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White blood cells, also known as leukocytes are group of heterogeneously nucleated cells which act as salient immune system cells. These are originated in the bone marrow and are found in blood, plasma, and lymph tissues. Leukocytes kill…

Image and Video Processing · Electrical Eng. & Systems 2023-12-01 Shrijeet Biswas , Amartya Bhattacharya

High-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers…

Medical Physics · Physics 2020-07-31 Viacheslav Mazlin , Kristina Irsch , Michel Paques , Mathias Fink , Albert Claude Boccara

An integrated microscope that combines different optical techniques for simultaneous imaging is demonstrated. The microscope enables spectral-domain optical coherence microscopy based on optical backscatter, and multi-photon microscopy for…

Optics · Physics 2009-11-11 C. Vinegoni , T. Ralston , W. Tan , W. Luo , D. L. Marks , S. A. Boppart

Optical images of transparent three-dimensional objects can be different from a replica of the object's cross section in the image plane due to refraction at the surface or in the body of the object. Simulations of the object's image are…

Reflection phase imaging provides label-free, high-resolution characterization of biological samples, typically using interferometric-based techniques. Here, we investigate reflection phase microscopy from intensity-only measurements under…

Quantitative Methods · Quantitative Biology 2019-12-18 Alex Matlock , Anne Sentenac , Patrick C. Chaumet , Ji Yi , Lei Tian

Imaging through a single optical fiber offers attractive possibilities in many applications such as microendoscopy or remote sensing. However, the direct transmission of an image through an optical fiber is difficult because spatial…

Optics · Physics 2015-05-29 Roman Barankov , Jerome Mertz

In this paper we propose a new approach to identify melanoma diseases by identifying the distribution of its main skin chromophores (melanin, oxyhemoglobin and deoxyhemoglobin) from multispectral dermatological images. Based on Blind Source…

Medical Physics · Physics 2023-09-22 Mustapha Zokay , Hicham Saylani

Intracellular lasers are emerging as powerful biosensors for multiplexed tracking and precision sensing of cells and their microenvironment. This sensing capacity is enabled by quantifying their narrow-linewidth emission spectra, which is…

The spread of microbial infections is governed by the self-organization of bacteria on surfaces. Limitations of live imaging techniques make collective behaviors in clinically relevant systems challenging to quantify. Here, novel…

Biological Physics · Physics 2024-07-19 Vincent Hickl , Abid Khan , René M. Rossi , Bruno F. B. Silva , Katharina Maniura-Weber

Recently, novel imaging techniques based on the 'memory-effect' speckle-correlations have enabled diffraction-limited imaging through scattering layers and around corners. These techniques, however, are currently limited to imaging only…

Optics · Physics 2018-11-14 Ofer Salhov , Gil Weinberg , Ori Katz

This is the first article in a series of three dealing with the exploitation of speckle for imaging purposes. Speckle is the complex interference wave-field produced by a random distribution of un-resolved scatterers. In this paper, we show…

Applied Physics · Physics 2026-02-06 Elsa Giraudat , Flavien Bureau , William Lambert , Mathias Fink , Alexandre Aubry

We have carried out theoretical research on ultra-high resolution spectroscopy of atoms (or molecules) in the suggested cell with a series of plane-parallel thin gas layers between spatially separated gas regions of this cell for optical…

Atomic Physics · Physics 2015-06-11 Azad Ch. Izmailov

We report on the 3-dimensional imaging of biological cells including living neurons by a recently developed fibered interferometric Scanning Optical Microscope. The topography and surface structure of mouse fibroblasts and hippocampal…

This paper provides a mathematical analysis of ultrafast ultrasound imaging. This newly emerging modality for biomedical imaging uses plane waves instead of focused waves in order to achieve very high frame rates. We derive the point spread…

Numerical Analysis · Mathematics 2017-01-09 Giovanni S. Alberti , Habib Ammari , Francisco Romero , Timothée Wintz

Non-invasive detection of objects embedded inside an optically scattering medium is essential for numerous applications in engineering and sciences. However, in most applications light at visible or near-infrared wavebands is scattered by…

Optical imaging through scattering media is a long-standing challenge. Although many approaches have been developed to focus light or image objects through scattering media, they are either invasive, restricted to stationary or…

Optics · Physics 2022-10-11 Xingchen Zhao , Xiaoyu Nie , Zhenhuan Yi , Tao Peng , Marlan O. Scully

We demonstrate that a deep neural network can significantly improve optical microscopy, enhancing its spatial resolution over a large field-of-view and depth-of-field. After its training, the only input to this network is an image acquired…

Machine Learning · Computer Science 2017-11-21 Yair Rivenson , Zoltan Gorocs , Harun Gunaydin , Yibo Zhang , Hongda Wang , Aydogan Ozcan

The multiple scattering of coherent light is a problem of both fundamental and applied importance. In optics, phase conjugation allows spatial focussing and imaging through a multiply scattering medium; however, temporal control is…

Capturing biological specimens at large scales with sub-micron resolution is crucial for biomedical research, but conventional cameras often can't handle the pixel requirements. While most microscopes use motorized stages to move samples…

Optics · Physics 2025-03-28 Charlie Kersuzan , Aymerick Bazin , Amaury Badon

Imaging with optical resolution through highly scattering media is a long sought-after goal with important applications in deep tissue imaging. Although being the focus of numerous works, this goal was considered impractical until recently.…

Optics · Physics 2012-02-10 Ori Katz , Eran Small , Yaron Silberberg
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