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Multiple Instance Learning (MIL) has emerged as a promising paradigm for Whole Slide Image (WSI) diagnosis, offering effective learning with limited annotations. However, existing MIL frameworks overlook diagnostic priorities and fail to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Sungrae Hong , Jiwon Jeong , Jisu Shin , Donghee Han , Sol Lee , Kyungeun Kim , Mun Yong Yi

Multi-typed objects Multi-view Multi-instance Multi-label Learning (M4L) deals with interconnected multi-typed objects (or bags) that are made of diverse instances, represented with heterogeneous feature views and annotated with a set of…

Machine Learning · Computer Science 2020-10-07 Yuanlin Yang , Guoxian Yu , Jun Wang , Carlotta Domeniconi , Xiangliang Zhang

Multiple instance learning (MIL) has been increasingly used in the classification of histopathology whole slide images (WSIs). However, MIL approaches for this specific classification problem still face unique challenges, particularly those…

Computer Vision and Pattern Recognition · Computer Science 2022-03-24 Hongrun Zhang , Yanda Meng , Yitian Zhao , Yihong Qiao , Xiaoyun Yang , Sarah E. Coupland , Yalin Zheng

Multiple instance learning (MIL) is a robust paradigm for whole-slide pathological image (WSI) analysis, processing gigapixel-resolution images with slide-level labels. As pioneering efforts, attention-based MIL (ABMIL) and its variants are…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Linghan Cai , Shenjin Huang , Ye Zhang , Jinpeng Lu , Yongbing Zhang

Multiple instance learning (MIL) is an effective and widely used approach for weakly supervised machine learning. In histopathology, MIL models have achieved remarkable success in tasks like tumor detection, biomarker prediction, and…

Fuzzy logic is a powerful tool to model knowledge uncertainty, measurements imprecision, and vagueness. However, there is another type of vagueness that arises when data have multiple forms of expression that fuzzy logic does not address…

Neural and Evolutionary Computing · Computer Science 2016-10-18 Amine Ben Khalifa , Hichem Frigui

Multiple instance data are sets or multi-sets of unordered elements. Using metrics or distances for sets, we propose an approach to several multiple instance learning tasks, such as clustering (unsupervised learning), classification…

Machine Learning · Computer Science 2017-03-28 Quang N. Tran , Ba-Ngu Vo , Dinh Phung , Ba-Tuong Vo , Thuong Nguyen

We address the challenging problem of whole slide image (WSI) classification. WSIs have very high resolutions and usually lack localized annotations. WSI classification can be cast as a multiple instance learning (MIL) problem when only…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Bin Li , Yin Li , Kevin W. Eliceiri

Multiple Instance Learning (MIL) is increasingly being used as a support tool within clinical settings for pathological diagnosis decisions, achieving high performance and removing the annotation burden. However, existing approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Sungrae Hong , Kyungeun Kim , Juhyeon Kim , Sol Lee , Jisu Shin , Chanjae Song , Mun Yong Yi

We explore multiple instance verification, a problem setting in which a query instance is verified against a bag of target instances with heterogeneous, unknown relevancy. We show that naive adaptations of attention-based multiple instance…

Machine Learning · Computer Science 2025-09-18 Xin Xu , Eibe Frank , Geoffrey Holmes

Of late, weakly supervised object detection is with great importance in object recognition. Based on deep learning, weakly supervised detectors have achieved many promising results. However, compared with fully supervised detection, it is…

Computer Vision and Pattern Recognition · Computer Science 2017-04-04 Peng Tang , Xinggang Wang , Xiang Bai , Wenyu Liu

Labeling data for classification requires significant human effort. To reduce labeling cost, instead of labeling every instance, a group of instances (bag) is labeled by a single bag label. Computer algorithms are then used to infer the…

Machine Learning · Statistics 2014-11-18 Anh T. Pham , Raviv Raich , Xiaoli Z. Fern

Multiple instance learning (MIL) stands as a powerful approach in weakly supervised learning, regularly employed in histological whole slide image (WSI) classification for detecting tumorous lesions. However, existing mainstream MIL methods…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Wenhui Zhu , Xiwen Chen , Peijie Qiu , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue images. However, MIL often struggles with small, weakly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Daniel Shao , Richard J. Chen , Andrew H. Song , Joel Runevic , Ming Y. Lu , Tong Ding , Faisal Mahmood

Multiple instance learning (MIL) has been extensively applied to whole slide histopathology image (WSI) analysis. The existing aggregation strategy in MIL, which primarily relies on the first-order distance (e.g., mean difference) between…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Yihang Chen , Tsai Hor Chan , Guosheng Yin , Yuming Jiang , Lequan Yu

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

We propose a new problem formulation which is similar to, but more informative than, the binary multiple-instance learning problem. In this setting, we are given groups of instances (described by feature vectors) along with estimates of the…

Machine Learning · Computer Science 2012-07-09 Hendrik Kuck , Nando de Freitas

Weakly supervised multiple instance learning (MIL) is a challenging task given that only bag-level labels are provided, while each bag typically contains multiple instances. This topic has been extensively studied in histopathological image…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Bodong Zhang , Hamid Manoochehri , Xiwen Li , Beatrice S. Knudsen , Tolga Tasdizen

Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is a common solution for working with high resolution…

Deep learning-based classification of rare anemia disorders is challenged by the lack of training data and instance-level annotations. Multiple Instance Learning (MIL) has shown to be an effective solution, yet it suffers from low accuracy…

Machine Learning · Computer Science 2022-07-06 Salome Kazeminia , Ario Sadafi , Asya Makhro , Anna Bogdanova , Shadi Albarqouni , Carsten Marr
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