Science 2025-10-31 Junyu Luo , Bohan Wu , Xiao Luo , Zhiping Xiao , Yiqiao Jin , Rong-Cheng Tu , Nan Yin , Yifan Wang , Jingyang Yuan , Wei Ju , Ming Zhang

Determining the localization of specific protein in human cells is important for understanding cellular functions and biological processes of underlying diseases. Among imaging techniques, high-throughput fluorescence microscopy imaging is…

Computer Vision and Pattern Recognition · Computer Science 2019-02-01 Yijun Tian

Determining the interaction strength between proteins and small molecules is key to analyzing their biological function. Quantum-mechanical calculations such as \emph{Density Functional Theory} (DFT) give accurate and theoretically…

Data Structures and Algorithms · Computer Science 2016-06-13 Moritz von Looz , Mario Wolter , Christoph R. Jacob , Henning Meyerhenke

Grid computing is the next logical step to distributed computing. Main objective of grid computing is an innovative approach to share resources such as CPU usage; memory sharing and software sharing. Data Grids provide transparent access to…

Distributed, Parallel, and Cluster Computing · Computer Science 2010-03-23 S. Vidhya , S. Karthikeyan

Traditional clustering methods are limited when dealing with huge and heterogeneous groups of gene expression data, which motivates the development of bi-clustering methods. Bi-clustering methods are used to mine bi-clusters whose subsets…

Computer Vision and Pattern Recognition · Computer Science 2020-05-13 Kaijie Xu , Witold Pedrycz , Zhiwu Li , Yinghui Quan , Weike Nie

BACKGROUND: One of the most evident achievements of bioinformatics is the development of methods that transfer biological knowledge from characterised proteins to uncharacterised sequences. This mode of protein function assignment is mostly…

Quantitative Methods · Quantitative Biology 2007-09-28 Emmanuel D. Levy , Christos A. Ouzounis , Walter R. Gilks , Benjamin Audit

Now a day's students have a large set of data having precious information hidden. Data mining technique can help to find this hidden information. In this paper, data mining techniques name Byes classification method is used on these data to…

Databases · Computer Science 2012-03-26 Umesh Kumar Pandey , Saurabh Pal

Protein function is inherently linked to its localization within the cell, and fluorescent microscopy data is an indispensable resource for learning representations of proteins. Despite major developments in molecular representation…

Quantitative Methods · Quantitative Biology 2022-05-25 Anastasia Razdaibiedina , Alexander Brechalov

While modern biotechnologies allow synthesizing new proteins and function measurements at scale, efficiently exploring a protein sequence space and engineering it remains a daunting task due to the vast sequence space of any given protein.…

Biomolecules · Quantitative Biology 2024-01-15 Jiahao Qiu , Hui Yuan , Jinghong Zhang , Wentao Chen , Huazheng Wang , Mengdi Wang

Advanced automated AI techniques allow us to classify protein sequences and discern their biological families and functions. Conventional approaches for classifying these protein families often focus on extracting N-Gram features from the…

Quantitative Methods · Quantitative Biology 2024-10-24 Bahar Ali , Anwar Shah , Malik Niaz , Musadaq Mansoord , Sami Ullah , Muhammad Adnan

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

Metagenomics characterizes the taxonomic diversity of microbial communities by sequencing DNA directly from an environmental sample. One of the main challenges in metagenomics data analysis is the binning step, where each sequenced read is…

Quantitative Methods · Quantitative Biology 2015-05-27 Kévin Vervier , Pierre Mahé , Maud Tournoud , Jean-Baptiste Veyrieras , Jean-Philippe Vert

With the advent of high-throughput wet lab technologies the amount of protein interaction data available publicly has increased substantially, in turn spurring a plethora of computational methods for in silico knowledge discovery from this…

Molecular Networks · Quantitative Biology 2015-05-06 Sriganesh Srihari , Hon Wai Leong

The correct prediction of protein secondary structures is one of the key issues in predicting the correct protein folded shape, which is used for determining gene function. Existing methods make use of amino acids properties as indices to…

Quantitative Methods · Quantitative Biology 2017-05-01 Jian-Jun Shu , Kian-Yan Yong

Gradual pattern mining allows for extraction of attribute correlations through gradual rules such as: "the more X, the more Y". Such correlations are useful in identifying and isolating relationships among the attributes that may not be…

Databases · Computer Science 2021-06-29 Dickson Odhiambo Owuor

Classification is valuable and necessary in spectral analysis, especially for data-driven mining. Along with the rapid development of spectral surveys, a variety of classification techniques have been successfully applied to astronomical…

Instrumentation and Methods for Astrophysics · Physics 2022-12-20 Haifeng Yang , Lichan Zhou , Jianghui Cai , Chenhui Shi , Yuqing Yang , Xujun Zhao , Juncheng Duan , Xiaona Yin

Artificial intelligence is currently a dominant force in shaping various aspects of the world. Machine learning is a sub-field in artificial intelligence. Feature scaling is one of the data pre-processing techniques that improves the…

Machine Learning · Computer Science 2024-04-30 Niful Islam

Computational docking methods can provide structural models of protein-protein complexes, but protein backbone flexibility upon association often thwarts accurate predictions. In recent blind challenges, medium or high accuracy models were…

Biomolecules · Quantitative Biology 2020-12-29 Ameya Harmalkar , Jeffrey J. Gray