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Motivation: Read mapping is a computationally expensive process and a major bottleneck in genomics analyses. The performance of read mapping is mainly limited by the performance of three key computational steps: Index Querying, Seed…

Hardware Architecture · Computer Science 2023-10-02 Julien Eudine , Mohammed Alser , Gagandeep Singh , Can Alkan , Onur Mutlu

Summary: BGT is a compact format, a fast command line tool and a simple web application for efficient and convenient query of whole-genome genotypes and frequencies across tens to hundreds of thousands of samples. On real data, it encodes…

Genomics · Quantitative Biology 2017-08-07 Heng Li

Bayesian networks (BNs) are a widely used graphical model in machine learning for representing knowledge with uncertainty. The mainstream BN structure learning methods require performing a large number of conditional independence (CI)…

Machine Learning · Computer Science 2022-12-09 Jiantong Jiang , Zeyi Wen , Ajmal Mian

When building Burrows-Wheeler Transforms (BWTs) of truly huge datasets, prefix-free parsing (PFP) can use an unreasonable amount of memory. In this paper we show how if a dataset can be broken down into small datasets that are not very…

Data Structures and Algorithms · Computer Science 2025-06-09 Diego Diaz-Dominguez , Travis Gagie , Veronica Guerrini , Ben Langmead , Zsuzsanna Liptak , Giovanni Manzini , Francesco Masillo , Vikram Shivakumar

Existing approaches to train neural networks that use large images require to either crop or down-sample data during pre-processing, use small batch sizes, or split the model across devices mainly due to the prohibitively limited memory…

Image and Video Processing · Electrical Eng. & Systems 2020-03-12 Kushal Datta , Imtiaz Hossain , Sun Choi , Vikram Saletore , Kyle Ambert , William J. Godinez , Xian Zhang

Range minimum queries are frequently used in string processing and database applications including biological sequence analysis, document retrieval, and web search. Hence, various data structures have been proposed for improving their…

Databases · Computer Science 2026-04-03 Lara Kreis , Justus Henneberg , Valentin Henkys , Felix Schuhknecht , Bertil Schmidt

The Burrows-Wheeler transform (BWT) is a reversible transform that converts a string $w$ into another string $\mathsf{BWT}(w)$. The size of the run-length encoded BWT (RLBWT) can be interpreted as a measure of repetitiveness in the class of…

Discrete Mathematics · Computer Science 2024-11-19 Hideo Bannai , Tomohiro I , Yuto Nakashima

In this article we extend the elegant in-place Burrows-Wheeler transform (BWT) algorithm proposed by Crochemore et al. (Crochemore et al., 2015). Our extension is twofold: we first show how to compute simultaneously the longest common…

Data Structures and Algorithms · Computer Science 2018-06-08 Felipe A. Louza , Travis Gagie , Guilherme P. Telles

Hash tables are ubiquitous. Properties such as an amortized constant time complexity for insertion and querying as well as a compact memory layout make them versatile associative data structures with manifold applications. The rapidly…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-11-13 Daniel Jünger , Robin Kobus , André Müller , Christian Hundt , Kai Xu , Weiguo Liu , Bertil Schmidt

GPUs are uniquely suited to accelerate (SQL) analytics workloads thanks to their massive compute parallelism and High Bandwidth Memory (HBM) -- when datasets fit in the GPU HBM, performance is unparalleled. Unfortunately, GPU HBMs remain…

A concurrent binary tree (CBT) is a GPU-friendly data-structure suitable for the generation of bisection based terrain tessellations, i.e., adaptive triangulations over square domains. In this paper, we expand the benefits of this…

Graphics · Computer Science 2024-07-03 Anis Benyoub , Jonathan Dupuy

Our formulation reveals that the reduction across the sequence axis can be efficiently computed in parallel through a tree reduction. Our algorithm, called Tree Attention, for parallelizing exact attention computation across multiple GPUs…

Machine Learning · Computer Science 2025-02-11 Vasudev Shyam , Jonathan Pilault , Emily Shepperd , Quentin Anthony , Beren Millidge

The Burrows-Wheeler Transform (BWT) is an invertible text transformation that permutes symbols of a text according to the lexicographical order of its suffixes. BWT is the main component of popular lossless compression programs (such as…

Data Structures and Algorithms · Computer Science 2021-04-13 Dominik Kempa , Tomasz Kociumaka

Motivation: Single Molecule Real-Time (SMRT) sequencing technology and Oxford Nanopore technologies (ONT) produce reads over 10kbp in length, which have enabled high-quality genome assembly at an affordable cost. However, at present, long…

Genomics · Quantitative Biology 2017-08-07 Heng Li

The click-through rate (CTR) prediction task is to predict whether a user will click on the recommended item. As mind-boggling amounts of data are produced online daily, accelerating CTR prediction model training is critical to ensuring an…

DNA sequencing, especially of microbial genomes and metagenomes, has been at the core of recent research advances in large-scale comparative genomics. The data deluge has resulted in exponential growth in genomic datasets over the past…

Continuous Wavelet Transform (CWT) is frequently used for waveform analysis. For example, in the field of neuroscience research, CWT is performed to analyze electroencephalograms (EEG) and calculate the index of brain activity. Recent…

Quantitative Methods · Quantitative Biology 2025-06-10 Shoichiro Nakanishi

Modern genomic analyses increasingly rely on pangenomes, that is, representations of the genome of entire populations. The simplest representation of a pangenome is a set of individual genome sequences. Compared to e.g. sequence graphs,…

Genomics · Quantitative Biology 2025-11-25 Jannik Olbrich , Enno Ohlebusch

Computational Pangenomics is an emerging field that studies genetic variation using a graph structure encompassing multiple genomes. Visualizing pangenome graphs is vital for understanding genome diversity. Yet, handling large graphs can be…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-29 Jiajie Li , Jan-Niklas Schmelzle , Yixiao Du , Simon Heumos , Andrea Guarracino , Giulia Guidi , Pjotr Prins , Erik Garrison , Zhiru Zhang

In this work we propose an accelerated stochastic learning system for very large-scale applications. Acceleration is achieved by mapping the training algorithm onto massively parallel processors: we demonstrate a parallel, asynchronous GPU…

Machine Learning · Computer Science 2017-02-24 Thomas Parnell , Celestine Dünner , Kubilay Atasu , Manolis Sifalakis , Haris Pozidis
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