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Lipid membranes in a physiological context cannot be understood without taking into account their mobile environment. Here, we report on a high energy-resolution neutron backscattering study to investigate slow motions on nanosecond time…

Biological Physics · Physics 2007-05-23 Maikel C. Rheinstädter , Tilo Seydel , Tim Salditt

Using molecular dynamics simulations we study the static and dynamic properties of spherical nanoparticles (NPs) embedded in a disordered and polydisperse polymer network. Purely repulsive (RNP) as well as weakly attractive (ANP) polymer-NP…

Soft Condensed Matter · Physics 2023-02-15 Valerio Sorichetti , Virginie Hugouvieux , Walter Kob

In cell membranes, proteins and lipids diffuse in a highly crowded and heterogeneous landscape, where aggregates and dense domains of proteins or lipids obstruct the path of diffusing molecules. In general, hindered motion gives rise to…

Soft Condensed Matter · Physics 2010-06-16 Margaret R. Horton , Felix Höfling , Joachim O. Rädler , Thomas Franosch

The excimer formation dynamics of pyrene-labeled molecules in lipid bilayers depends on molecular motion over distances of the order of 1-2 nm. From the concentration dependence of the excimer photoemission curve, it is possible to derive a…

Soft Condensed Matter · Physics 2022-04-12 Pierre Ayoub , Fabrice Thalmann

The diffusion motions of individual polymer aggregates in disordered porous media were visualized using the single particle tracking (SPT) method because the motions inside porous media play important roles in various fields of science and…

Soft Condensed Matter · Physics 2024-10-24 Yusaku Abe , Naoki Tomioka , Yu Matsuda

Diffusion of tracer dye molecules in water confined to nanoscale is an important subject with a direct bearing on many technological applications. It is not yet clear however, if the dynamics of water in hydrophilic as well as hydrophobic…

Soft Condensed Matter · Physics 2022-01-19 Shivprasad Patil , V. J. Ajith

Nanoscale topographic features of solid surfaces can induce complex metastable behavior in colloidal and multiphase systems. Recent studies on single microparticle adsorption at liquid interfaces have reported a crossover from fast…

Soft Condensed Matter · Physics 2018-04-27 Bibin M. Jose , Dhiraj Nandyala , Thomas Cubaud , Carlos E. Colosqui

We report a high energy-resolution neutron backscattering study to investigate slow motions on nanosecond time scales in highly oriented solid supported phospholipid bilayers of the model system DMPC -d54 (deuterated…

Soft Condensed Matter · Physics 2007-05-23 Maikel C. Rheinstädter , Tilo Seydel , Tim Salditt

We use a long, all-atom molecular dynamics (MD) simulation combined with theoretical modeling to investigate the dynamics of selected lipid atoms and lipid molecules in a hydrated diyristoyl-phosphatidylcholine (DMPC) lipid bilayer. From…

Biological Physics · Physics 2009-11-13 Elijah Flenner , Jhuma Das , Maikel C. Rheinstadter , Ioan Kosztin

Transport of solid particles in blood flow exhibits qualitative differences in the transport mechanism when the particle varies from nanoscale to microscale size comparable to the red blood cell (RBC). The effect of microscale particle…

Soft Condensed Matter · Physics 2019-10-15 Zixiang Liu , Jonathan R. Clausen , Rekha R. Rao , Cyrus K. Aidun

We present a method to probe molecular and nanoparticle diffusion within thin, solvated polymer coatings. The device exploits the confinement with well-defined geometry that forms at the interface between a planar and a hemi-spherical…

We observe that gold atoms deposited by physical vapor deposition onto few layer graphenes condense upon annealing to form nanoparticles with an average diameter that is determined by the graphene film thickness. The data are well described…

Mesoscale and Nanoscale Physics · Physics 2015-05-18 Zhengtang Luo , Luke A. Somers , Yaping Dan , Thomas Ly , Nicholas J. Kybert , E. J. Mele , A. T. Charlie Johnson

Diffusion at solid-liquid interfaces is crucial in many technological and biophysical processes. Although its behavior seems deceivingly simple, recent studies showing passive superdiffusive transport suggest diffusion on surfaces may hide…

Statistical Mechanics · Physics 2016-05-25 Diego Krapf , Grace Campagnola , Kanti Nepal , Olve B. Peersen

Understanding the dynamics of molecules adsorbed to surfaces or confined to small volumes is a matter of increasing scientific and technological importance. Here, we demonstrate a pulse protocol using individual paramagnetic nitrogen…

Mesoscale and Nanoscale Physics · Physics 2015-10-28 T. Staudacher , N. Raatz , S. Pezzagna , J. Meijer , F. Reinhard , C. A. Meriles , J. Wrachtrup

Multicomponent lipid mixtures exhibit complex phase behavior, including coexistence of nanoscopic fluid phases in ternary mixtures mimicking the composition of the outer leaflet of mammalian plasma membrane. The physical mechanisms…

Soft Condensed Matter · Physics 2011-06-01 Frederick A. Heberle , Gerald W. Feigenson

We have used a gold nanohole array to trap single polystyrene nanoparticles, with a mean diameter of 30 nm, into separated hot spots located at connecting nanoslot regions. A high trap stiffness of approximately 0.85 fN/(nmmW) at a low…

Optics · Physics 2019-08-16 Xue Han , Viet Giang Truong , Sile Nic Chormaic

We have investigated the optically measurable properties of single evaporating microdroplets of suspensions containing up-converting luminescent nanoparticles (Gd2O3:Er3+), levitated in a linear electrodynamic trap. These microdroplets…

We study lipid translocation ("flip-flop") between the leaflets of a planar lipid bilayer with transition path sampling (TPS). Rare flip-flops compete with biological machineries that actively establish asymmetric lipid compositions.…

Soft Condensed Matter · Physics 2025-02-18 Matthias Post , Gerhard Hummer

Nanoindentation is a convenient method to investigate the mechanical properties of materials on small scales by utilizing low loads and small indentation depths. However, the effect of grain boundaries (GB) on the nanoindentation response…

Materials Science · Physics 2019-03-27 Songjiang Lu , Bo Zhang , Xiangyu Li , Junwen Zhao , Michael Zaiser , Haidong Fan , Xu Zhang

Precise radiation delivery is critical for effective radiotherapy, and gold nanoparticles (AuNPs) have emerged as promising tools to enhance local dose deposition while sparing the surrounding healthy tissue. In this study, the PENELOPE…