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We model multi-dimensional two-phase flows of incompressible fluids in porous media using generalized Forchheimer equations and the capillary pressure. Firstly, we find a family of steady state solutions whose saturation and pressure are…
This paper is concerned with the asymptotic stability of planar stationary solution to an initial-boundary value problem for a two-dimensional hyperbolic-elliptic coupled system of the radiating gas in half space. We show that the solution…
We investigate the evolution of tumor growth relying on a nonlinear model of partial differential equations which incorporates mechanical laws for tissue compression combined with rules for nutrients availability and drug application.…
We investigate the tumor boundary instability induced by nutrient consumption and supply based on a Hele-Shaw model derived from taking the incompressible limit of a cell density model. We analyze the boundary stability/instability in two…
We consider a moving boundary mathematical model of biological invasion. The model describes the spatiotemporal evolution of two adjacent populations: each population undergoes linear diffusion and logistic growth, and the boundary between…
In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field…
We present a robust computational framework for Hele-Shaw tumor growth with necrotic cores, a problem identified as the incompressible limit of the Porous Media Equation. Simulating this system presents a fundamental challenge: while the…
We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…
In this manuscript, we study a nonlinear model of tumor growth, described by a coupled hyperbolic-elliptic system of partial differential equations. In this model, the compressible flow of tumor cells is modeled by a transport equation for…
Initiation and development of a malignant tumor is a complex phenomenon that has critical stages determining its long time behavior. This phenomenon is mathematically described by means of various models: from simple heuristic models to…
In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…
In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalized and relaxed version…
Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical…
Spiral waves are a ubiquitous feature of the nonequilibrium dynamics of a great variety of excitable systems. In the limit of a large separation in timescale between fast excitation and slow recovery, one can reduce the spiral problem to…
The speed and the versatility of today's computers open up new opportunities to simulate complex biological systems. Here we review a computational approach recently proposed by us to model large tumor cell populations and spheroids, and we…
We present a method for solving the two-dimensional linearized collisionless Boltzmann equation using Fourier expansion along the orbits. It resembles very much solutions present in the literature, but it differs by the fact that everything…
We study the spatial evolutionary dynamics of solid tumors as they obtain additional driver mutations. We start with a cancer clone that expands uniformly in three dimensions giving rise to a spherical shape. We assume that cell division…
Background: Radiotherapy outcomes are usually predicted using the Linear Quadratic model. However, this model does not integrate complex features of tumor growth, in particular cell cycle regulation. Methods: In this paper, we propose a…
We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…
We study the planar front solution for a class of reaction diffusion equations in multidimensional space in the case when the essential spectrum of the linearization in the direction of the front touches the imaginary axis. At the linear…